1065/10 | Tocris Bioscience 1065/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1065/10

catalog :

1065/10

quantity :

10 mg (also 50 mg)

price :

214 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Negrete Díaz J, Shumilov K, Real M, Medina Luque J, Valderrama Carvajal A, Flores G, et al. Pharmacological activation of dopamine D4 receptor modulates morphine-induced changes in the expression of GAD65/67 and GABAB receptors in the basal ganglia. Neuropharmacology. 2019;: pubmed publisher
Dai H, Jackson C, Davis G, Blakely R, McMahon D. Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model. J Neurodev Disord. 2017;9:38 pubmed publisher
Guo F, Zhao J, Zhao D, Wang J, Wang X, Feng Z, et al. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell. 2017;16:1323-1333 pubmed publisher
Huang M, Kwon S, He W, Meltzer H. Neurochemical arguments for the use of dopamine D4 receptor stimulation to improve cognitive impairment associated with schizophrenia. Pharmacol Biochem Behav. 2017;157:16-23 pubmed publisher
Boucrot E, Ferreira A, Almeida Souza L, Debard S, Vallis Y, Howard G, et al. Endophilin marks and controls a clathrin-independent endocytic pathway. Nature. 2015;517:460-5 pubmed publisher
Chen K, Deng K, Wang X, Wang Z, Zheng S, Ren H, et al. Activation of D4 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Hypertension. 2015;65:153-60 pubmed publisher
Mikulak J, Bozzo L, Roberto A, Pontarini E, Tentorio P, Hudspeth K, et al. Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor. J Immunol. 2014;193:2792-800 pubmed publisher
Yuen E, Zhong P, Li X, Wei J, Yan Z. Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals. J Biol Chem. 2013;288:26112-20 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Graziane N, Yuen E, Yan Z. Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism. J Biol Chem. 2009;284:8329-36 pubmed publisher

image

image 1 :

Cat.No. 1065 - PD 168077 maleate C20H22N4O.C4H4O4 CAS No. 630117-19-0

product information

master code :

1065

SKU :

1065/10

product name :

PD 168077 maleate

unit size :

10 mg (also 50 mg)

description :

High affinity, selective D4 agonist

target :

Dopamine D4 Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

450.49

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PD 168077 maleate is a potent D4 dopamine receptor agonist (Ki = 8.7 nM) with 400-fold selectivity over D2 and 300-fold selectivity versus D3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo .

top caption :

High affinity, selective D4 agonist

extended description :

High affinity, selective D4 agonist

chemical name text :

N-[[4-(2-Cyanophenyl)-1-piperazinyl]methyl]-3-methylbenzamide maleate

formula :

C20H22N4O.C4H4O4

formula text :

C20H22N4O.C4H4O4

cas num :

630117-19-0

USD :

214 USD

product details :

High affinity, selective D4 agonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage