PD 168077 maleate | Tocris Bioscience 1065 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 168077 maleate

catalog :

1065

quantity :

10 mg (also 50 mg)

price :

169 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Negrete Díaz J, Shumilov K, Real M, Medina Luque J, Valderrama Carvajal A, Flores G, et al. Pharmacological activation of dopamine D4 receptor modulates morphine-induced changes in the expression of GAD65/67 and GABAB receptors in the basal ganglia. Neuropharmacology. 2019;: pubmed publisher
Dai H, Jackson C, Davis G, Blakely R, McMahon D. Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model. J Neurodev Disord. 2017;9:38 pubmed publisher
Guo F, Zhao J, Zhao D, Wang J, Wang X, Feng Z, et al. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell. 2017;16:1323-1333 pubmed publisher
Huang M, Kwon S, He W, Meltzer H. Neurochemical arguments for the use of dopamine D4 receptor stimulation to improve cognitive impairment associated with schizophrenia. Pharmacol Biochem Behav. 2017;157:16-23 pubmed publisher
Chen K, Deng K, Wang X, Wang Z, Zheng S, Ren H, et al. Activation of D4 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Hypertension. 2015;65:153-60 pubmed publisher
Yuen E, Zhong P, Li X, Wei J, Yan Z. Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals. J Biol Chem. 2013;288:26112-20 pubmed publisher
Graziane N, Yuen E, Yan Z. Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism. J Biol Chem. 2009;284:8329-36 pubmed publisher

product information

brand :

Tocris

master code :

1065

SKU :

1065/10

product name :

PD 168077 maleate

description :

High affinity, selective D4 agonist

target :

Dopamine D4 Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

450.49

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A potent D4 dopamine receptor agonist (Ki = 8.7 nM) with 400-fold selectivity over D2 and 300-fold selectivity versus D3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo .

catalog number base :

1065

product keywords :

High affinity selective D4 agonists Dopamine Receptors dopaminergic PD168077 maleate D4 Receptors 1065,

extended description :

High affinity, selective D4 agonist

chemical name text :

N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamide maleate

formula :

C 20 H 22 N 4 O.C 4 H 4 O 4

formula text :

C20H22N4O.C4H4O4

cas num :

630117-19-0

2020 USD :

162

2021 USD :

169 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage