product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Pirenzepine dihydrochloride
catalog :
1071
quantity :
100 mg
price :
85 USD
more info or order :
citations: 16
Reference
Ross J, Bendahmane M, Fletcher M. Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning. Front Behav Neurosci. 2019;13:164 pubmed publisher
Zucca S, Zucca A, Nakano T, Aoki S, Wickens J. Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo. elife. 2018;7: pubmed publisher
Thomson S, Seo S, Barnes S, Louros S, Muscas M, Dando O, et al. Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome. Neuron. 2017;95:550-563.e5 pubmed publisher
Nadal L, Garcia N, Hurtado E, Simó A, Tomas M, Lanuza M, et al. Presynaptic Muscarinic Acetylcholine Receptors and TrkB Receptor Cooperate in the Elimination of Redundant Motor Nerve Terminals during Development. Front Aging Neurosci. 2017;9:24 pubmed publisher
Ahmed M, Vanpatten S, Lakshminrusimha S, Patel H, Coleman T, Al Abed Y. Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models. Physiol Rep. 2016;4: pubmed publisher
Tian M, Xu J, Lei G, Lombroso P, Jackson M, MacDonald J. STEP activation by G?q coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit. Sci Rep. 2016;6:36684 pubmed publisher
Nadal L, Garcia N, Hurtado E, Simó A, Tomas M, Lanuza M, et al. Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction. Mol Brain. 2016;9:67 pubmed publisher
Pediani J, Ward R, Godin A, Marsango S, Milligan G. Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs. J Biol Chem. 2016;291:13132-46 pubmed publisher
Martin H, Bernabeu A, Lassalle O, Bouille C, Beurrier C, Pelissier Alicot A, et al. Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex. Front Cell Neurosci. 2015;9:457 pubmed publisher
Tozzi A, de Iure A, Tantucci M, Durante V, Quiroga Varela A, Giampà C, et al. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci. 2015;9:192 pubmed publisher
Pacini L, De Falco E, Di Bari M, Coccia A, Siciliano C, Ponti D, et al. M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells. Cancer Biol Ther. 2014;15:1489-98 pubmed publisher
Mans R, Warmus B, Smith C, McMahon L. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. J Neurophysiol. 2014;112:2388-97 pubmed publisher
Tozzi A, de Iure A, Marsili V, Romano R, Tantucci M, Di Filippo M, et al. A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. PLoS ONE. 2012;7:e38312 pubmed publisher
Hulme S, Jones O, Ireland D, Abraham W. Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus. J Neurosci. 2012;32:6785-94 pubmed publisher
Garcia N, Tomas M, Santafe M, Besalduch N, Lanuza M, Tomas J. The interaction between tropomyosin-related kinase B receptors and presynaptic muscarinic receptors modulates transmitter release in adult rodent motor nerve terminals. J Neurosci. 2010;30:16514-22 pubmed publisher
Buchanan K, Petrovic M, Chamberlain S, Marrion N, Mellor J. Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels. Neuron. 2010;68:948-63 pubmed publisher
product information
brand :
Tocris
master code :
1071
SKU :
1071/100
product name :
Pirenzepine dihydrochloride
description :
Selective M1 antagonist
target :
mAChR M1 Antagonists
category :
Small Molecules
unit size :
100 mg
purity :
98%
observed molecular weight :
424.33
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
M1 muscarinic receptor selective antagonist. Inverse agonist activity reported.
catalog number base :
1071
product keywords :
Selective M1 muscarinic antagonists Receptors Acetylcholine ACh M1 Receptors 1071,
extended description :
Selective M1 antagonist
chemical name text :
5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
formula :
C 19 H 21 N 5 O 2 .2HCl
formula text :
C19H21N5O2.2HCl
cas num :
29868-97-1
2020 USD :
82
2021 USD :
85 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK