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company name :
Tocris Bioscience
product type :
chemical
product name :
1097/10
catalog :
1097/10
quantity :
10 mg (also 50 mg)
price :
198 USD
more info or order :
citations: 30
Reference
Villalba Riquelme E, de la Torre Martínez R, Fernández Carvajal A, Ferrer Montiel A. Paclitaxel in vitro reversibly sensitizes the excitability of IB4(-) and IB4(+) sensory neurons from male and female rats. Br J Pharmacol. 2022;: pubmed publisher
Wang D, Hou Q, Zhao L, Gao J, Xiao Y, Wang A. Programmed cell death factor 4 enhances the chemosensitivity of colorectal cancer cells to Taxol. Oncol Lett. 2019;18:1402-1408 pubmed publisher
Ayoub N, Al Shami K, Alqudah M, Mhaidat N. Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agents. Onco Targets Ther. 2017;10:4869-4883 pubmed publisher
Kyte S, Toma W, Bagdas D, Meade J, SCHURMAN L, Lichtman A, et al. Nicotine Prevents and Reverses Paclitaxel-Induced Mechanical Allodynia in a Mouse Model of CIPN. J Pharmacol Exp Ther. 2018;364:110-119 pubmed publisher
Wang J, Kong D, Hoerner C, Loncarek J, Stearns T. Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells. elife. 2017;6: pubmed publisher
Zhang H, Patel A, Wang Y, Zhang Y, Kathawala R, Qiu L, et al. The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors. Mol Cancer Ther. 2017;16:1021-1030 pubmed publisher
Masocha W. Gene expression profile of sodium channel subunits in the anterior cingulate cortex during experimental paclitaxel-induced neuropathic pain in mice. Peerj. 2016;4:e2702 pubmed
Rennekamp A, Huang X, Wang Y, Patel S, Lorello P, Cade L, et al. ?1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol. 2016;12:552-8 pubmed publisher
Masocha W. Astrocyte activation in the anterior cingulate cortex and altered glutamatergic gene expression during paclitaxel-induced neuropathic pain in mice. Peerj. 2015;3:e1350 pubmed publisher
Haghshenas B, Nami Y, Haghshenas M, Abdullah N, Rosli R, Radiah D, et al. Bioactivity characterization of Lactobacillus strains isolated from dairy products. Microbiologyopen. 2015;4:803-13 pubmed publisher
Parvathy S, Masocha W. Coadministration of indomethacin and minocycline attenuates established paclitaxel-induced neuropathic thermal hyperalgesia: Involvement of cannabinoid CB1 receptors. Sci Rep. 2015;5:10541 pubmed publisher
Saida Y, Watanabe S, Tanaka T, Baba J, Sato K, Shoji S, et al. Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy. J Immunol. 2015;195:726-35 pubmed publisher
Akita K, Higaki T, Kutsuna N, Hasezawa S. Quantitative analysis of microtubule orientation in interdigitated leaf pavement cells. Plant Signal Behav. 2015;10:e1024396 pubmed publisher
Kathawala R, Wang Y, Shukla S, Zhang Y, Alqahtani S, Kaddoumi A, et al. ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel. Chin J Cancer. 2015;34:115-20 pubmed publisher
Goldmacher V, Audette C, Guan Y, Sidhom E, Shah J, Whiteman K, et al. High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction. PLoS ONE. 2015;10:e0117523 pubmed publisher
Vergara D, De Domenico S, Maffia M, Piro G, Di Sansebastiano G. Transgenic plants as low-cost platform for chemotherapeutic drugs screening. Int J Mol Sci. 2015;16:2174-86 pubmed publisher
Stephan S, Taber A, Jileaeva I, Pegues E, Sentman C, Stephan M. Biopolymer implants enhance the efficacy of adoptive T-cell therapy. Nat Biotechnol. 2015;33:97-101 pubmed publisher
Kathawala R, Wei L, Anreddy N, Chen K, Patel A, Alqahtani S, et al. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 2015;6:510-21 pubmed
Del Nagro C, Xiao Y, Rangell L, Reichelt M, O BRIEN T. Depletion of the central metabolite NAD leads to oncosis-mediated cell death. J Biol Chem. 2014;289:35182-92 pubmed publisher
Habu T, Matsumoto T. p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs. Springerplus. 2013;2:562 pubmed publisher
Floyd S, Whiffin N, Gavilan M, Kutscheidt S, De Luca M, Marcozzi C, et al. Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1. J Cell Sci. 2013;126:2845-56 pubmed publisher
Lin Y, Richards F, Krippendorff B, Bramhall J, Harrington J, Bapiro T, et al. Paclitaxel and CYC3, an aurora kinase A inhibitor, synergise in pancreatic cancer cells but not bone marrow precursor cells. Br J Cancer. 2012;107:1692-701 pubmed publisher
Natrajan R, Mackay A, Wilkerson P, Lambros M, Wetterskog D, Arnedos M, et al. Functional characterization of the 19q12 amplicon in grade III breast cancers. Breast Cancer Res. 2012;14:R53 pubmed
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Gärtner A, Fornasiero E, Munck S, Vennekens K, Seuntjens E, Huttner W, et al. N-cadherin specifies first asymmetry in developing neurons. EMBO J. 2012;31:1893-903 pubmed publisher
Hahm E, Hammond D, PROUDFIT H. Substance P induces the reversible formation of varicosities in the dendrites of rat brainstem neurons. Brain Res. 2011;1369:36-45 pubmed publisher
He M, Zhang Z, Guan C, Xia D, Yuan X. Leading tip drives soma translocation via forward F-actin flow during neuronal migration. J Neurosci. 2010;30:10885-98 pubmed publisher
Lim S, Choi M, Kim M, Kim J. Alpha-tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells. Exp Mol Med. 2009;41:737-45 pubmed publisher
Nieto F, Entrena J, Cendan C, Del Pozo E, Vela J, Baeyens J. Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice. Pain. 2008;137:520-531 pubmed publisher
Pennati M, Campbell A, Curto M, Binda M, Cheng Y, Wang L, et al. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005;4:1328-37 pubmed
product information
master code :
1097
SKU :
1097/10
product name :
Taxol
unit size :
10 mg (also 50 mg)
description :
Promotes assembly and inhibits disassembly of microtubules
target :
Microtubule Binding Compounds
category :
Small Molecules
purity :
98%
observed molecular weight :
853.92
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Taxol, also known as paclitaxel, promotes and stabilizes tubulin polymerization, causing cell cycle arrest. In CCRF-HSB-2 cells, Taxol induces autocatalytic activation of caspase-10, triggering apoptosis. Taxol is an antitumor agent. In a mouse model of bladder cancer Taxol decreases tumor growth. Taxol also prolongs survival of mice transplanted with human ovarian carcinoma xenografts. Taxol improves neurological outcome and magnetic resonance imaging biomarkers after traumatic brain injury in mice.
top caption :
Promotes assembly and inhibits disassembly of microtubules
extended description :
Promotes assembly and inhibits disassembly of microtubules
chemical name text :
[2aR-[2a ,4 ,4a ,6 ,9 ( R*, S*),11 ,12 ,12a ,12b ]]- -(Benzoylamino)- -hydroxy-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetr
formula :
C47H51NO14
formula text :
C47H51NO14
cas num :
33069-62-4
USD :
198 USD
product details :
Promotes assembly and inhibits disassembly of microtubules
alt names :
Paclitaxel
storage :
Store at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK