1081/10 | Tocris Bioscience 1081/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1081/10

catalog :

1081/10

quantity :

10 mg (also 50 mg)

price :

199 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Sousa V, Assaife Lopes N, Ribeiro J, Pratt J, Brett R, Sebastião A. Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of ?9-tetrahydrocannabinol on spatial memory. Neuropsychopharmacology. 2011;36:472-87 pubmed publisher

image

image 1 :

Cat.No. 1081 - SKF 89976A hydrochloride C22H25NO2.HCl CAS No. 85375-15-1

product information

master code :

1081

SKU :

1081/10

product name :

SKF 89976A hydrochloride

unit size :

10 mg (also 50 mg)

description :

Potent GAT-1 inhibitor; brain penetrant

target :

GABA Transporter Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

371.91

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SKF 89976A hydrochloride is a potent GABA uptake inhibitor, selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 u M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (Ki = 7 u M) and transmitter-gated current non-competitively (Ki = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo .

top caption :

Potent GAT-1 inhibitor; brain penetrant

extended description :

Potent GAT-1 inhibitor; brain penetrant

chemical name text :

1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride

formula :

C22H25NO2.HCl

formula text :

C22H25NO2.HCl

cas num :

85375-15-1

USD :

199 USD

product details :

Potent GAT-1 inhibitor; brain penetrant

storage :

Desiccate at +4░C

more info or order :

Tocris Bioscience product webpage