1054/10 | Tocris Bioscience 1054/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1054/10

catalog :

1054/10

quantity :

10 mg (also 50 mg)

price :

243 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Zhou M, Sun F, Xu C, Chen H, Qiao H, Cai X, et al. Modulation of Kalirin-7 expression by hippocampal CA1 5-HT1B receptors in spatial memory consolidation. Behav Brain Res. 2019;356:148-155 pubmed publisher
Rataj K, Kelemen Á, Brea J, Loza M, Bojarski A, Keseru G. Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands. Molecules. 2018;23: pubmed publisher
Medrihan L, Sagi Y, Inde Z, Krupa O, Daniels C, Peyrache A, et al. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron. 2017;95:564-576.e4 pubmed publisher
Tung S, Hardy A, Wheeler M, Belsham D. Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor. Endocrinology. 2012;153:4862-73 pubmed
Johansson S, Povlsen G, Edvinsson L. Expressional changes in cerebrovascular receptors after experimental transient forebrain ischemia. PLoS ONE. 2012;7:e41852 pubmed publisher
Wei L, Liu Y, Kaneto H, Fanburg B. JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2010;298:L863-9 pubmed publisher
Guo J, Rainnie D. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience. 2010;165:1390-401 pubmed publisher
Morecroft I, Pang L, Baranowska M, Nilsen M, Loughlin L, Dempsie Y, et al. In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovasc Res. 2010;85:593-603 pubmed publisher
Müller T, Dürk T, Blumenthal B, Grimm M, Cicko S, Panther E, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS ONE. 2009;4:e6453 pubmed publisher
McDaid J, Docherty J. Vascular actions of MDMA involve alpha1 and alpha2-adrenoceptors in the anaesthetized rat. Br J Pharmacol. 2001;133:429-37 pubmed

image

image 1 :

Cat.No. 1054 - GR 55562 dihydrochloride C23H25N3O2.2HCl CAS No. 159533-25-2

product information

master code :

1054

SKU :

1054/10

product name :

GR 55562 dihydrochloride

unit size :

10 mg (also 50 mg)

description :

5-HT1B antagonist

target :

5-HT1B Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

448.39

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GR 55562 dihydrochloride is a selective competitive 5-HT1B (5-HT1D ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes.

top caption :

5-HT1B antagonist

extended description :

5-HT1B antagonist

chemical name text :

3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrochloride

formula :

C23H25N3O2.2HCl

formula text :

C23H25N3O2.2HCl

cas num :

159533-25-2

USD :

243 USD

product details :

5-HT1B antagonist

storage :

Desiccate at +4░C

more info or order :

Tocris Bioscience product webpage