1107/10 | Tocris Bioscience 1107/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1107/10

catalog :

1107/10

quantity :

10 mg (also 50 mg)

price :

285 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Langner E, Lemieszek M, Kwiecien J, Rajtar G, Rzeski W, Turski W. Kynurenic Acid Induces Impairment of Oligodendrocyte Viability: On the Role of Glutamatergic Mechanisms. Neurochem Res. 2017;42:838-845 pubmed publisher
Song Q, Liu M, Zhuo M. Minocycline does not affect long-term potentiation in the anterior cingulate cortex of normal adult mice. Mol Pain. 2015;11:25 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Randall F, Whittington M, Cunningham M. Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro. Eur J Neurosci. 2011;33:914-22 pubmed publisher
Talpalar A, Kiehn O. Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG. Front Neural Circuits. 2010;4: pubmed publisher
Dargan S, Clarke V, Alushin G, Sherwood J, NisticÃ² R, Bortolotto Z, et al. ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. Neuropharmacology. 2009;56:121-30 pubmed publisher
Xu H, Wu L, Zhao M, Toyoda H, Vadakkan K, Jia Y, et al. Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Mol Pain. 2006;2:29 pubmed
Liu Q, Xu Q, Arcuino G, Kang J, Nedergaard M. Astrocyte-mediated activation of neuronal kainate receptors. Proc Natl Acad Sci U S A. 2004;101:3172-7 pubmed

product information

master code :

1107

SKU :

1107/10

product name :

ATPA

unit size :

10 mg (also 50 mg)

description :

Potent and selective GluK1 kainate agonist

target :

Kainate Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

228.25

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ATPA is a selective and potent GluK1 (formerly GluR5) kainate receptor agonist (Ki = 4.3 nM), inactive at GluK6 (formerly GluR6) (Ki 1 mM) and only weakly active at AMPA receptors (GluA1-4) and the kainate receptors GluK5 (formerly KA-2) and GluK3 (formerly GluR7) (Ki values of 6 - 14 u M). . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

top caption :

Potent and selective GluK1 kainate agonist

extended description :

Potent and selective GluK1 kainate agonist

chemical name text :

(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid

formula :

C10H16N2O4

formula text :

C10H16N2O4

cas num :

140158-50-5

USD :

285 USD

product details :

Potent and selective GluK1 kainate agonist

storage :

Desiccate at +4░C

more info or order :

Tocris Bioscience product webpage