product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1049/10
catalog :
1049/10
quantity :
10 mg (also 50 mg)
price :
156 USD
more info or order :
citations: 18
Reference
David Pereira A, Sagalajev B, Wei H, Almeida A, Pertovaara A, Pinto Ribeiro F. The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience. 2017;349:341-354 pubmed publisher
Tang W, Szokol K, Jensen V, Enger R, Trivedi C, Hvalby Ø, et al. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci. 2015;35:3016-21 pubmed publisher
Loane D, Stoica B, Byrnes K, Jeong W, Faden A. Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury. J Neurotrauma. 2013;30:403-12 pubmed publisher
Liu M, Matsuura S, Shinoda M, Honda K, Suzuki I, Shibuta K, et al. Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord. J Neuroinflammation. 2012;9:258 pubmed publisher
Rojas A, Wetherington J, Shaw R, Serrano G, Swanger S, Dingledine R. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol. 2013;83:106-21 pubmed publisher
Hino H, Takahashi H, Suzuki Y, Tanaka J, Ishii E, Fukuda M. Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children. PLoS ONE. 2012;7:e42920 pubmed publisher
Kammermeier P. The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency. BMC Pharmacol. 2012;12:6 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Beard R, Reynolds J, Bearden S. Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of ?-catenin in response to homocysteine. Vascul Pharmacol. 2012;56:159-67 pubmed publisher
Ren B, Gu X, Zheng Y, Liu C, Wang D, Sun Y, et al. Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model. Anesthesiology. 2012;116:122-32 pubmed publisher
Chen H, Liao P, Chan M. mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway. J Biomed Sci. 2011;18:19 pubmed publisher
Parri H, Gould T, Crunelli V. Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats. Eur J Neurosci. 2010;32:29-40 pubmed publisher
Lin Y, Chen H, Lin Y, Ko C, Chan M. Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain. J Biomed Sci. 2009;16:94 pubmed publisher
Byrnes K, Stoica B, Riccio A, Pajoohesh Ganji A, Loane D, Faden A. Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents. Ann Neurol. 2009;66:63-74 pubmed publisher
Byrnes K, Stoica B, Loane D, Riccio A, Davis M, Faden A. Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. Glia. 2009;57:550-60 pubmed publisher
Neyman S, Manahan Vaughan D. Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro. Eur J Neurosci. 2008;27:1345-52 pubmed publisher
Kim S, Markham J, Weiler I, Greenough W. Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome. Proc Natl Acad Sci U S A. 2008;105:4429-34 pubmed publisher
Ferre S, Karcz Kubicha M, Hope B, Popoli P, Burgueno J, Gutiérrez M, et al. Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Proc Natl Acad Sci U S A. 2002;99:11940-5 pubmed
product information
master code :
1049
SKU :
1049/10
product name :
CHPG
unit size :
10 mg (also 50 mg)
description :
mGlu5 selective agonist
target :
Group I mGluR Agonists
category :
Small Molecules
purity :
99%
observed molecular weight :
201.61
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CHPG is a selective mGlu5 metabotropic glutamate receptor agonist, completely inactive at mGlu1a receptors expressed in CHO cells. Active in vivo . . Sodium Salt also available.
top caption :
mGlu5 selective agonist
extended description :
mGlu5 selective agonist
chemical name text :
(RS)-2-Chloro-5-hydroxyphenylglycine
formula :
C8H8NO3Cl
formula text :
C8H8NO3Cl
cas num :
170846-74-9
USD :
156 USD
product details :
mGlu5 selective agonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK