product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Taxol
catalog :
1097
quantity :
10 mg (also 50 mg)
price :
152 USD
more info or order :
citations: 26
Reference |
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Masocha W. Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice. Peerj. 2016;4:e2702 pubmed
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Kathawala R, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, et al. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 2015;6:510-21 pubmed
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Natrajan R, Mackay A, Wilkerson P, Lambros M, Wetterskog D, Arnedos M, et al. Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res. 2012;14:R53 pubmed
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Pennati M, Campbell A, Curto M, Binda M, Cheng Y, Wang L, et al. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005;4:1328-37 pubmed
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product information
brand :
Tocris
master code :
1097
SKU :
1097/10
product name :
Taxol
description :
Promotes assembly and inhibits disassembly of microtubules
target :
Microtubule Binding Compounds
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
99%
observed molecular weight :
853.92
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.
catalog number base :
1097
product keywords :
Promotes assembly inhibits inhibitors disassembly microtubules Tau Tubulin Mitosis taxanes chemotherapeutics Paclitaxel Microtubules Mitosis Autophagy 1097,
extended description :
Promotes assembly and inhibits disassembly of microtubules
chemical name text :
[2aR-[2a ,4 ,4a ,6 ,9 ( R*, S*),11 ,12 ,12a ,12b ]]- -(Benzoylamino)- -hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetr
formula :
C 47 H 51 NO 14
formula text :
C47H51NO14
cas num :
33069-62-4
2020 USD :
144
2021 USD :
152 USD
alt names :
Paclitaxel
storage :
Store at +4°C
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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