| Reference |
|---|
Monticone G, Huang Z, Csibi F, Leit S, Ciccone D, Champhekar A, et al. Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses. Front Immunol. 2022;13:987298 pubmed publisher |
Xu X, Beleza R, Gon xe7 alves F, Valbuena S, Al xe7 ada Morais S, Gon xe7 alves N, et al. Adenosine A2A receptors control synaptic remodeling in the adult brain. Sci Rep. 2022;12:14690 pubmed publisher |
De Nuccio C, Bernardo A, Ferrante A, Pepponi R, Martire A, Falchi M, et al. Adenosine A2A receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes. Sci Rep. 2019;9:9782 pubmed publisher |
Kong X, Zuo Y, Huang Y, Ge J. Adenosine A2a receptor agonist CGS21680 treatment attenuates cardiopulmonary bypass‑associated inflammatory lung injury in juvenile rats. Mol Med Rep. 2019;20:117-124 pubmed publisher |
Shifrut E, Carnevale J, Tobin V, Roth T, Woo J, Bui C, et al. Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Cell. 2018;175:1958-1971.e15 pubmed publisher |
Núñez F, Taura J, Camacho J, López Cano M, Fernández Dueñas V, Castro N, et al. PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders. Front Pharmacol. 2018;9:1200 pubmed publisher |
Jain S, Panyutin A, Liu N, Xiao C, Pinol R, Pundir P, et al. Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab. 2018;315:E357-E366 pubmed publisher |
Nakashima K, Iwao K, Inoue T, Haga A, Tsutsumi T, Mochita M, et al. Stimulation of the adenosine A3 receptor, not the A1 or A2 receptors, promote neurite outgrowth of retinal ganglion cells. Exp Eye Res. 2018;170:160-168 pubmed publisher |
Bakhshayesh M, Golab F, Kermanian F, Mehdizadeh M, Katebi A, Soleimani M, et al. The Mediating Role of A2A Adenosine Receptors in the Mitochondrial Pathway of Apoptotic Hippocampal Cell Death, Following the Administration of MDMA in Rat. Basic Clin Neurosci. 2017;8:317-324 pubmed publisher |
Lee D, Preble J, Lee S, Foster C, Taylor A. MC5r and A2Ar Deficiencies During Experimental Autoimmune Uveitis Identifies Distinct T cell Polarization Programs and a Biphasic Regulatory Response. Sci Rep. 2016;6:37790 pubmed publisher |
Liu Y, Yang T, Zhao L, Ni Z, Yang N, He F, et al. Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome. Sci Rep. 2016;6:33614 pubmed publisher |
Ledderose C, Hefti M, Chen Y, Bao Y, Seier T, Li L, et al. Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signal. 2016;12:673-685 pubmed |
Caiazzo E, Maione F, Morello S, Lapucci A, Paccosi S, Steckel B, et al. Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide. Biochem Pharmacol. 2016;112:72-81 pubmed publisher |
Polito M, Guiot E, Gangarossa G, Longueville S, Doulazmi M, Valjent E, et al. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). Eneuro. 2015;2: pubmed publisher |
Perez Aso M, Montesinos M, Mediero A, Wilder T, Schafer P, Cronstein B. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015;17:249 pubmed publisher |
Eusemann T, Willmroth F, Fiebich B, Biber K, van Calker D. Adenosine Receptors Differentially Regulate the Expression of Regulators of G-Protein Signalling (RGS) 2, 3 and 4 in Astrocyte-Like Cells. PLoS ONE. 2015;10:e0134934 pubmed publisher |
Kermanian F, Soleimani M, Pourheydar B, Samzadeh Kermani A, Mohammadzadeh F, Mehdizadeh M. Effects of adenosine A2a receptor agonist and antagonist on cerebellar nuclear factor-kB expression preceded by MDMA toxicity. Med J Islam Repub Iran. 2014;28:120 pubmed |
Welihinda A, Amento E. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond). 2014;11:37 pubmed publisher |
Wydra K, Suder A, Borroto Escuela D, Filip M, Fuxe K. On the role of Aâ‚‚A and Dâ‚‚ receptors in control of cocaine and food-seeking behaviors in rats. Psychopharmacology (Berl). 2015;232:1767-78 pubmed publisher |
Tosolini M, Pont F, Bétous D, Ravet E, Ligat L, Lopez F, et al. Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Mol Cell Biol. 2015;35:479-95 pubmed publisher |
Kavanagh K, Schreiner D, Levis S, O Neill C, Bachtell R. Role of adenosine receptor subtypes in methamphetamine reward and reinforcement. Neuropharmacology. 2015;89:265-73 pubmed publisher |
Ferreira S, Gonçalves F, Marques J, Tomé Ã, Rodrigues R, Nunes Correia I, et al. Presynaptic adenosine A2A receptors dampen cannabinoid CB1 receptor-mediated inhibition of corticostriatal glutamatergic transmission. Br J Pharmacol. 2015;172:1074-86 pubmed publisher |
Chen Z, Xiong C, Pancyr C, Stockwell J, Walz W, Cayabyab F. Prolonged adenosine A1 receptor activation in hypoxia and pial vessel disruption focal cortical ischemia facilitates clathrin-mediated AMPA receptor endocytosis and long-lasting synaptic inhibition in rat hippocampal CA3-CA1 synapses: differential re. J Neurosci. 2014;34:9621-43 pubmed publisher |
Persson P, Hansell P, Palm F. Reduced adenosine A2a receptor-mediated efferent arteriolar vasodilation contributes to diabetes-induced glomerular hyperfiltration. Kidney Int. 2015;87:109-15 pubmed publisher |
Perígolo Vicente R, Ritt K, Gonçalves de Albuquerque C, Castro Faria Neto H, Paes de Carvalho R, Giestal de Araujo E. IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection. Biochem Biophys Res Commun. 2014;449:477-82 pubmed publisher |
Li H, Chuang A, O BRIEN J. Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina. Vis Neurosci. 2014;31:237-43 pubmed publisher |
Ahsan M, Mehal W. Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb. Front Pharmacol. 2014;5:69 pubmed publisher |
Ruby C, Vadnie C, Hinton D, Abulseoud O, Walker D, O Connor K, et al. Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light. Neuropsychopharmacology. 2014;39:2432-40 pubmed publisher |
O Neill C, Hobson B, Levis S, Bachtell R. Persistent reduction of cocaine seeking by pharmacological manipulation of adenosine A1 and A 2A receptors during extinction training in rats. Psychopharmacology (Berl). 2014;231:3179-88 pubmed publisher |
Ziemli ska E, K gler S, Schachner M, Wewi r I, Czarkowska Bauch J, Skup M. Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. PLoS ONE. 2014;9:e88833 pubmed publisher |
Subramanian M, Kini R, Madasu M, Ohta A, Nowak M, Exley M, et al. Extracellular adenosine controls NKT-cell-dependent hepatitis induction. Eur J Immunol. 2014;44:1119-29 pubmed publisher |
Ouyang X, Ghani A, Malik A, Wilder T, COLEGIO O, Flavell R, et al. Adenosine is required for sustained inflammasome activation via the A?A receptor and the HIF-1? pathway. Nat Commun. 2013;4:2909 pubmed publisher |
Matos M, Augusto E, Agostinho P, Cunha R, Chen J. Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-?2 controlling glutamate uptake in astrocytes. J Neurosci. 2013;33:18492-502 pubmed publisher |
Thomas R, Lee J, Chevalier V, Sadler S, Selesniemi K, Hatfield S, et al. Design and evaluation of xanthine based adenosine receptor antagonists: potential hypoxia targeted immunotherapies. Bioorg Med Chem. 2013;21:7453-64 pubmed publisher |
Jeon S, Bak H, Seo J, Han S, Lee S, Han S, et al. Oroxylin A Induces BDNF Expression on Cortical Neurons through Adenosine A2A Receptor Stimulation: A Possible Role in Neuroprotection. Biomol Ther (Seoul). 2012;20:27-35 pubmed publisher |
Lee D, Taylor A. Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice. J Immunol. 2013;191:4103-11 pubmed publisher |
Koscsó B, Csóka B, Kókai E, Németh Z, Pacher P, Virag L, et al. Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol. 2013;94:1309-15 pubmed publisher |
Yang Z, Wang B, Kwansa H, Heitmiller K, Hong G, Carter E, et al. Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet. J Cereb Blood Flow Metab. 2013;33:1612-20 pubmed publisher |
Loram L, Taylor F, Strand K, Harrison J, Rzasalynn R, Sholar P, et al. Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling. Brain Behav Immun. 2013;33:112-22 pubmed publisher |
Bao Y, Chen Y, Ledderose C, Li L, Junger W. Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils. J Biol Chem. 2013;288:22650-7 pubmed publisher |
He W, Mazumder A, Wilder T, Cronstein B. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J. 2013;27:3446-54 pubmed publisher |
Vincenzi F, Corciulo C, Targa M, Merighi S, Gessi S, Casetta I, et al. Multiple sclerosis lymphocytes upregulate A2A adenosine receptors that are antiinflammatory when stimulated. Eur J Immunol. 2013;43:2206-16 pubmed publisher |
Wiseman S, Shimizu Y, Palfrey C, Nairn A. Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCF?TRCP ubiquitin E3 ligase. J Biol Chem. 2013;288:17803-11 pubmed publisher |
Garção P, Szabó E, Wopereis S, Castro A, Tome A, Prediger R, et al. Functional interaction between pre-synaptic ?6?2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum. Br J Pharmacol. 2013;169:1600-11 pubmed publisher |
Fernández Dueñas V, Gómez Soler M, Morató X, Núñez F, Das A, Kumar T, et al. Dopamine D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework. Neurochem Int. 2013;63:42-6 pubmed publisher |
Xiao H, Shen H, Liu W, Xiong R, Li P, Meng G, et al. Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy. PLoS ONE. 2013;8:e60173 pubmed publisher |
Kozma E, Gizewski E, Tosh D, Squarcialupi L, Auchampach J, Jacobson K. Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor. Biochem Pharmacol. 2013;85:1171-81 pubmed publisher |
Aggarwal N, D Alessio F, Eto Y, Chau E, Avalos C, Waickman A, et al. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol. 2013;48:635-46 pubmed publisher |
Fernández Dueñas V, Gómez Soler M, Jacobson K, Kumar S, Fuxe K, Borroto Escuela D, et al. Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R. J Neurochem. 2012;123:373-84 pubmed publisher |
Moidunny S, Vinet J, Wesseling E, Bijzet J, Shieh C, Van IJzendoorn S, et al. Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity. J Neuroinflammation. 2012;9:198 pubmed |
Mills J, Alabanza L, Mahamed D, Bynoe M. Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis. J Neuroinflammation. 2012;9:193 pubmed |
Kan Y, Okabayashi T, Yokota S, Yamamoto S, Fujii N, Yamashita T. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012;86:10338-46 pubmed publisher |
Hobson B, Merritt K, Bachtell R. Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to dopamine D2 receptors in rats. Neuropharmacology. 2012;63:1172-81 pubmed publisher |
Lee Y, Yang Y, Huang C, Kuo T, Lin J, Yang D, et al. When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?. PLoS ONE. 2012;7:e38865 pubmed publisher |
Park S, Kim M, Kim J, Brown K, Haase V, D Agati V, et al. Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia. Kidney Int. 2012;82:878-91 pubmed publisher |
Mediero A, Frenkel S, Wilder T, He W, Mazumder A, Cronstein B. Adenosine A2A receptor activation prevents wear particle-induced osteolysis. Sci Transl Med. 2012;4:135ra65 pubmed publisher |
Li N, Mu L, Wang J, Zhang J, Xie X, Kong Q, et al. Activation of the adenosine A2A receptor attenuates experimental autoimmune myasthenia gravis severity. Eur J Immunol. 2012;42:1140-51 pubmed publisher |
O Neill C, Letendre M, Bachtell R. Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats. Neuropsychopharmacology. 2012;37:1245-56 pubmed publisher |
Garcia G, Truong L, Chen J, Johnson R, Feng L. Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation. Kidney Int. 2011;80:378-88 pubmed publisher |
Kiebala M, Maggirwar S. Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells. PLoS ONE. 2011;6:e18633 pubmed publisher |
Ru F, Surdenikova L, Brozmanova M, Kollarik M. Adenosine-induced activation of esophageal nociceptors. Am J Physiol Gastrointest Liver Physiol. 2011;300:G485-93 pubmed publisher |
Carlström M, Wilcox C, Welch W. Adenosine A2A receptor activation attenuates tubuloglomerular feedback responses by stimulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol. 2011;300:F457-64 pubmed publisher |
Wang Z, Che P, Du J, Ha B, Yarema K. Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385. PLoS ONE. 2010;5:e13883 pubmed publisher |
Su Y, Jackson E, Gorelik E. Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes. Cancer Immunol Immunother. 2011;60:111-22 pubmed publisher |
Higley M, Sabatini B. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci. 2010;13:958-66 pubmed publisher |
Gebremedhin D, Weinberger B, Lourim D, Harder D. Adenosine can mediate its actions through generation of reactive oxygen species. J Cereb Blood Flow Metab. 2010;30:1777-90 pubmed publisher |
Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, et al. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest. 2010;120:2280-91 pubmed publisher |
Das A, Sanjayan G, Kecskés M, Yoo L, Gao Z, Jacobson K. Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists. J Nanobiotechnology. 2010;8:11 pubmed publisher |
Keene A, Balasubramanian R, Lloyd J, Shainberg A, Jacobson K. Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptor. Biochem Pharmacol. 2010;80:188-96 pubmed publisher |
Garavaglia A, Moiana A, Camnasio S, Bolognini D, Papait R, Rigamonti D, et al. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci. 2010;11:7 pubmed publisher |
Nowak M, Lynch L, Yue S, Ohta A, Sitkovsky M, Balk S, et al. The A2aR adenosine receptor controls cytokine production in iNKT cells. Eur J Immunol. 2010;40:682-7 pubmed publisher |
Hiranita T, Soto P, Tanda G, Katz J. Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine. J Pharmacol Exp Ther. 2010;332:515-24 pubmed publisher |
Ohta A, Ohta A, Madasu M, Kini R, Subramanian M, Goel N, et al. A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments. J Immunol. 2009;183:5487-93 pubmed publisher |
Xi J, McIntosh R, Shen X, Lee S, Chanoit G, Criswell H, et al. Adenosine A2A and A2B receptors work in concert to induce a strong protection against reperfusion injury in rat hearts. J Mol Cell Cardiol. 2009;47:684-90 pubmed publisher |
Pugliese A, Traini C, Cipriani S, Gianfriddo M, Mello T, Giovannini M, et al. The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices. Br J Pharmacol. 2009;157:818-30 pubmed publisher |
Epperson S, Brunton L, Ramirez Sanchez I, Villarreal F. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol. 2009;296:C1171-7 pubmed publisher |
Shen W, Flajolet M, Greengard P, Surmeier D. Dichotomous dopaminergic control of striatal synaptic plasticity. Science. 2008;321:848-51 pubmed publisher |
Garcia G, Truong L, Li P, Zhang P, Du J, Chen J, et al. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. FASEB J. 2008;22:445-54 pubmed |
Yang D, Zhang Y, Nguyen H, Koupenova M, Chauhan A, Makitalo M, et al. The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. J Clin Invest. 2006;116:1913-23 pubmed |
Keir S, Boswell Smith V, Spina D, Page C. Mechanism of adenosine-induced airways obstruction in allergic guinea pigs. Br J Pharmacol. 2006;147:720-8 pubmed |
Kornerup K, Page C, Moffatt J. Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge. Br J Pharmacol. 2005;144:1011-6 pubmed |
Germack R, Dickenson J. Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes. Br J Pharmacol. 2004;141:329-39 pubmed |
Nieri P, Martinotti E, Calderone V, Breschi M. Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. Br J Pharmacol. 2001;134:745-52 pubmed |
Ezeamuzie C, Philips E. Adenosine A3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release. Br J Pharmacol. 1999;127:188-94 pubmed |
