product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
2-Cl-IB-MECA
catalog :
1104
quantity :
10 mg (also 50 mg)
price :
388 USD
more info or order :
citations: 13
Reference |
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Iannone R, Miele L, Maiolino P, Pinto A, Morello S. Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model. Am J Cancer Res. 2014;4:172-81 pubmed
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Morello S, Sorrentino R, Montinaro A, Luciano A, Maiolino P, Ngkelo A, et al. NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model. Neoplasia. 2011;13:365-73 pubmed
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Germack R, Dickenson J. Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes. Br J Pharmacol. 2004;141:329-39 pubmed
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De Man J, Seerden T, De Winter B, Van Marck E, Herman A, Pelckmans P. Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation. Br J Pharmacol. 2003;139:172-84 pubmed
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product information
brand :
Tocris
master code :
1104
SKU :
1104/10
product name :
2-Cl-IB-MECA
description :
Highly selective A3 agonist
target :
Adenosine A3 Receptor Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
544.74
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
High affinity and extremely selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. Exhibits high selectivity over the Na+-independent adenosine transporter.
catalog number base :
1104
product keywords :
selective A3 agonists Receptors adenosines 2ClIBMECA Adenosine A3 Receptors 1104,
extended description :
Highly selective A3 agonist
chemical name text :
1-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl- -D-ribofuranuronamide
formula :
C 18 H 18 ClIN 6 O 4
formula text :
C18H18ClIN6O4
cas num :
163042-96-4
2020 USD :
373
2021 USD :
388 USD
storage :
Desiccate at +4°C
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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