product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
GR 55562 dihydrochloride
catalog :
1054
quantity :
10 mg (also 50 mg)
price :
193 USD
more info or order :
citations: 9
Reference
Zhou M, Sun F, Xu C, Chen H, Qiao H, Cai X, et al. Modulation of Kalirin-7 expression by hippocampal CA1 5-HT1B receptors in spatial memory consolidation. Behav Brain Res. 2019;356:148-155 pubmed publisher
Rataj K, Kelemen Á, Brea J, Loza M, Bojarski A, Keseru G. Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands. Molecules. 2018;23: pubmed publisher
Medrihan L, Sagi Y, Inde Z, Krupa O, Daniels C, Peyrache A, et al. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron. 2017;95:564-576.e4 pubmed publisher
Johansson S, Povlsen G, Edvinsson L. Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia. PLoS ONE. 2012;7:e41852 pubmed publisher
Wei L, Liu Y, Kaneto H, Fanburg B. JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2010;298:L863-9 pubmed publisher
Guo J, Rainnie D. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience. 2010;165:1390-401 pubmed publisher
Morecroft I, Pang L, Baranowska M, Nilsen M, Loughlin L, Dempsie Y, et al. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovasc Res. 2010;85:593-603 pubmed publisher
Müller T, Dürk T, Blumenthal B, Grimm M, Cicko S, Panther E, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS ONE. 2009;4:e6453 pubmed publisher
McDaid J, Docherty J. Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat. Br J Pharmacol. 2001;133:429-37 pubmed
product information
brand :
Tocris
master code :
1054
SKU :
1054/10
product name :
GR 55562 dihydrochloride
description :
5-HT1B antagonist
target :
5-HT1B Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
448.39
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
A selective competitive 5-HT1B (5-HT1D ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes.
catalog number base :
1054
product keywords :
5-HT1B antagonists Serotonin Receptors GR55562 dihydrochloride GlaxoSmithKline GSK 5-HT1B Receptors 1054,
extended description :
5-HT1B antagonist
chemical name text :
3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride
formula :
C 23 H 25 N 3 O 2 .2HCl
formula text :
C23H25N3O2.2HCl
cas num :
159533-25-2
2020 USD :
185
2021 USD :
193 USD
storage :
Desiccate at +4°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK