1072/10 | Tocris Bioscience 1072/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1072/10

catalog :

1072/10

quantity :

10 mg (also 50 mg)

price :

226 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Dvela Levitt M, Kost Alimova M, Emani M, Kohnert E, Thompson R, Sidhom E, et al. Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell. 2019;178:521-535.e23 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Sánchez Blázquez P, Boronat M, Olmos G, García Sevilla J, Garzon J. Activation of I(2)-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 2000;130:146-52 pubmed

image

image 1 :

Cat.No. 1072 - AGN 192403 hydrochloride C10H19N.HCl CAS No. 1021868-90-5

product information

master code :

1072

SKU :

1072/10

product name :

AGN 192403 hydrochloride

unit size :

10 mg (also 50 mg)

description :

I1 selective ligand

target :

Imidazoline 1 (I1) Receptor Ligands

category :

Small Molecules

observed molecular weight :

189.73

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AGN 192403 hydrochloride is an i1 imidazoline binding site selective ligand with a potency at I1 comparable to moxonidine, but devoid of affinity for adrenoceptors and the I2 binding site. Causes none of the physiological responses associated with the I1 binding site in animal models. Also binds TMED9 cargo receptor. Releases MUC1-fs from TMED9 containing vesicles in kidney cells bearing MUC1 gene mutation

top caption :

I1 selective ligand

extended description :

I1 selective ligand

chemical name text :

( )-2-endo-Amino-3-exo-isopropylbicyclo[2.2.1]heptane hydrochloride

formula :

C10H19N.HCl

formula text :

C10H19N.HCl

cas num :

1021868-90-5

USD :

226 USD

product details :

I1 selective ligand

alt names :

BRD4780

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage