1041/10 | Tocris Bioscience 1041/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1041/10

catalog :

1041/10

quantity :

10 mg (also 50 mg)

price :

96 USD

more info or order :

Tocris Bioscience product webpage

citations: 20

Reference
Bushart D, Chopra R, Singh V, Murphy G, Wulff H, Shakkottai V. Targeting potassium channels to treat cerebellar ataxia. Ann Clin Transl Neurol. 2018;5:297-314 pubmed publisher
Gamble George J, Baldi R, Halladay L, Kocharian A, Hartley N, Silva C, et al. Cyclooxygenase-2 inhibition reduces stress-induced affective pathology. elife. 2016;5: pubmed publisher
Wells M, Wimmer R, Schmitt L, Feng G, Halassa M. Thalamic reticular impairment underlies attention deficit in Ptchd1(Y/-) mice. Nature. 2016;532:58-63 pubmed publisher
Zundler S, Caioni M, Müller M, Strauch U, Kunst C, Woelfel G. K+ Channel Inhibition Differentially Regulates Migration of Intestinal Epithelial Cells in Inflamed vs. Non-Inflamed Conditions in a PI3K/Akt-Mediated Manner. PLoS ONE. 2016;11:e0147736 pubmed publisher
Rau A, Chappell A, Butler T, Ariwodola O, Weiner J. Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress. J Neurosci. 2015;35:9730-40 pubmed publisher
Cuppoletti J, Chakrabarti J, Tewari K, Malinowska D. Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents. Am J Physiol Cell Physiol. 2014;307:C479-92 pubmed publisher
Roach K, Roach K, Duffy S, Coward W, Feghali Bostwick C, Wulff H, et al. The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis. PLoS ONE. 2013;8:e85244 pubmed publisher
Choi S, Na H, Kim J, Cho S, Suh S. Contradictory Effects of Superoxide and Hydrogen Peroxide on KCa3.1 in Human Endothelial Cells. Korean J Physiol Pharmacol. 2013;17:181-7 pubmed publisher
Benton M, Lewis A, Bant J, Raman I. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol. 2013;109:2528-41 pubmed publisher
Maiz J, Karakossian M, Pakaprot N, Robleto K, Thompson R, Otis T. Prolonging the postcomplex spike pause speeds eyeblink conditioning. Proc Natl Acad Sci U S A. 2012;109:16726-30 pubmed publisher
Cuppoletti J, Chakrabarti J, Tewari K, Malinowska D. Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents. Cell Biochem Biophys. 2013;66:53-63 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Cruse G, Singh S, Duffy S, Doe C, Saunders R, Brightling C, et al. Functional KCa3.1 K+ channels are required for human fibrocyte migration. J Allergy Clin Immunol. 2011;128:1303-1309.e2 pubmed publisher
Lai W, Chen S, Wu H, Guan Y, Liu L, Zeng Y, et al. PRL-3 promotes the proliferation of LoVo cells via the upregulation of KCNN4 channels. Oncol Rep. 2011;26:909-17 pubmed publisher
Haddock R, Grayson T, Morris M, Howitt L, Chadha P, Sandow S. Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms. PLoS ONE. 2011;6:e16423 pubmed publisher
Park S, Kim J, Joo K, Choi S, Choi E, Shin J, et al. Globotriaosylceramide leads to K(Ca)3.1 channel dysfunction: a new insight into endothelial dysfunction in Fabry disease. Cardiovasc Res. 2011;89:290-9 pubmed publisher
Duffy S, Cruse G, Brightling C, Bradding P. Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor. Eur J Immunol. 2007;37:1653-62 pubmed
Kusama N, Kajikuri J, Yamamoto T, Watanabe Y, Suzuki Y, Katsuya H, et al. Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitroglycerine administration. Br J Pharmacol. 2005;146:487-97 pubmed
Banderali U, Klein H, Garneau L, Simoes M, Parent L, Sauve R. New insights on the voltage dependence of the KCa3.1 channel block by internal TBA. J Gen Physiol. 2004;124:333-48 pubmed
Manaves V, Qin W, Bauer A, Rossie S, Kobayashi M, Rane S. Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed. BMC Dermatol. 2004;4:7 pubmed

product information

master code :

1041

SKU :

1041/10

product name :

1-EBIO

unit size :

10 mg (also 50 mg)

description :

Epithelial KCa channel activator

target :

Ca2+-Activated Potassium Channel Activators

category :

Small Molecules

purity :

99%

observed molecular weight :

162.19

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

1-EBIO is an activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.

top caption :

Epithelial KCa channel activator

extended description :

Epithelial KCa channel activator

chemical name text :

1-Ethyl-2-benzimidazolinone

formula :

C9H10N2O

formula text :

C9H10N2O

cas num :

10045-45-1

USD :

96 USD

product details :

Epithelial KCa channel activator

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage