product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1050/10
catalog :
1050/10
quantity :
10 mg (also 50 mg)
price :
251 USD
more info or order :
citations: 15
Reference
Lee S, Cho P, Tonello R, Lee H, Jang J, Park G, et al. Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice. J Allergy Clin Immunol. 2018;: pubmed publisher
Moutkine I, Quentin E, Guiard B, Maroteaux L, Doly S. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers. J Biol Chem. 2017;292:6352-6368 pubmed publisher
Gerhold K, Drdla Schutting R, Honsek S, Forsthuber L, Sandkühler J. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 2015;35:9580-94 pubmed publisher
Bocchio M, Fucsina G, Oikonomidis L, McHugh S, Bannerman D, Sharp T, et al. Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Neuropsychopharmacology. 2015;40:3015-26 pubmed publisher
Ward R, Pediani J, Godin A, Milligan G. Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis. J Biol Chem. 2015;290:12844-57 pubmed publisher
Schellekens H, van Oeffelen W, Dinan T, Cryan J. Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem. 2013;288:181-91 pubmed publisher
Austgen J, Dantzler H, Barger B, Kline D. 5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii. J Neurophysiol. 2012;108:2292-305 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Bigford G, Chaudhry N, Keane R, Holohean A. 5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-methyl-D-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization. J Biol Chem. 2012;287:11049-59 pubmed publisher
Murray K, Stephens M, Rank M, D Amico J, Gorassini M, Bennett D. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011;106:925-43 pubmed publisher
Moya P, Fox M, Jensen C, LaPorte J, French H, Wendland J, et al. Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice. BMC Pharmacol. 2011;11:3 pubmed publisher
Yu H, Yamaguchi A. Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis. J Neurophysiol. 2010;103:648-58 pubmed publisher
Yu H, Yamaguchi A. 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. J Neurophysiol. 2009;102:752-65 pubmed publisher
Prahalad P, Calvo I, Waechter H, Matthews J, Zuk A, Matlin K. Regulation of MDCK cell-substratum adhesion by RhoA and myosin light chain kinase after ATP depletion. Am J Physiol Cell Physiol. 2004;286:C693-707 pubmed
Marchese G, Casti P, Ruiu S, Saba P, Sanna A, Casu G, et al. Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications. Br J Pharmacol. 2003;140:520-6 pubmed
product information
master code :
1050
SKU :
1050/10
product name :
RS 102221 hydrochloride
unit size :
10 mg (also 50 mg)
description :
Selective 5-HT2C antagonist
target :
5-HT2C Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
649.08
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
RS 102221 hydrochloride is a potent and selective 5-HT2C antagonist (pKi = 8.7). Displays ~ 100-fold selectivity over the 5-HT2A and 5-HT2B subtypes and is 100-fold selective over other 5-HT receptors, - and -adrenergic and muscarinic ACh receptors.
top caption :
Selective 5-HT2C antagonist
extended description :
Selective 5-HT2C antagonist
chemical name text :
8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride
formula :
C27H31F3N4O7S.HCl
formula text :
C27H31F3N4O7S.HCl
cas num :
187397-18-8
USD :
251 USD
product details :
Selective 5-HT2C antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK