product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1052/10
catalog :
1052/10
quantity :
10 mg (also 50 mg)
price :
251 USD
more info or order :
citations: 13
Reference
Montgomery M, Chan T, Swigart P, Myagmar B, Dash R, Simpson P. An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice. PLoS ONE. 2017;12:e0168409 pubmed publisher
Thomas R, Singh A, Cowley P, Myagmar B, Montgomery M, Swigart P, et al. A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC Basic Transl Sci. 2016;1:155-167 pubmed
Thomas R, Cowley P, Singh A, Myagmar B, Swigart P, Baker A, et al. The Alpha-1A Adrenergic Receptor in the Rabbit Heart. PLoS ONE. 2016;11:e0155238 pubmed publisher
Treen A, Luo V, Chalmers J, Dalvi P, Tran D, Ye W, et al. Divergent Regulation of ER and Kiss Genes by 17β-Estradiol in Hypothalamic ARC Versus AVPV Models. Mol Endocrinol. 2016;30:217-33 pubmed publisher
Copik A, Baldys A, Nguyen K, Sahdeo S, Ho H, Kosaka A, et al. Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. PLoS ONE. 2015;10:e0115701 pubmed publisher
Desir G, Peixoto A. Renalase in hypertension and kidney disease. Nephrol Dial Transplant. 2014;29:22-8 pubmed publisher
Amirak E, Fuller S, Sugden P, Clerk A. p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and ?(1)-adrenergic receptor agonists. Biochem J. 2013;450:351-63 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Dash R, Chung J, Chan T, Yamada M, Barral J, Nishimura D, et al. A molecular MRI probe to detect treatment of cardiac apoptosis in vivo. Magn Reson Med. 2011;66:1152-62 pubmed publisher
Jensen B, Swigart P, Montgomery M, Simpson P. Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2010;382:475-82 pubmed publisher
Jensen B, Swigart P, Laden M, DeMarco T, Hoopes C, Simpson P. The alpha-1D Is the predominant alpha-1-adrenergic receptor subtype in human epicardial coronary arteries. J Am Coll Cardiol. 2009;54:1137-45 pubmed publisher
O Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, et al. Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. Circ Res. 2008;102:1378-88 pubmed publisher
Rokosh D, Simpson P. Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Proc Natl Acad Sci U S A. 2002;99:9474-9 pubmed
product information
master code :
1052
SKU :
1052/10
product name :
A 61603 hydrobromide
unit size :
10 mg (also 50 mg)
description :
1A agonist
target :
Adrenergic alpha-1 Receptor Agonists
category :
Small Molecules
observed molecular weight :
390.29
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
A 61603 hydrobromide is a potent -adrenoceptor agonist that is at least 35-fold more potent at 1A than at 1B or 1D sites. Induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nmol/L).
top caption :
1A agonist
extended description :
1A agonist
chemical name text :
N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide
formula :
C14H19N3O3S.HBr
formula text :
C14H19N3O3S.HBr
cas num :
107756-30-9
USD :
251 USD
product details :
1A agonist
storage :
Desiccate at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK