1040/10 | Tocris Bioscience 1040/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1040/10

catalog :

1040/10

quantity :

10 mg (also 50 mg)

price :

221 USD

more info or order :

Tocris Bioscience product webpage

citations: 16

Reference
Hellmer C, Clemons M, Nawy S, Ichinose T. A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina. Physiol Rep. 2018;6:e13885 pubmed publisher
Manookin M, Patterson S, Linehan C. Neural Mechanisms Mediating Motion Sensitivity in Parasol Ganglion Cells of the Primate Retina. Neuron. 2018;97:1327-1340.e4 pubmed publisher
Chaffiol A, Ishii M, Cao Y, Mangel S. Dopamine Regulation of GABAA Receptors Contributes to Light/Dark Modulation of the ON-Cone Bipolar Cell Receptive Field Surround in the Retina. Curr Biol. 2017;27:2600-2609.e4 pubmed publisher
Ichinose T, Hellmer C. Differential signalling and glutamate receptor compositions in the OFF bipolar cell types in the mouse retina. J Physiol. 2016;594:883-94 pubmed publisher
Murphy Baum B, Taylor W. The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina. J Neurosci. 2015;35:13336-50 pubmed publisher
Elgueta C, Vielma A, Palacios A, Schmachtenberg O. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Front Cell Neurosci. 2015;9:6 pubmed publisher
Yan X, Jiang E, Weng H. Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta. J Neuroinflammation. 2015;12:222 pubmed publisher
Vielma A, Agurto A, Valdes J, Palacios A, Schmachtenberg O. Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells. PLoS ONE. 2014;9:e114330 pubmed publisher
Antonelli R, Pizzarelli R, Pedroni A, Fritschy J, Del Sal G, Cherubini E, et al. Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction. Nat Commun. 2014;5:5066 pubmed publisher
Jensen R. Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa. PLoS ONE. 2013;8:e79126 pubmed publisher
Chittajallu R, Pelkey K, McBain C. Neurogliaform cells dynamically regulate somatosensory integration via synapse-specific modulation. Nat Neurosci. 2013;16:13-5 pubmed publisher
Jiang E, Yan X, Weng H. Glial glutamate transporter and glutamine synthetase regulate GABAergic synaptic strength in the spinal dorsal horn. J Neurochem. 2012;121:526-36 pubmed publisher
Olmos Serrano J, Paluszkiewicz S, Martin B, Kaufmann W, Corbin J, Huntsman M. Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. J Neurosci. 2010;30:9929-38 pubmed publisher
Lindstrom S, Azizi N, Weller C, Wilson M. Retinal input to efferent target amacrine cells in the avian retina. Vis Neurosci. 2010;27:103-18 pubmed publisher
Gascon E, Dayer A, Sauvain M, Potter G, Jenny B, De Roo M, et al. GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb. J Neurosci. 2006;26:12956-66 pubmed
Wood M, Murkitt K, Rice S, Testa T, Punia P, Stammers M, et al. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000;131:1050-4 pubmed

product information

master code :

1040

SKU :

1040/10

product name :

TPMPA

unit size :

10 mg (also 50 mg)

description :

Selective GABAA- antagonist

target :

GABAA-rho Receptor Antagonists

category :

Small Molecules

purity :

97%

observed molecular weight :

161.14

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TPMPA is a selective, competitive GABAA- antagonist with only minimal effects on GABAA and GABAB receptors (Kb values are 2.1 u M (antagonist), 320 u M (antagonist) and EC50 ~ 500 u M (weak agonist) respectively). Displays 8-fold selectivity for human recombinant 1 receptors over 2 receptors.

top caption :

Selective GABAA- antagonist

extended description :

Selective GABAA- antagonist

chemical name text :

(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid

formula :

C6H12NO2P

formula text :

C6H12NO2P

cas num :

182485-36-5

USD :

221 USD

product details :

Selective GABAA- antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage