AGN 192403 hydrochloride | Tocris Bioscience 1072 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AGN 192403 hydrochloride

catalog :

1072

quantity :

10 mg (also 50 mg)

price :

180 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Dvela Levitt M, Kost Alimova M, Emani M, Kohnert E, Thompson R, Sidhom E, et al. Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell. 2019;178:521-535.e23 pubmed publisher
Sánchez Blázquez P, Boronat M, Olmos G, García Sevilla J, Garzon J. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 2000;130:146-52 pubmed

product information

brand :

Tocris

master code :

1072

SKU :

1072/10

product name :

AGN 192403 hydrochloride

description :

I1 selective ligand

target :

Imidazoline 1 (I1) Receptor Ligands

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

189.73

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

I1 imidazoline binding site selective ligand with a potency at I1 comparable to moxonidine, but devoid of affinity for adrenoceptors and the I2 binding site. Causes none of the physiological responses associated with the I1 binding site in animal models. Also binds TMED9 cargo receptor. Releases MUC1-fs from TMED9 containing vesicles in kidney cells bearing MUC1 gene mutation

catalog number base :

1072

product keywords :

I1 selective ligands Imidazoline Receptors AGN192403 hydrochloride mutant MUC1 mucin-1 TMED9 proteinopathy BRD4780 I1 Receptors Other ER stress/UPR 1072,

extended description :

I1 selective ligand

chemical name text :

( )-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride

formula :

C 10 H 19 N.HCl

formula text :

C10H19N.HCl

cas num :

1021868-90-5

2020 USD :

173

2021 USD :

180 USD

alt names :

BRD4780

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage