product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Cyclosporin A
catalog :
1101
quantity :
100 mg
price :
128 USD
more info or order :
citations: 24
Reference
Puri R, Cheng X, Lin M, Huang N, Sheng Z. Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts. Nat Commun. 2019;10:3645 pubmed publisher
Bhosale G, Duchen M. Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening. Curr Protoc Pharmacol. 2019;85:e59 pubmed publisher
Battefeld A, Popovic M, de Vries S, Kole M. High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling. Cell Rep. 2019;26:182-191.e5 pubmed publisher
Panja D, Vedeler C, Schubert M. Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity. Neuropathol Appl Neurobiol. 2019;45:141-156 pubmed publisher
Perez M, Ponce D, Aranguiz A, Behrens M, Quintanilla R. Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease. Redox Biol. 2018;19:290-300 pubmed publisher
Burdyga A, Surdo N, Monterisi S, Di Benedetto G, Grisan F, Penna E, et al. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane. Proc Natl Acad Sci U S A. 2018;115:E6497-E6506 pubmed publisher
Agarwal A, Wu P, Hughes E, Fukaya M, Tischfield M, Langseth A, et al. Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron. 2017;93:587-605.e7 pubmed publisher
O Donnell J, Jackson J, Robinson M. Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. J Neurosci. 2016;36:7109-27 pubmed publisher
Palmqvist N, Siller M, Klint C, Sjödin A. A human and animal model-based approach to investigating the anti-inflammatory profile and potential of the 5-HT2B receptor antagonist AM1030. J Inflamm (Lond). 2016;13:20 pubmed publisher
Cui Y, Prokin I, Xu H, Delord B, Genet S, Venance L, et al. Endocannabinoid dynamics gate spike-timing dependent depression and potentiation. elife. 2016;5:e13185 pubmed publisher
Miyamoto T, Kim D, Knox J, Johnson E, Mucke L. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem. 2016;291:1719-34 pubmed publisher
Draganov D, Gopalakrishna Pillai S, Chen Y, Zuckerman N, Moeller S, Wang C, et al. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. Sci Rep. 2015;5:16222 pubmed publisher
Piccart E, Courtney N, Branch S, Ford C, Beckstead M. Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci. 2015;35:11144-52 pubmed publisher
Liu Y, Huang C, Chang C, Chou C, Lin S, Wang I, et al. Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment. Cardiorenal Med. 2015;5:79-88 pubmed publisher
Faralli J, Clark R, Filla M, Peters D. NFATc1 activity regulates the expression of myocilin induced by dexamethasone. Exp Eye Res. 2015;130:9-16 pubmed publisher
Yu Y, Yip K, Tam I, Sam S, Ng C, Zhang W, et al. Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. PLoS ONE. 2014;9:e112989 pubmed publisher
Gray E, Guglietta R, Khakh B, O Dell T. Inhibitory interactions between phosphorylation sites in the C terminus of ?-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits. J Biol Chem. 2014;289:14600-11 pubmed publisher
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Pont J, McArdle C, Lopez Bernal A. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol Endocrinol. 2012;26:1743-56 pubmed
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Belmeguenai A, Hansel C. A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation. J Neurosci. 2005;25:10768-72 pubmed
product information
brand :
Tocris
master code :
1101
SKU :
1101/100
product name :
Cyclosporin A
description :
Calcineurin inhibitor
target :
Protein Ser/Thr Phosphatase Inhibitors
category :
Small Molecules
unit size :
100 mg
purity :
99%
observed molecular weight :
1202.63
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Immunosuppressant; simultaneously binds calcineurin and cyclophilin and inhibits phosphatase activity of calcineurin (IC50 = 5 nM). Additionally inhibits formation and opening of the mitochondrial permeability transition pore (MPTP). Also inhibits coronavirus replication in vitro . Enhances lentirival transduction of bone marrow-derived CD34+ cells and is additive with Prostaglandin E2 (Cat. No. 2296).
catalog number base :
1101
product keywords :
Calcineurin inhibitors Protein Ser/Thr Phosphatases CyclosporinA immunosuppressant CsA inhibits mPTP mitochondrial permeability transition pore antibiotics coronaviruses SARS-CoV severe acute respiratory syndrome COVID-19 MERS cyclophilin PPI peptidylprol Ciclosporin A Protein Ser/Thr Phosphatases Immunosuppressants MPTP NFAT Viral Transduction Enhancers COVID-19 Other Isomerases Coronavirus 1101,
extended description :
Calcineurin inhibitor
formula :
C 62 H 111 N 11 O 12
formula text :
C62H111N11O12
cas num :
59865-13-3
2020 USD :
121
2021 USD :
128 USD
alt names :
Ciclosporin A
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK