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company name :
Tocris Bioscience
product type :
chemical
product name :
1099/10
catalog :
1099/10
quantity :
10 mg (also 50 mg)
price :
212 USD
more info or order :
citations: 99
Reference
Hendriks D, Artegiani B, Hu H, Chuva de Sousa Lopes S, Clevers H. Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout in organoid cultures from human liver. Nat Protoc. 2021;16:182-217 pubmed publisher
Liu J, Li P, Wang L, Li M, Ge Z, Noordam L, et al. Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance. Cell Mol Gastroenterol Hepatol. 2021;11:407-431 pubmed publisher
Driehuis E, Kretzschmar K, Clevers H. Establishment of patient-derived cancer organoids for drug-screening applications. Nat Protoc. 2020;15:3380-3409 pubmed publisher
Zhou R, Li S, Liu J, Wu H, Yao G, Sun Y, et al. Up-regulated FHL2 inhibits ovulation through interacting with androgen receptor and ERK1/2 in polycystic ovary syndrome. EBioMedicine. 2020;52:102635 pubmed publisher
Post Y, Puschhof J, Beumer J, Kerkkamp H, de Bakker M, Slagboom J, et al. Snake Venom Gland Organoids. Cell. 2020;180:233-247.e21 pubmed publisher
French A, Tesmer A, Tantama M. Dual-Mode FRET and BRET Sensors for Detecting cAMP Dynamics. ACS Omega. 2019;4:15504-15511 pubmed publisher
Franchini L, Stanic J, Ponzoni L, Mellone M, Carrano N, Musardo S, et al. Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition. iScience. 2019;19:927-939 pubmed publisher
Schnúr A, Premchandar A, Bagdany M, Lukacs G. Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia. Sci Rep. 2019;9:12706 pubmed publisher
Segal J, Kent D, Wesche D, Ng S, Serra M, Oulès B, et al. Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors. Nat Commun. 2019;10:3350 pubmed publisher
Garcia V, Rushton D, Tom C, Allen N, Kemp P, Svendsen C, et al. Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support. Front Neurosci. 2019;13:669 pubmed publisher
Chiu A, Wang J, Fiske M, Hubálková P, Barse L, Gray J, et al. NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content. Cell Rep. 2019;28:332-341.e5 pubmed publisher
Cordonier E, Liu T, Saito K, Chen S, Xu Y, Fukuda M. Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 Expression. J Endocr Soc. 2019;3:1246-1260 pubmed publisher
Jewell J, Fu V, Hong A, Yu F, Meng D, Melick C, et al. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. elife. 2019;8: pubmed publisher
Saito Y, Muramatsu T, Kanai Y, Ojima H, Sukeda A, Hiraoka N, et al. Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma. Cell Rep. 2019;27:1265-1276.e4 pubmed publisher
Sachs N, Papaspyropoulos A, Zomer van Ommen D, Heo I, Böttinger L, Klay D, et al. Long-term expanding human airway organoids for disease modeling. EMBO J. 2019;38: pubmed publisher
Delpiano L, Thomas J, Yates A, Rice S, Gray M, Saint Criq V. Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells. Front Pharmacol. 2018;9:1462 pubmed publisher
Ford M, Yeyati P, Mali G, Keighren M, Waddell S, Mjoseng H, et al. A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice. Dev Cell. 2018;47:509-523.e5 pubmed publisher
Costa L, Sardone L, Bonaccorso C, D Antoni S, Spatuzza M, Gulisano W, et al. Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome. Front Mol Neurosci. 2018;11:353 pubmed publisher
Mo K, Wu S, Gu X, Xiong M, Cai W, Atianjoh F, et al. MBD1 Contributes to the Genesis of Acute Pain and Neuropathic Pain by Epigenetic Silencing of Oprm1 and Kcna2 Genes in Primary Sensory Neurons. J Neurosci. 2018;38:9883-9899 pubmed publisher
Noh S, Gee H, Kim Y, Piao H, Kim J, Kang C, et al. Specific autophagy and ESCRT components participate in the unconventional secretion of CFTR. Autophagy. 2018;14:1761-1778 pubmed publisher
Patra K, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, et al. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol. 2018;20:811-822 pubmed publisher
Burdyga A, Surdo N, Monterisi S, Di Benedetto G, Grisan F, Penna E, et al. Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane. Proc Natl Acad Sci U S A. 2018;115:E6497-E6506 pubmed publisher
Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, et al. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018;9:1996 pubmed publisher
Tozzi A, Tantucci M, Marchi S, Mazzocchetti P, Morari M, Pinton P, et al. Dopamine D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson's disease. Cell Death Dis. 2018;9:204 pubmed publisher
Liu P, Chen M, Liu Y, Qi L, Ding S. CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. Cell Stem Cell. 2018;22:252-261.e4 pubmed publisher
Li X, Chen W, Li P, Wei J, Cheng Y, Liu P, et al. Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression. Theranostics. 2017;7:4671-4688 pubmed publisher
Burgueno J, Pujol M, Monroy X, Roche D, Varela M, Merlos M, et al. A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses. Sci Rep. 2017;7:15389 pubmed publisher
Gauster M, Maninger S, Siwetz M, Deutsch A, El Heliebi A, Kolb Lenz D, et al. Downregulation of p53 drives autophagy during human trophoblast differentiation. Cell Mol Life Sci. 2018;75:1839-1855 pubmed publisher
Bernhardt M, Novak D, Assenov Y, Orouji E, Knappe N, Weina K, et al. Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response. Stem Cell Reports. 2017;8:1379-1391 pubmed publisher
Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, et al. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017;169:243-257.e25 pubmed publisher
Al Taei S, Salimu J, Spary L, Clayton A, Lester J, Tabi Z. Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer. Oncoimmunology. 2017;6:e1268308 pubmed publisher
Demeautis C, Sipieter F, Roul J, Chapuis C, Padilla Parra S, Riquet F, et al. Multiplexing PKA and ERK1&2 kinases FRET biosensors in living cells using single excitation wavelength dual colour FLIM. Sci Rep. 2017;7:41026 pubmed publisher
Avanzato D, Genova T, Fiorio Pla A, Bernardini M, Bianco S, Bussolati B, et al. Activation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling. Sci Rep. 2016;6:32602 pubmed publisher
Havekes R, Park A, Tolentino R, Bruinenberg V, Tudor J, Lee Y, et al. Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory. J Neurosci. 2016;36:8936-46 pubmed publisher
Aguileta M, Rojas Rivera D, Goossens V, Estornes Y, Van Isterdael G, Vandenabeele P, et al. A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress. Cell Death Differ. 2016;23:1670-80 pubmed publisher
Chan E, Shetty M, Sajikumar S, Chen C, Soong T, Wong B. ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model. Sci Rep. 2016;6:26119 pubmed publisher
Pattabiraman D, Bierie B, Kober K, Thiru P, Krall J, Zill C, et al. Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability. Science. 2016;351:aad3680 pubmed publisher
Brzosko Z, Schultz W, Paulsen O. Retroactive modulation of spike timing-dependent plasticity by dopamine. elife. 2015;4: pubmed publisher
Polito M, Guiot E, Gangarossa G, Longueville S, Doulazmi M, Valjent E, et al. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). Eneuro. 2015;2: pubmed publisher
Siuda E, McCall J, Al Hasani R, Shin G, Il Park S, Schmidt M, et al. Optodynamic simulation of β-adrenergic receptor signalling. Nat Commun. 2015;6:8480 pubmed publisher
Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. J Biol Chem. 2015;290:25728-44 pubmed publisher
Muñoz Llancao P, Henríquez D, Wilson C, Bodaleo F, Boddeke E, Lezoualc h F, et al. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. J Neurosci. 2015;35:11315-29 pubmed publisher
Presley C, Abidi A, Suryawanshi S, Mustafa S, Meibohm B, Moore B. Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist. Pharmacol Res Perspect. 2015;3:e00159 pubmed publisher
Ben Simon Y, Rodenas Ruano A, Alviña K, Lam A, Stuenkel E, Castillo P, et al. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity. Cell Rep. 2015;12:396-404 pubmed publisher
Walker C, Eftekhari S, Bower R, Wilderman A, Insel P, Edvinsson L, et al. A second trigeminal CGRP receptor: function and expression of the AMY1 receptor. Ann Clin Transl Neurol. 2015;2:595-608 pubmed publisher
Sokolowska M, Chen L, Liu Y, Martinez Anton A, Qi H, Logun C, et al. Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages. J Immunol. 2015;194:5472-5487 pubmed publisher
Parnell E, Koschinski A, Zaccolo M, Cameron R, Baillie G, Baillie G, et al. Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells. Biochim Biophys Acta. 2015;1853:1749-58 pubmed publisher
Belgacem Y, Borodinsky L. Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. Proc Natl Acad Sci U S A. 2015;112:4140-5 pubmed publisher
Emery A, Liu X, Xu W, Eiden M, Eiden L. Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological Signaling through a Secretin Family Gs-Coupled G Protein-Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform. Mol Pharmacol. 2015;87:928-35 pubmed publisher
Moon C, Zhang W, Ren A, Arora K, Sinha C, Yarlagadda S, et al. Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea. J Biol Chem. 2015;290:11246-57 pubmed publisher
Li H, Liu T, Lim J, Gounko N, Hong W, Han W. Increased biogenesis of glucagon-containing secretory granules and glucagon secretion in BIG3-knockout mice. Mol Metab. 2015;4:246-52 pubmed publisher
Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, et al. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. Cell Death Dis. 2015;6:e1629 pubmed publisher
Ang Z, Er J, Ding J. The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes. Sci Rep. 2015;5:8134 pubmed publisher
Zhu G, Liu Y, Wang Y, Bi X, Baudry M. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways. J Neurosci. 2015;35:621-33 pubmed publisher
Devlin A, Burr K, Borooah S, Foster J, Cleary E, Geti I, et al. Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability. Nat Commun. 2015;6:5999 pubmed publisher
Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen M, et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 2015;160:299-312 pubmed publisher
Vandame P, Spriet C, Trinel D, Gelaude A, Caillau K, Bompard C, et al. The spatio-temporal dynamics of PKA activity profile during mitosis and its correlation to chromosome segregation. Cell Cycle. 2014;13:3232-40 pubmed publisher
Brust T, Hayes M, Roman D, Watts V. New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Biochem Pharmacol. 2015;93:85-91 pubmed publisher
Elliott A, Ustione A, Piston D. Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab. 2015;308:E130-43 pubmed publisher
Maury Y, Côme J, Piskorowski R, Salah Mohellibi N, Chevaleyre V, Peschanski M, et al. Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes. Nat Biotechnol. 2015;33:89-96 pubmed publisher
Broadbent S, Ramjeesingh M, Bear C, Argent B, Linsdell P, Gray M. The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor. Pflugers Arch. 2015;467:1783-94 pubmed publisher
Jansen S, Holman R, Hedemann I, Frankes E, Elzinga C, Timens W, et al. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. J Cell Mol Med. 2015;19:210-26 pubmed publisher
Shelton M, Metz J, Liu J, Carpenedo R, Demers S, Stanford W, et al. Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells. Stem Cell Reports. 2014;3:516-29 pubmed publisher
Muthusamy T, Mukherjee O, Menon R, Megha P, Panicker M. A method to identify and isolate pluripotent human stem cells and mouse epiblast stem cells using lipid body-associated retinyl ester fluorescence. Stem Cell Reports. 2014;3:169-84 pubmed publisher
Adelfinger L, Turecek R, Ivankova K, Jensen A, Moss S, Gassmann M, et al. GABAB receptor phosphorylation regulates KCTD12-induced K? current desensitization. Biochem Pharmacol. 2014;91:369-79 pubmed publisher
Barmada S, Serio A, Arjun A, Bilican B, Daub A, Ando D, et al. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nat Chem Biol. 2014;10:677-85 pubmed publisher
Chou J, Ramirez C, Ryba D, Koduri M, Effros R. Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells. PLoS ONE. 2014;9:e99432 pubmed publisher
Mitchell R, Szabo E, Shapovalova Z, Aslostovar L, Makondo K, Bhatia M. Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors. Stem Cells. 2014;32:2178-87 pubmed publisher
Cooke A, Oldfield S, Krasel C, Mundell S, Henderson G, Kelly E. Morphine-induced internalization of the L83I mutant of the rat ?-opioid receptor. Br J Pharmacol. 2015;172:593-605 pubmed publisher
Felizola S, Nakamura Y, Ono Y, Kitamura K, Kikuchi K, Onodera Y, et al. PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues. J Mol Endocrinol. 2014;52:159-67 pubmed publisher
Yang J, Polanowska Grabowska R, Smith J, Shields C, Saucerman J. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to ?-adrenergic signaling. J Mol Cell Cardiol. 2014;66:83-93 pubmed publisher
Jia J, Zhao J, Hu Z, Lindberg D, Li Z. Age-dependent regulation of synaptic connections by dopamine D2 receptors. Nat Neurosci. 2013;16:1627-36 pubmed publisher
Waheed A, Ludtmann M, Pakes N, Robery S, Kuspa A, Dinh C, et al. Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner. Br J Pharmacol. 2014;171:2659-70 pubmed publisher
Tao Y, Pan M, Liu S, Fang F, Lu R, Lu C, et al. cAMP level modulates scleral collagen remodeling, a critical step in the development of myopia. PLoS ONE. 2013;8:e71441 pubmed publisher
Ehrlich A, Furuyashiki T, Kitaoka S, Kakizuka A, Narumiya S. Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing G(??) subunits in human embryonic kidney 293T cells. Mol Pharmacol. 2013;84:476-86 pubmed publisher
Wiseman S, Shimizu Y, Palfrey C, Nairn A. Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCF?TRCP ubiquitin E3 ligase. J Biol Chem. 2013;288:17803-11 pubmed publisher
Pale T, Frisch E, McClellan A. Cyclic AMP stimulates neurite outgrowth of lamprey reticulospinal neurons without substantially altering their biophysical properties. Neuroscience. 2013;245:74-89 pubmed publisher
Sohn J, Harris L, Berglund E, Liu T, Vong L, Lowell B, et al. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell. 2013;152:612-9 pubmed publisher
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach Mansky R, Sacks D, et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature. 2012;492:123-7 pubmed publisher
Korboukh I, Hull Ryde E, Rittiner J, Randhawa A, Coleman J, Fitzpatrick B, et al. Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice. J Med Chem. 2012;55:6467-77 pubmed publisher
Kaufman A, Milnerwood A, Sepers M, Coquinco A, She K, Wang L, et al. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. J Neurosci. 2012;32:3992-4003 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Van Hook M, Wong K, Berson D. Dopaminergic modulation of ganglion-cell photoreceptors in rat. Eur J Neurosci. 2012;35:507-18 pubmed publisher
Mitra A, Mitra S, Tsien R. Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity. Nat Neurosci. 2011;15:250-7 pubmed publisher
Benito E, Valor L, Jimenez Minchan M, Huber W, Barco A. cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression. J Neurosci. 2011;31:18237-50 pubmed publisher
Tran E, Sun H, Fang Y. Dynamic mass redistribution assays decode surface influence on signaling of endogenous purinergic P2Y receptors. Assay Drug Dev Technol. 2012;10:37-45 pubmed publisher
Bolognini D, Cascio M, Parolaro D, Pertwee R. AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor. Br J Pharmacol. 2012;165:2561-74 pubmed publisher
Horváth B, Magid L, Mukhopadhyay P, Batkai S, Rajesh M, Park O, et al. A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury. Br J Pharmacol. 2012;165:2462-78 pubmed publisher
Chen Y, Yue S, Xie L, Pu X, Jin T, Cheng S. Dual Phosphorylation of suppressor of fused (Sufu) by PKA and GSK3beta regulates its stability and localization in the primary cilium. J Biol Chem. 2011;286:13502-11 pubmed publisher
Bonetti C, Surace E. Mouse embryonic retina delivers information controlling cortical neurogenesis. PLoS ONE. 2010;5:e15211 pubmed publisher
Schapitz I, Behrend B, Pechmann Y, Lappe Siefke C, Kneussel S, Wallace K, et al. Neuroligin 1 is dynamically exchanged at postsynaptic sites. J Neurosci. 2010;30:12733-44 pubmed publisher
Goffin D, Ali A, Rampersaud N, Harkavyi A, Fuchs C, Whitton P, et al. Dopamine-dependent tuning of striatal inhibitory synaptogenesis. J Neurosci. 2010;30:2935-50 pubmed publisher
Althaus M, Pichl A, Clauss W, Seeger W, Fronius M, Morty R. Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells. Am J Respir Cell Mol Biol. 2011;44:53-65 pubmed publisher
Garavaglia A, Moiana A, Camnasio S, Bolognini D, Papait R, Rigamonti D, et al. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci. 2010;11:7 pubmed publisher
Buznikov G, Nikitina L, Bezuglov V, Francisco M, Boysen G, Obispo Peak I, et al. A putative 'pre-nervous' endocannabinoid system in early echinoderm development. Dev Neurosci. 2010;32:1-18 pubmed publisher
Roscioni S, Kistemaker L, Menzen M, Elzinga C, Gosens R, Halayko A, et al. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res. 2009;10:88 pubmed publisher
Byrnes K, Stoica B, Loane D, Riccio A, Davis M, Faden A. Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. Glia. 2009;57:550-60 pubmed publisher
Rao Y, Liu Z, Borok E, Rabenstein R, Shanabrough M, Lu M, et al. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. J Clin Invest. 2007;117:4022-33 pubmed
Hosoi T, Koguchi Y, Sugikawa E, Chikada A, Ogawa K, Tsuda N, et al. Identification of a novel human eicosanoid receptor coupled to G(i/o). J Biol Chem. 2002;277:31459-65 pubmed
product information
master code :
1099
SKU :
1099/10
product name :
Forskolin
unit size :
10 mg (also 50 mg)
description :
Adenylyl cyclase activator
target :
Adenylyl Cyclase Activators
category :
Small Molecules
purity :
98%
observed molecular weight :
410.51
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Forskolin, or coleonol, is a cell-permeable, potent, reversible and rapid activator of adenylyl cyclase, an enzyme that converts ATP to cAMP and pyrophosphate (EC50 = 0.5 M). In combination with 5 other compounds, forskolin enables chemical reprogramming of mouse embryonic fibroblasts to pluripotent stem cells, without genetic factors: Valproic acid, sodium salt (Cat. No. 2815), RepSox (Cat. No. 3742), Tranylcypromine hydrochloride (Cat. No. 3852), CHIR 99021 (Cat. No. 4423) and 3-Deazaneplanocin A hydrochloride (Cat. No. 4703). In combination with IBMX (Cat. No. 2845), forskolin induces neural differentiation of mesenchymal stem cells by downregulating neuron restrictive silencer factor. In a rat model of Huntington s disease-like neurodegeneration, forskolin also exhibits neuroprotective effects. Hypotensive and vasodilatory agent. . Water-soluble analog, NKH 477 (Cat. No. 1603), and Forskolin synthesized to Ancillary Material Grade also available. . For more information about how Forskolin may be used, see our protocol: Transdifferentiating Fibroblasts into Neurons.
top caption :
Adenylyl cyclase activator
extended description :
Adenylyl cyclase activator
chemical name text :
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
formula :
C22H34O7
formula text :
C22H34O7
cas num :
66575-29-9
USD :
212 USD
product details :
Adenylyl cyclase activator
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK