1104/10 | Tocris Bioscience 1104/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1104/10

catalog :

1104/10

quantity :

10 mg (also 50 mg)

price :

502 USD

more info or order :

Tocris Bioscience product webpage

citations: 16

Reference
Nakashima K, Iwao K, Inoue T, Haga A, Tsutsumi T, Mochita M, et al. Stimulation of the adenosine A3 receptor, not the A1 or A2 receptors, promote neurite outgrowth of retinal ganglion cells. Exp Eye Res. 2018;170:160-168 pubmed publisher
Di Angelantonio S, Bertollini C, Piccinin S, Rosito M, Trettel F, Pagani F, et al. Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R. Front Cell Neurosci. 2015;9:409 pubmed publisher
Ren T, Tian T, Feng X, Ye S, Wang H, Wu W, et al. An adenosine A3 receptor agonist inhibits DSS-induced colitis in mice through modulation of the NF-ÎºB signaling pathway. Sci Rep. 2015;5:9047 pubmed publisher
Iannone R, Miele L, Maiolino P, Pinto A, Morello S. Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model. Am J Cancer Res. 2014;4:172-81 pubmed
Subramanian M, Kini R, Madasu M, Ohta A, Nowak M, Exley M, et al. Extracellular adenosine controls NKT-cell-dependent hepatitis induction. Eur J Immunol. 2014;44:1119-29 pubmed publisher
Corriden R, Self T, Akong Moore K, Nizet V, Kellam B, Briddon S, et al. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO Rep. 2013;14:726-32 pubmed publisher
Vincenzi F, Targa M, Corciulo C, Gessi S, Merighi S, Setti S, et al. Pulsed electromagnetic fields increased the anti-inflammatory effect of A?A and A? adenosine receptors in human T/C-28a2 chondrocytes and hFOB 1.19 osteoblasts. PLoS ONE. 2013;8:e65561 pubmed publisher
Montinaro A, Forte G, Sorrentino R, Luciano A, Palma G, Arra C, et al. Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice. PLoS ONE. 2012;7:e45401 pubmed publisher
Kan Y, Okabayashi T, Yokota S, Yamamoto S, Fujii N, Yamashita T. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012;86:10338-46 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Rosito M, Deflorio C, Limatola C, Trettel F. CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to protect neurons from excitotoxic cell death in the CNS. J Neurosci. 2012;32:3154-63 pubmed publisher
Jinka T, Tøien Ø, Drew K. Season primes the brain in an arctic hibernator to facilitate entrance into torpor mediated by adenosine A(1) receptors. J Neurosci. 2011;31:10752-8 pubmed publisher
Morello S, Sorrentino R, Montinaro A, Luciano A, Maiolino P, Ngkelo A, et al. NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model. Neoplasia. 2011;13:365-73 pubmed
Bhanu N, Lee Y, Oneal P, Gantt N, Aerbajinai W, Noel P, et al. Inhibition of erythroblast growth and fetal hemoglobin production by ribofuranose-substituted adenosine derivatives. Biochim Biophys Acta. 2008;1782:504-10 pubmed publisher
Germack R, Dickenson J. Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes. Br J Pharmacol. 2004;141:329-39 pubmed
De Man J, Seerden T, De Winter B, Van Marck E, Herman A, Pelckmans P. Alteration of the purinergic modulation of enteric neurotransmission in the mouse ileum during chronic intestinal inflammation. Br J Pharmacol. 2003;139:172-84 pubmed

product information

master code :

1104

SKU :

1104/10

product name :

2-Cl-IB-MECA

unit size :

10 mg (also 50 mg)

description :

Highly selective A3 agonist

target :

Adenosine A3 Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

544.74

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

2-Cl-IB-MECA is a high affinity and extremely selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively. Exhibits high selectivity over the Na+-independent adenosine transporter.

top caption :

Highly selective A3 agonist

extended description :

Highly selective A3 agonist

chemical name text :

1-[2-Chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl- -D-ribofuranuronamide

formula :

C18H18ClIN6O4

formula text :

C18H18ClIN6O4

cas num :

163042-96-4

USD :

502 USD

product details :

Highly selective A3 agonist

storage :

Desiccate at +4░C

more info or order :

Tocris Bioscience product webpage