PD 153035 hydrochloride | Tocris Bioscience 1037 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PD 153035 hydrochloride

catalog :

1037

quantity :

10 mg (also 50 mg)

price :

154 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Marshall J, Barnes A, Genever P. Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells. Bioengineering (Basel). 2018;5: pubmed publisher
Lahey K, Ronaghan N, Shang J, Dion S, Desilets A, Leduc R, et al. Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS ONE. 2017;12:e0180259 pubmed publisher
Taylor D, Clark A, Wheeler S, Wells A. Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. Breast Cancer Res Treat. 2014;144:551-60 pubmed publisher
Swanson C, Akama Garren E, Stein E, Petralia J, Ruiz P, Edalati A, et al. Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis. J Immunol. 2012;188:3513-21 pubmed publisher
Xu K, Shu H. EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas. Cancer Res. 2007;67:6121-9 pubmed

product information

brand :

Tocris

master code :

1037

SKU :

1037/10

product name :

PD 153035 hydrochloride

description :

EGFR-kinase inhibitor

target :

EGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

396.67

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

catalog number base :

1037

product keywords :

EGFR-kinase inhibitors inhibits Epidermal Growth Factors Receptors ErbB Her Receptor Tyrosine Kinases RTKs PD153035 hydrochloride AstraZeneca ZM252868 ZM 252868 EGFR 1037,

extended description :

EGFR-kinase inhibitor

chemical name text :

4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride

formula :

C 16 H 14 BrN 3 O 2 .HCl

formula text :

C16H14BrN3O2.HCl

cas num :

183322-45-4

2020 USD :

154

2021 USD :

154 USD

alt names :

ZM 252868

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage