product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Iberiotoxin
catalog :
1086
quantity :
100 ug
price :
333 USD
more info or order :
citations: 15
Reference
Hirono M, Ogawa Y, Misono K, Zollinger D, Trimmer J, Rasband M, et al. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. J Neurosci. 2015;35:7082-94 pubmed publisher
Lai M, Wu Y, Gao Z, Anderson M, Dalziel J, Meredith A. BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo. Am J Physiol Heart Circ Physiol. 2014;307:H1327-38 pubmed publisher
Ok S, Bae S, Kwon S, Park J, Kim W, Park K, et al. Bupivacaine-induced Vasodilation Is Mediated by Decreased Calcium Sensitization in Isolated Endothelium-denuded Rat Aortas Precontracted with Phenylephrine. Korean J Pain. 2014;27:229-38 pubmed publisher
Shukla P, Ghatta S, Dubey N, Lemley C, Johnson M, Modgil A, et al. Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries. Am J Physiol Heart Circ Physiol. 2014;307:H134-42 pubmed publisher
Needham M, McGahon M, Bankhead P, Gardiner T, Scholfield C, Curtis T, et al. The role of K+ and Cl- channels in the regulation of retinal arteriolar tone and blood flow. Invest Ophthalmol Vis Sci. 2014;55:2157-65 pubmed publisher
Grassin Delyle S, Abrial C, Fayad Kobeissi S, Brollo M, Faisy C, Alvarez J, et al. The expression and relaxant effect of bitter taste receptors in human bronchi. Respir Res. 2013;14:134 pubmed publisher
Mannowetz N, Naidoo N, Choo S, Smith J, Lishko P. Slo1 is the principal potassium channel of human spermatozoa. elife. 2013;2:e01009 pubmed publisher
Townsend E, Emala C. Quercetin acutely relaxes airway smooth muscle and potentiates ?-agonist-induced relaxation via dual phosphodiesterase inhibition of PLC? and PDE4. Am J Physiol Lung Cell Mol Physiol. 2013;305:L396-403 pubmed publisher
Kyle B, Bradley E, Large R, Sergeant G, McHale N, Thornbury K, et al. Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists. Am J Physiol Cell Physiol. 2013;305:C609-22 pubmed publisher
Wan E, Kushner J, Zakharov S, Nui X, Chudasama N, Kelly C, et al. Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice. FASEB J. 2013;27:1859-67 pubmed publisher
Pulkkinen V, Manson M, Säfholm J, Adner M, Dahlen S. The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Am J Physiol Lung Cell Mol Physiol. 2012;303:L956-66 pubmed publisher
Lee Y, Chang H, Chiang C, Liu C, Yeh J, Chen M, et al. Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension. Circulation. 2011;124:1160-71 pubmed publisher
Zemkova H, Stojilkovic S, Klein D. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology. 2011;152:3842-51 pubmed publisher
Benvindo O, Nascimento N, Santos C, Fonteles M, Silveira E, Uchoa D, et al. Relaxant effect and possible mechanism of 17-nor-subincanadine E in rabbit corpora cavernosa. Asian J Androl. 2011;13:747-53 pubmed publisher
Tahvildari B, Alonso A, Bourque C. Ionic basis of ON and OFF persistent activity in layer III lateral entorhinal cortical principal neurons. J Neurophysiol. 2008;99:2006-11 pubmed publisher
product information
brand :
Tocris
master code :
1086
SKU :
1086/100U
product name :
Iberiotoxin
description :
KCa (BK) channel blocker
target :
Ca2+-Activated Potassium Channel Blockers
category :
Peptides
unit size :
100 ug
observed molecular weight :
4230
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
Selective blocker of the big conductance Ca2+-activated K+ channel.
catalog number base :
1086
product keywords :
K+ channel blockers high conductance Ca2+-dependent Potassium KCa Channels ca2+-activated ca2+-dependent venoms Ca2+-Activated Potassium Channels 1086,
extended description :
KCa (BK) channel blocker
formula :
C 179 H 274 N 50 O 55 S 7
formula text :
C179H274N50O55S7
cas num :
129203-60-7
2020 USD :
326
2021 USD :
333 USD
storage :
Desiccate at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK