product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
IB-MECA
catalog :
1066
quantity :
5 mg (also 25 mg)
price :
227 USD
more info or order :
citations: 12
Reference
Ledderose C, Hefti M, Chen Y, Bao Y, Seier T, Li L, et al. Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signal. 2016;12:673-685 pubmed
Eusemann T, Willmroth F, Fiebich B, Biber K, van Calker D. Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells. PLoS ONE. 2015;10:e0134934 pubmed publisher
Ford A, Castonguay A, Cottet M, Little J, Chen Z, Symons Liguori A, et al. Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain. J Neurosci. 2015;35:6057-67 pubmed publisher
Janes K, Esposito E, Doyle T, Cuzzocrea S, Tosh D, Jacobson K, et al. A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways. Pain. 2014;155:2560-7 pubmed publisher
He W, Mazumder A, Wilder T, Cronstein B. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J. 2013;27:3446-54 pubmed publisher
Kozma E, Gizewski E, Tosh D, Squarcialupi L, Auchampach J, Jacobson K. Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol. 2013;85:1171-81 pubmed publisher
Stoddart L, Vernall A, Denman J, Briddon S, Kellam B, Hill S. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol. 2012;19:1105-15 pubmed publisher
Park S, Kim M, Kim J, Brown K, Haase V, D Agati V, et al. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int. 2012;82:878-91 pubmed publisher
Keene A, Balasubramanian R, Lloyd J, Shainberg A, Jacobson K. Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor. Biochem Pharmacol. 2010;80:188-96 pubmed publisher
Kornerup K, Page C, Moffatt J. Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge. Br J Pharmacol. 2005;144:1011-6 pubmed
Feoktistov I, Ryzhov S, Goldstein A, Biaggioni I. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors. Circ Res. 2003;92:485-92 pubmed
Nieri P, Martinotti E, Calderone V, Breschi M. Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. Br J Pharmacol. 2001;134:745-52 pubmed
product information
brand :
Tocris
master code :
1066
SKU :
1066/5
product name :
IB-MECA
description :
A3 selective agonist
target :
Adenosine A3 Receptor Agonists
category :
Small Molecules
unit size :
5 mg (also 25 mg)
purity :
97%
observed molecular weight :
510.29
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent and selective A3 adenosine receptor agonist (Ki values are 1.1, 54 and 56 nM for A3, A1 and A2A receptors respectively). Cardioprotective, reduces infarct size upon reperfusion in rats.
catalog number base :
1066
product keywords :
A3 selective agonists Receptors adenosines CF 101 Piclidenoson Adenosine A3 Receptors 1066,
extended description :
A3 selective agonist
chemical name text :
1-Deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl- -D-ribofuranuronamide
formula :
C 18 H 19 IN 6 O 4
formula text :
C18H19IN6O4
cas num :
152918-18-8
2020 USD :
218
2021 USD :
227 USD
alt names :
CF 101, Piclidenoson
storage :
Desiccate at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK