product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
1088/10
catalog :
1088/10
quantity :
10 mg (also 50 mg)
price :
296 USD
more info or order :
citations: 35
Reference
Goutierre M, Al Awabdh S, Donneger F, François E, Gómez Domínguez D, Irinopoulou T, et al. KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels. Cell Rep. 2019;28:91-103.e7 pubmed publisher
Martelli C, Fiala A. Slow presynaptic mechanisms that mediate adaptation in the olfactory pathway of Drosophila. elife. 2019;8: pubmed publisher
Xiao L, Priest M, Nasenbeny J, Lu T, Kozorovitskiy Y. Biased Oxytocinergic Modulation of Midbrain Dopamine Systems. Neuron. 2017;95:368-384.e5 pubmed publisher
Zhang Y, Reichel J, Han C, Zuniga Hertz J, Cai D. Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight. Cell Metab. 2017;25:1091-1102.e4 pubmed publisher
Lecat Guillet N, Monnier C, Rovira X, Kniazeff J, Lamarque L, Zwier J, et al. FRET-Based Sensors Unravel Activation and Allosteric Modulation of the GABAB Receptor. Cell Chem Biol. 2017;24:360-370 pubmed publisher
Scholler P, Moreno Delgado D, Lecat Guillet N, Doumazane E, Monnier C, Charrier Savournin F, et al. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 2017;13:372-380 pubmed publisher
Lin Y, Wang H, Huang D, Hsieh P, Lin M, Chou C, et al. Neuronal Splicing Regulator RBFOX3 (NeuN) Regulates Adult Hippocampal Neurogenesis and Synaptogenesis. PLoS ONE. 2016;11:e0164164 pubmed publisher
Zhang X, Gaudry Q. Functional integration of a serotonergic neuron in the Drosophila antennal lobe. elife. 2016;5: pubmed publisher
Tachibana S, Touhara K, Ejima A. Modification of Male Courtship Motivation by Olfactory Habituation via the GABAA Receptor in Drosophila melanogaster. PLoS ONE. 2015;10:e0135186 pubmed publisher
Chen M, Zhao Y, Yang H, Luan W, Song J, Cui D, et al. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. elife. 2015;4: pubmed publisher
Bocchio M, Fucsina G, Oikonomidis L, McHugh S, Bannerman D, Sharp T, et al. Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Neuropsychopharmacology. 2015;40:3015-26 pubmed publisher
Zhang W, Xu C, Tu H, Wang Y, Sun Q, Hu P, et al. GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Sci Rep. 2015;5:10468 pubmed publisher
Kotecki L, Hearing M, McCall N, Marron Fernandez de Velasco E, Pravetoni M, Arora D, et al. GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner. J Neurosci. 2015;35:7131-42 pubmed publisher
Chumakov I, Nabirotchkin S, Cholet N, Milet A, Boucard A, Toulorge D, et al. Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy. Sci Rep. 2015;5:7608 pubmed publisher
Nagel K, Hong E, Wilson R. Synaptic and circuit mechanisms promoting broadband transmission of olfactory stimulus dynamics. Nat Neurosci. 2015;18:56-65 pubmed publisher
Hoestgaard Jensen K, Dalby N, Krall J, Hammer H, Krogsgaard Larsen P, Frølund B, et al. Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain. J Neurosci. 2014;34:16256-72 pubmed publisher
Pfeffer C, Xue M, He M, Huang Z, Scanziani M. Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Nat Neurosci. 2013;16:1068-76 pubmed publisher
Zhang Z, Cordeiro Matos S, Jego S, Adamantidis A, Séguéla P. Norepinephrine drives persistent activity in prefrontal cortex via synergistic ?1 and ?2 adrenoceptors. PLoS ONE. 2013;8:e66122 pubmed publisher
Baloucoune G, Chun L, Zhang W, Xu C, Huang S, Sun Q, et al. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation. PLoS ONE. 2012;7:e39698 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Paz J, Bryant A, Peng K, Fenno L, Yizhar O, Frankel W, et al. A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. Nat Neurosci. 2011;14:1167-73 pubmed publisher
Agarwal G, Isacoff E. Specializations of a pheromonal glomerulus in the Drosophila olfactory system. J Neurophysiol. 2011;105:1711-21 pubmed publisher
Werner D, Kumar S, Criswell H, Suryanarayanan A, Fetzer J, Comerford C, et al. PKC? is required for ethanol-induced increases in GABA(A) receptor ?4 subunit expression in cultured cerebral cortical neurons. J Neurochem. 2011;116:554-63 pubmed publisher
Tani H, Dulla C, Huguenard J, Reimer R. Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice. J Neurosci. 2010;30:1288-300 pubmed publisher
Tu H, Xu C, Zhang W, Liu Q, Rondard P, Pin J, et al. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci. 2010;30:749-59 pubmed publisher
Dacks A, Green D, Root C, Nighorn A, Wang J. Serotonin modulates olfactory processing in the antennal lobe of Drosophila. J Neurogenet. 2009;23:366-77 pubmed publisher
Ignell R, Root C, Birse R, Wang J, Nassel D, Winther A. Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila. Proc Natl Acad Sci U S A. 2009;106:13070-5 pubmed publisher
Lorincz M, Geall F, Bao Y, Crunelli V, Hughes S. ATP-dependent infra-slow (<0.1 Hz) oscillations in thalamic networks. PLoS ONE. 2009;4:e4447 pubmed publisher
Root C, Masuyama K, Green D, Enell L, Nassel D, Lee C, et al. A presynaptic gain control mechanism fine-tunes olfactory behavior. Neuron. 2008;59:311-21 pubmed publisher
Binet V, Duthey B, Lecaillon J, Vol C, Quoyer J, Labesse G, et al. Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors. J Biol Chem. 2007;282:12154-63 pubmed
Shang Y, Claridge Chang A, Sjulson L, Pypaert M, Miesenbock G. Excitatory local circuits and their implications for olfactory processing in the fly antennal lobe. Cell. 2007;128:601-12 pubmed
Gascon E, Dayer A, Sauvain M, Potter G, Jenny B, De Roo M, et al. GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb. J Neurosci. 2006;26:12956-66 pubmed
Piet R, Vargova L, Sykova E, Poulain D, Oliet S. Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. Proc Natl Acad Sci U S A. 2004;101:2151-5 pubmed
Dzitoyeva S, Dimitrijevic N, Manev H. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci U S A. 2003;100:5485-90 pubmed
Wood M, Murkitt K, Rice S, Testa T, Punia P, Stammers M, et al. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000;131:1050-4 pubmed
product information
master code :
1088
SKU :
1088/10
product name :
CGP 54626 hydrochloride
unit size :
10 mg (also 50 mg)
description :
Potent and selective GABAB antagonist
target :
GABA-B Receptor Antagonists
category :
Small Molecules
purity :
96%
observed molecular weight :
444.76
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CGP 54626 hydrochloride is a potent, selective GABAB receptor antagonist (IC50 = 4 nM).
top caption :
Potent and selective GABAB antagonist
extended description :
Potent and selective GABAB antagonist
chemical name text :
[S-(R*,R*)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid
formula :
C18H28Cl2NO3P.HCl
formula text :
C18H28Cl2NO3P.HCl
cas num :
149184-21-4
USD :
296 USD
product details :
Potent and selective GABAB antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK