product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1047/1
catalog :
1047/1
quantity :
1 mg (also 10 mg, 50 mg)
price :
135 USD
more info or order :
citations: 293
Reference
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Bloomfield M, Louie M. Chronic cadmium exposure decreases the dependency of MCF7 breast cancer cells on ERα. Sci Rep. 2019;9:12135 pubmed publisher
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Rincón Rodriguez R, Mena D, Mena J, Díaz Saldívar P, Guajardo Correa E, Godoy Guzmán C, et al. F-Spondin Is the Signal by Which 2-Methoxyestradiol Induces Apoptosis in the Endometrial Cancer Cell Line Ishikawa. Int J Mol Sci. 2019;20: pubmed publisher
Hosford S, Shee K, Wells J, Traphagen N, Fields J, Hampsch R, et al. Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer. Mol Oncol. 2019;: pubmed publisher
Cortés E, Lachowski D, Rice A, Thorpe S, Robinson B, Yeldag G, et al. Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. Oncogene. 2019;38:2910-2922 pubmed publisher
Cortés E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe S, et al. GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Rep. 2019;20: pubmed publisher
Cortés E, Lachowski D, Robinson B, Sarper M, Teppo J, Thorpe S, et al. Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival. EMBO Rep. 2019;20: pubmed publisher
Rabaglino M, Keller Wood M, Wood C. A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780. Physiol Rep. 2018;6:e13871 pubmed publisher
Du T, Sikora M, Levine K, Tasdemir N, Riggins R, Wendell S, et al. Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer. Breast Cancer Res. 2018;20:106 pubmed publisher
Das B, Dobrowolski C, Luttge B, Valadkhan S, Chomont N, Johnston R, et al. Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir. Proc Natl Acad Sci U S A. 2018;115:E7795-E7804 pubmed publisher
Kaymak A, Sayols S, Papadopoulou T, Richly H. Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance. Oncotarget. 2018;9:28666-28690 pubmed publisher
Ulhaq Z, Kishida M. Brain Aromatase Modulates Serotonergic Neuron by Regulating Serotonin Levels in Zebrafish Embryos and Larvae. Front Endocrinol (Lausanne). 2018;9:230 pubmed publisher
Simões B, Kohler B, Clarke R, Stringer J, Novak Frazer L, Young K, et al. Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors. Ther Adv Med Oncol. 2018;10:1758835918766189 pubmed publisher
Jallow F, Brockman J, Helzer K, Rugowski D, Goffin V, Alarid E, et al. 17?-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes. J Endocr Soc. 2018;2:293-309 pubmed publisher
Gibson D, Collins F, Cousins F, Esnal Zufiaurre A, Saunders P. The impact of 27-hydroxycholesterol on endometrial cancer proliferation. Endocr Relat Cancer. 2018;25:381-391 pubmed publisher
Li Z, Levine K, Bahreini A, Wang P, Chu D, Park B, et al. Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells. Endocrinology. 2018;159:285-296 pubmed publisher
Lou Y, Hu M, Wang Q, Yuan M, Wang N, Le F, et al. Estradiol Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1. Int J Biol Sci. 2017;13:434-448 pubmed publisher
Panza S, Santoro M, De Amicis F, Morelli C, Passarelli V, D Aquila P, et al. Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells. Tumour Biol. 2017;39:1010428317701642 pubmed publisher
Lu J, Jin P, Gao W, Wang D, Sheng J. Estrogen enhances mismatch repair by induction of MLH1 expression via estrogen receptor-β. Oncotarget. 2017;8:38767-38779 pubmed publisher
Stender J, Nwachukwu J, Kastrati I, Kim Y, Strid T, Yakir M, et al. Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells. Mol Cell. 2017;65:1122-1135.e5 pubmed publisher
Zhu Y, Kawaguchi K, Kiyama R. Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors. PLoS ONE. 2017;12:e0171390 pubmed publisher
Wong C, Au C, Tsang S, Lau C, Yao X, Cai Z, et al. Role of inducible nitric oxide synthase in endothelium-independent relaxation to raloxifene in rat aorta. Br J Pharmacol. 2017;174:718-733 pubmed publisher
Mao C, Livezey M, Kim J, Shapiro D. Antiestrogen Resistant Cell Lines Expressing Estrogen Receptor ? Mutations Upregulate the Unfolded Protein Response and are Killed by BHPI. Sci Rep. 2016;6:34753 pubmed publisher
Diep C, Ahrendt H, Lange C. Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes. Steroids. 2016;114:48-58 pubmed publisher
Pastore M, Talwar S, Conley M, Magness R. Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells. Biol Reprod. 2016;94:139 pubmed publisher
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Ciucci A, Zannoni G, Buttarelli M, Lisi L, Travaglia D, Martinelli E, et al. Multiple direct and indirect mechanisms drive estrogen-induced tumor growth in high grade serous ovarian cancers. Oncotarget. 2016;7:8155-71 pubmed publisher
Maselli A, Conti F, Alessandri C, Colasanti T, Barbati C, Vomero M, et al. Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus. Biol Sex Differ. 2016;7:3 pubmed publisher
Peretz J, Pekosz A, Lane A, Klein S. Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors. Am J Physiol Lung Cell Mol Physiol. 2016;310:L415-25 pubmed publisher
Shappell N, Flythe M, Aiken G. The Effects of Steroid Implant and Dietary Soybean Hulls on Estrogenic Activity of Sera of Steers Grazing Toxic Endophyte-Infected Tall Fescue Pasture. Front Vet Sci. 2015;2:30 pubmed publisher
Bains M, Roberts J. Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway. Neurosci Lett. 2016;610:79-85 pubmed publisher
Miyoshi N, Wittner B, Shioda K, Hitora T, Ito T, Ramaswamy S, et al. Nodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulvestrant action and breast cancer prognosis. Oncogenesis. 2015;4:e172 pubmed publisher
Castro J, Araya G, Inostroza P, Hidalgo P, González Ramos R, Sovino H, et al. Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: estradiol regulation. Biol Res. 2015;48:56 pubmed publisher
Xu Y, Morse L, da Silva R, Wang D, Battaglino R. A short report: PAMM, a novel antioxidant protein, induced by oxidative stress. Redox Biol. 2015;6:446-453 pubmed publisher
Simões B, O Brien C, Eyre R, Silva A, Yu L, Sarmiento Castro A, et al. Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity. Cell Rep. 2015;12:1968-77 pubmed publisher
Wardell S, Nelson E, Chao C, Alley H, McDonnell D. Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. Endocr Relat Cancer. 2015;22:713-24 pubmed publisher
Xiong Y, Liu F, Liu D, Huang H, Wei N, Tan L, et al. Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway. Aging Cell. 2015;14:867-77 pubmed publisher
Tozzi A, de Iure A, Tantucci M, Durante V, Quiroga Varela A, Giampà C, et al. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci. 2015;9:192 pubmed publisher
Cook K, Clarke R. Estrogen receptor-α signaling and localization regulates autophagy and unfolded protein response activation in ER+ breast cancer. Receptors Clin Investig. 2014;1: pubmed
Tomita S, Abdalla M, Fujiwara S, Matsumori H, Maehara K, Ohkawa Y, et al. A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation. Nat Commun. 2015;6:6966 pubmed publisher
Wu Y, Shen Y, Kang K, Zhang Y, Ao F, Wan Y, et al. Effects of estrogen on growth and smooth muscle differentiation of vascular wall-resident CD34(+) stem/progenitor cells. Atherosclerosis. 2015;240:453-61 pubmed publisher
Larsen S, Yde C, Laenkholm A, Rasmussen B, Duun Henriksen A, Bak M, et al. Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer. BMC Cancer. 2015;15:239 pubmed publisher
Kim S, Markosyan N, Pepe G, Duffy D. Estrogen promotes luteolysis by redistributing prostaglandin F2α receptors within primate luteal cells. Reproduction. 2015;149:453-64 pubmed publisher
Luzhna L, Lykkesfeldt A, Kovalchuk O. Altered radiation responses of breast cancer cells resistant to hormonal therapy. Oncotarget. 2015;6:1678-94 pubmed
Wang W, Knosp E, Tai G, Zhao Y, Liang Q, Guo Y. Differential effects of estrogen and estrogen receptor antagonist, ICI 182 780, on the expression of calbindin-D9k in rat pituitary prolactinoma GH₃ cells. Int J Clin Exp Pathol. 2014;7:8498-505 pubmed
Zhou Y, Shen J, Xia L, Wang Y. Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling. Cancer Cell Int. 2014;14:540 pubmed publisher
Hole S, Pedersen A, Hansen S, Lundqvist J, Yde C, Lykkesfeldt A. New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane. Int J Oncol. 2015;46:1481-90 pubmed publisher
Segovia Mendoza M, Jurado R, Mir R, Medina L, Prado Garcia H, Garcia Lopez P. Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo study. BMC Cancer. 2015;15:21 pubmed publisher
Albanito L, Lappano R, Madeo A, Chimento A, Prossnitz E, Cappello A, et al. Effects of atrazine on estrogen receptor α- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts. Environ Health Perspect. 2015;123:493-9 pubmed publisher
Harvey C, Chen J, Bagnell C, Uzumcu M. Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro. Reprod Toxicol. 2015;51:72-8 pubmed publisher
Yi J, Do I, Jang J, Kim S, Kim K, Park S, et al. Anti-tumor efficacy of fulvestrant in estrogen receptor positive gastric cancer. Sci Rep. 2014;4:7592 pubmed publisher
Bean J, Hosford S, Symonds L, Owens P, Dillon L, Yang W, et al. The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer. Breast Cancer Res Treat. 2015;149:69-79 pubmed publisher
Alao J, Michlikova S, Dinér P, Grøtli M, Sunnerhagen P. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014;14:853 pubmed publisher
Hu R, Warri A, Jin L, Zwart A, Riggins R, Fang H, et al. NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer. Mol Cell Biol. 2015;35:379-90 pubmed publisher
Gottardo M, Jaita G, Magri M, Zárate S, Moreno Ayala M, Ferraris J, et al. Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis. PLoS ONE. 2014;9:e111548 pubmed publisher
Fan P, Agboke F, Cunliffe H, Ramos P, Jordan V. A molecular model for the mechanism of acquired tamoxifen resistance in breast cancer. Eur J Cancer. 2014;50:2866-76 pubmed publisher
Greaves E, Collins F, Esnal Zufiaurre A, Giakoumelou S, Horne A, Saunders P. Estrogen receptor (ER) agonists differentially regulate neuroangiogenesis in peritoneal endometriosis via the repellent factor SLIT3. Endocrinology. 2014;155:4015-26 pubmed publisher
Oróstica M, Lopez J, Rojas I, Rocco J, Diaz P, Reuquén P, et al. Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism. Reproduction. 2014;148:285-94 pubmed publisher
Liang X, Deng W, Li M, Zhao Z, Wang T, Feng X, et al. Egr1 protein acts downstream of estrogen-leukemia inhibitory factor (LIF)-STAT3 pathway and plays a role during implantation through targeting Wnt4. J Biol Chem. 2014;289:23534-45 pubmed publisher
Kastrati I, Canestrari E, Frasor J. PHLDA1 expression is controlled by an estrogen receptor-NF?B-miR-181 regulatory loop and is essential for formation of ER+ mammospheres. Oncogene. 2015;34:2309-16 pubmed publisher
Giretti M, Montt Guevara M, Cecchi E, Mannella P, Palla G, Spina S, et al. Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton. Front Endocrinol (Lausanne). 2014;5:80 pubmed publisher
Colciago A, Ruscica M, Mornati O, Piccolella M, Montagnani Marelli M, Eberini I, et al. In vitro chronic administration of ERbeta selective ligands and prostate cancer cell growth: hypotheses on the selective role of 3beta-adiol in AR-positive RV1 cells. Biomed Res Int. 2014;2014:801473 pubmed publisher
Myers S, Yang C, Bittner G, Witt K, Tice R, Baird D. Estrogenic and anti-estrogenic activity of off-the-shelf hair and skin care products. J Expo Sci Environ Epidemiol. 2015;25:271-7 pubmed publisher
Kirkegaard T, Yde C, Kveiborg M, Lykkesfeldt A. The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines. Int J Oncol. 2014;45:393-400 pubmed publisher
Adomas A, Grimm S, Malone C, Takaku M, Sims J, Wade P. Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278 pubmed publisher
Seo H, Choi Y, Shim J, Yoo I, Ka H. Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs. Biol Reprod. 2014;90:99 pubmed publisher
Aupperlee M, Zhao Y, Tan Y, Leipprandt J, Bennett J, Haslam S, et al. Epidermal growth factor receptor (EGFR) signaling is a key mediator of hormone-induced leukocyte infiltration in the pubertal female mammary gland. Endocrinology. 2014;155:2301-13 pubmed publisher
Hill B, Muldrew E. Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries. Clin Exp Pharmacol Physiol. 2014;41:430-6 pubmed publisher
Haagenson K, Zhang J, Xu Z, Shekhar M, Wu G. Functional analysis of MKP-1 and MKP-2 in breast cancer tamoxifen sensitivity. Oncotarget. 2014;5:1101-10 pubmed
Nag S, Mokha S. Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates ?2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat. Neuroscience. 2014;267:122-34 pubmed publisher
Yonova I, Osborne C, Morrissette N, Jarvo E. Diaryl and heteroaryl sulfides: synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents. J Org Chem. 2014;79:1947-53 pubmed publisher
Jafaar Z, Litchfield L, Ivanova M, Radde B, Al Rayyan N, Klinge C. β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression. Int J Oncol. 2014;44:1365-75 pubmed publisher
Choi S, Shin H, Song H, Lim H. Suppression of autophagic activation in the mouse uterus by estrogen and progesterone. J Endocrinol. 2014;221:39-50 pubmed publisher
Chen L, Lee W. Estradiol reduces ferrous citrate complex-induced NOS2 up-regulation in cerebral endothelial cells by interfering the nuclear factor kappa B transactivation through an estrogen receptor β-mediated pathway. PLoS ONE. 2013;8:e84320 pubmed publisher
Merenbakh Lamin K, Ben Baruch N, Yeheskel A, Dvir A, Soussan Gutman L, Jeselsohn R, et al. D538G mutation in estrogen receptor-?: A novel mechanism for acquired endocrine resistance in breast cancer. Cancer Res. 2013;73:6856-64 pubmed publisher
Fan P, Agboke F, McDaniel R, Sweeney E, Zou X, Creswell K, et al. Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells. Eur J Cancer. 2014;50:457-68 pubmed publisher
Park J, Kim D, Ahn H, Song Y, Lee Y, Ryu J. Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia. Biomol Ther (Seoul). 2012;20:183-8 pubmed publisher
Johansson H, Sanchez B, Mundt F, Forshed J, Kovács A, Panizza E, et al. Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Nat Commun. 2013;4:2175 pubmed publisher
Smith A, Bosch M, Wagner E, Rønnekleiv O, Kelly M. The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-estradiol. Am J Physiol Endocrinol Metab. 2013;305:E632-40 pubmed publisher
Greaves E, Collins F, Critchley H, Saunders P. ER?-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1. Hum Reprod. 2013;28:2490-501 pubmed publisher
Shim M, Lee Y. Estrogen receptor is activated by korean red ginseng in vitro but not in vivo. J Ginseng Res. 2012;36:169-75 pubmed publisher
Aupperlee M, Leipprandt J, Bennett J, Schwartz R, Haslam S. Amphiregulin mediates progesterone-induced mammary ductal development during puberty. Breast Cancer Res. 2013;15:R44 pubmed publisher
Zhang X, Diaz M, Yee D. Fulvestrant regulates epidermal growth factor (EGF) family ligands to activate EGF receptor (EGFR) signaling in breast cancer cells. Breast Cancer Res Treat. 2013;139:351-60 pubmed publisher
Speroni L, Whitt G, Xylas J, Quinn K, Jondeau Cabaton A, Barnes C, et al. Hormonal regulation of epithelial organization in a three-dimensional breast tissue culture model. Tissue Eng Part C Methods. 2014;20:42-51 pubmed publisher
Morandi A, Martin L, Gao Q, Pancholi S, Mackay A, Robertson D, et al. GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors. Cancer Res. 2013;73:3783-95 pubmed publisher
Giordano G, Tait L, Furlong C, Cole T, Kavanagh T, Costa L. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Free Radic Biol Med. 2013;58:98-108 pubmed publisher
Aida Yasuoka K, Peoples C, Yasuoka H, Hershberger P, Thiel K, Cauley J, et al. Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis. Arthritis Res Ther. 2013;15:R10 pubmed publisher
Varea O, Escoll M, Diez H, Garrido J, Wandosell F. Oestradiol signalling through the Akt-mTORC1-S6K1. Biochim Biophys Acta. 2013;1833:1052-64 pubmed publisher
Lee Y, Kim J, Bae J, Lee J, Kim P, Jang H, et al. Estrogen-like activity of aqueous extract from Agrimonia pilosa Ledeb. in MCF-7 cells. BMC Complement Altern Med. 2012;12:260 pubmed publisher
Camacho Leal M, Pincini A, Tornillo G, Fiorito E, Bisaro B, Di Luca E, et al. p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF. PLoS ONE. 2012;7:e49817 pubmed publisher
Kim H, Kim Y, Ku S, Kim S, Choi Y, Moon S. The effect of estrogen compounds on human embryoid bodies. Reprod Sci. 2013;20:661-9 pubmed publisher
Ruiz M, Rigalli J, Arias A, Villanueva S, Banchio C, Vore M, et al. Induction of hepatic multidrug resistance-associated protein 3 by ethynylestradiol is independent of cholestasis and mediated by estrogen receptor. Drug Metab Dispos. 2013;41:275-80 pubmed publisher
Privette Vinnedge L, Ho S, Wikenheiser Brokamp K, Wells S. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLoS ONE. 2012;7:e46985 pubmed publisher
Teng Y, Manavalan T, Hu C, Medjakovic S, Jungbauer A, Klinge C. Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells. Toxicol Sci. 2013;131:71-83 pubmed publisher
Cruz P, Torres C, Ramírez M, Epuñan M, Valladares L, Sierralta W. Proliferation of human mammary cancer cells exposed to 27-hydroxycholesterol. Exp Ther Med. 2010;1:531-536 pubmed
Sievers C, Shanle E, Bradfield C, Xu W. Differential action of monohydroxylated polycyclic aromatic hydrocarbons with estrogen receptors ? and ?. Toxicol Sci. 2013;132:359-67 pubmed publisher
Mahmoodzadeh S, Pham T, Kuehne A, Fielitz B, Dworatzek E, Kararigas G, et al. 17?-Estradiol-induced interaction of ER? with NPPA regulates gene expression in cardiomyocytes. Cardiovasc Res. 2012;96:411-21 pubmed publisher
Niu K, Zhang Y, Ro J. Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats. Pain. 2012;153:2283-91 pubmed publisher
Wen S, Cao G, Bao T, Cheng L, Li H, Du C, et al. Modulation of ovine SBD-1 expression by 17beta-estradiol in ovine oviduct epithelial cells. BMC Vet Res. 2012;8:143 pubmed publisher
Antoon J, Bratton M, Guillot L, Wadsworth S, Salvo V, Burow M. Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation. Cancer Biol Ther. 2012;13:1026-33 pubmed publisher
Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ER?) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 pubmed publisher
Ikeda Y, Tajima S, Izawa Ishizawa Y, Kihira Y, Ishizawa K, Tomita S, et al. Estrogen regulates hepcidin expression via GPR30-BMP6-dependent signaling in hepatocytes. PLoS ONE. 2012;7:e40465 pubmed publisher
Valera M, Gratacap M, Gourdy P, Lenfant F, Cabou C, Toutain C, et al. Chronic estradiol treatment reduces platelet responses and protects mice from thromboembolism through the hematopoietic estrogen receptor ?. Blood. 2012;120:1703-12 pubmed publisher
Cook K, Shajahan A, Warri A, Jin L, Hilakivi Clarke L, Clarke R. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness. Cancer Res. 2012;72:3337-49 pubmed publisher
Peretz J, Craig Z, Flaws J. Bisphenol A inhibits follicle growth and induces atresia in cultured mouse antral follicles independently of the genomic estrogenic pathway. Biol Reprod. 2012;87:63 pubmed
Cao D, Ji Y, Tang B, Traub R. Estrogen receptor ? activation is antinociceptive in a model of visceral pain in the rat. J Pain. 2012;13:685-94 pubmed publisher
Litchfield L, Riggs K, Hockenberry A, Oliver L, Barnhart K, Cai J, et al. Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor ? transcription in breast cancer cells. PLoS ONE. 2012;7:e38278 pubmed publisher
Zhao G, Nie Y, Lv M, He L, Wang T, Hou Y. ERβ-mediated estradiol enhances epithelial mesenchymal transition of lung adenocarcinoma through increasing transcription of midkine. Mol Endocrinol. 2012;26:1304-15 pubmed publisher
Collins Burow B, Antoon J, Frigo D, Elliott S, Weldon C, Boue S, et al. Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha. J Steroid Biochem Mol Biol. 2012;132:186-93 pubmed publisher
Brion F, Le Page Y, Piccini B, Cardoso O, Tong S, Chung B, et al. Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos. PLoS ONE. 2012;7:e36069 pubmed publisher
Youn J, Nguyen A, Cai H. Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis. Clin Sci (Lond). 2012;123:509-18 pubmed publisher
Bobustuc G, Smith J, Maddipatla S, Jeudy S, Limaye A, Isley B, et al. MGMT inhibition restores ER? functional sensitivity to antiestrogen therapy. Mol Med. 2012;18:913-29 pubmed publisher
Zuloaga K, O Connor D, Handa R, Gonzales R. Estrogen receptor beta dependent attenuation of cytokine-induced cyclooxygenase-2 by androgens in human brain vascular smooth muscle cells and rat mesenteric arteries. Steroids. 2012;77:835-44 pubmed publisher
Richardson T, Yu A, Wen Y, Yang S, Simpkins J. Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts. PLoS ONE. 2012;7:e34600 pubmed publisher
Ropero A, Alonso Magdalena P, Soriano S, Juan Pico P, Roepke T, Kelly M, et al. Insulinotropic effect of the non-steroidal compound STX in pancreatic β-cells. PLoS ONE. 2012;7:e34650 pubmed publisher
Wilk A, Waligórska A, Waligórski P, Ochoa A, Reiss K. Inhibition of ERβ induces resistance to cisplatin by enhancing Rad51-mediated DNA repair in human medulloblastoma cell lines. PLoS ONE. 2012;7:e33867 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Babu P, Si H, Fu Z, Zhen W, Liu D. Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice. J Nutr. 2012;142:724-30 pubmed publisher
Spink B, Bennett J, Lostritto N, Cole J, Spink D. Expression of the aryl hydrocarbon receptor is not required for the proliferation, migration, invasion, or estrogen-dependent tumorigenesis of MCF-7 breast cancer cells. Mol Carcinog. 2013;52:544-54 pubmed publisher
Wang Y, Kuehl Kovarik M. Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons. Brain Res. 2012;1436:81-91 pubmed publisher
González Arenas A, Hansberg Pastor V, Hernández Hernández O, González García T, Henderson Villalpando J, Lemus Hernández D, et al. Estradiol increases cell growth in human astrocytoma cell lines through ER? activation and its interaction with SRC-1 and SRC-3 coactivators. Biochim Biophys Acta. 2012;1823:379-86 pubmed publisher
Ahn H, Yang H, An B, Choi K, Jeung E. Expression and regulation of Enpp2 in rat uterus during the estrous cycle. J Vet Sci. 2011;12:379-85 pubmed
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product information
master code :
1047
SKU :
1047/1
product name :
ICI 182,780
unit size :
1 mg (also 10 mg, 50 mg)
description :
Estrogen receptor antagonist
target :
Estrogen and Related Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
606.77
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
ICI 182,780 is a high affinity estrogen receptor antagonist (IC50 = 0.29 nM), devoid of any partial agonism both in vitro and in vivo . ICI 182,780 is a high affinity agonist at the membrane estrogen receptor GPER. ICI 182,780 inhibits MCF-7 human breast cancer cell growth in vitro and shows antitumor activity in mice models. ICI 182,780 penetrates the blood-brain-barrier and has neuronal functional effects in vivo .
top caption :
Estrogen receptor antagonist
extended description :
Estrogen receptor antagonist
chemical name text :
7 ,17 -[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
formula :
C32H47F5O3S
formula text :
C32H47F5O3S
cas num :
129453-61-8
USD :
135 USD
product details :
Estrogen receptor antagonist
alt names :
Fulvestrant
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK