product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
1036/10
catalog :
1036/10
quantity :
10 mg (also 50 mg)
price :
234 USD
more info or order :
citations: 117
Reference
Monticone G, Huang Z, Csibi F, Leit S, Ciccone D, Champhekar A, et al. Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses. Front Immunol. 2022;13:987298 pubmed publisher
De Nuccio C, Bernardo A, Ferrante A, Pepponi R, Martire A, Falchi M, et al. Adenosine A2A receptor stimulation restores cell functions and differentiation in Niemann-Pick type C-like oligodendrocytes. Sci Rep. 2019;9:9782 pubmed publisher
Ryzhov S, May T, Dziodzio J, Emery I, Lucas F, Leclerc A, et al. Number of Circulating CD 73-Expressing Lymphocytes Correlates With Survival After Cardiac Arrest. J Am Heart Assoc. 2019;8:e010874 pubmed publisher
Ng P, McIntosh K, Hargrave G, Ho K, Paul A, Plevin R. Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells. Cell Signal. 2018;51:59-71 pubmed publisher
Palani C, Ramanathapuram L, Lam ubol A, Kurago Z. Toll-like receptor 2 induces adenosine receptor A2a and promotes human squamous carcinoma cell growth via extracellular signal regulated kinases ½. Oncotarget. 2018;9:6814-6829 pubmed publisher
Hirata Y, Furuhashi K, Ishii H, Li H, Pinho S, Ding L, et al. CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine. Cell Stem Cell. 2018;22:445-453.e5 pubmed publisher
Wakisaka N, Miyasaka N, Koide T, Masuda M, Hiraki Kajiyama T, Yoshihara Y. An Adenosine Receptor for Olfaction in Fish. Curr Biol. 2017;27:1437-1447.e4 pubmed publisher
Liu Y, Yang T, Zhao L, Ni Z, Yang N, He F, et al. Activation of Adenosine 2A receptor inhibits neutrophil apoptosis in an autophagy-dependent manner in mice with systemic inflammatory response syndrome. Sci Rep. 2016;6:33614 pubmed publisher
Mediero A, Wilder T, Reddy V, Cheng Q, Tovar N, Coelho P, et al. Ticagrelor regulates osteoblast and osteoclast function and promotes bone formation in vivo via an adenosine-dependent mechanism. FASEB J. 2016;30:3887-3900 pubmed
Caiazzo E, Maione F, Morello S, Lapucci A, Paccosi S, Steckel B, et al. Adenosine signalling mediates the anti-inflammatory effects of the COX-2 inhibitor nimesulide. Biochem Pharmacol. 2016;112:72-81 pubmed publisher
Perez Aso M, Montesinos M, Mediero A, Wilder T, Schafer P, Cronstein B. Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors. Arthritis Res Ther. 2015;17:249 pubmed publisher
Stoddart L, Johnstone E, Wheal A, Goulding J, Robers M, Machleidt T, et al. Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 2015;12:661-663 pubmed publisher
Hegde V, Singh U, Nagarkatti P, Nagarkatti M. Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo. J Immunol. 2015;194:5211-22 pubmed publisher
Jamshad M, Charlton J, Lin Y, Routledge S, Bawa Z, Knowles T, et al. G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent. Biosci Rep. 2015;35: pubmed publisher
Cunha M, Pazini F, Rosa J, Ramos Hryb A, Oliveira Ã, Kaster M, et al. Creatine, similarly to ketamine, affords antidepressant-like effects in the tail suspension test via adenosine A₁ and A2A receptor activation. Purinergic Signal. 2015;11:215-27 pubmed publisher
Oliveira L, Correia A, Cristina Costa A, Guerra Gomes S, Ferreirinha F, Magalhães Cardoso M, et al. Deficits in endogenous adenosine formation by ecto-5'-nucleotidase/CD73 impair neuromuscular transmission and immune competence in experimental autoimmune myasthenia gravis. Mediators Inflamm. 2015;2015:460610 pubmed publisher
Kohno K, Ohashi E, Sano O, Kusano H, Kunikata T, Arai N, et al. Anti-inflammatory effects of adenosine N1-oxide. J Inflamm (Lond). 2015;12:2 pubmed publisher
Amarnath S, Foley J, Farthing D, Gress R, Laurence A, Eckhaus M, et al. Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo. Stem Cells. 2015;33:1200-12 pubmed publisher
Welihinda A, Amento E. Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond). 2014;11:37 pubmed publisher
Sassi Y, Ahles A, Truong D, Baqi Y, Lee S, Husse B, et al. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest. 2014;124:5385-97 pubmed publisher
Tosolini M, Pont F, Bétous D, Ravet E, Ligat L, Lopez F, et al. Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2a Gαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Mol Cell Biol. 2015;35:479-95 pubmed publisher
Persson P, Hansell P, Palm F. Reduced adenosine A2a receptor-mediated efferent arteriolar vasodilation contributes to diabetes-induced glomerular hyperfiltration. Kidney Int. 2015;87:109-15 pubmed publisher
Perígolo Vicente R, Ritt K, Gonçalves de Albuquerque C, Castro Faria Neto H, Paes de Carvalho R, Giestal de Araujo E. IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection. Biochem Biophys Res Commun. 2014;449:477-82 pubmed publisher
Ahsan M, Mehal W. Activation of adenosine receptor A2A increases HSC proliferation and inhibits death and senescence by down-regulation of p53 and Rb. Front Pharmacol. 2014;5:69 pubmed publisher
Ruby C, Vadnie C, Hinton D, Abulseoud O, Walker D, O Connor K, et al. Adenosinergic regulation of striatal clock gene expression and ethanol intake during constant light. Neuropsychopharmacology. 2014;39:2432-40 pubmed publisher
Subramanian M, Kini R, Madasu M, Ohta A, Nowak M, Exley M, et al. Extracellular adenosine controls NKT-cell-dependent hepatitis induction. Eur J Immunol. 2014;44:1119-29 pubmed publisher
Ouyang X, Ghani A, Malik A, Wilder T, COLEGIO O, Flavell R, et al. Adenosine is required for sustained inflammasome activation via the A?A receptor and the HIF-1? pathway. Nat Commun. 2013;4:2909 pubmed publisher
Csóka B, Koscsó B, Töro G, Kókai E, Virag L, Németh Z, et al. A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation. Diabetes. 2014;63:850-66 pubmed publisher
Jeon S, Bak H, Seo J, Han S, Lee S, Han S, et al. Oroxylin A Induces BDNF Expression on Cortical Neurons through Adenosine A2A Receptor Stimulation: A Possible Role in Neuroprotection. Biomol Ther (Seoul). 2012;20:27-35 pubmed publisher
Chiodi V, Mallozzi C, Ferrante A, CHEN J, Lombroso P, Di Stasi A, et al. Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Neuropsychopharmacology. 2014;39:569-78 pubmed publisher
Koscsó B, Csóka B, Kókai E, Németh Z, Pacher P, Virag L, et al. Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol. 2013;94:1309-15 pubmed publisher
Mediavilla Varela M, Luddy K, Noyes D, Khalil F, Neuger A, Soliman H, et al. Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth. Cancer Biol Ther. 2013;14:860-8 pubmed publisher
He W, Mazumder A, Wilder T, Cronstein B. Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J. 2013;27:3446-54 pubmed publisher
Jenabian M, Seddiki N, Yatim A, Carriere M, Hulin A, Younas M, et al. Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection. PLoS Pathog. 2013;9:e1003319 pubmed publisher
Fernández Dueñas V, Gómez Soler M, Morató X, Núñez F, Das A, Kumar T, et al. Dopamine D(2) receptor-mediated modulation of adenosine A(2A) receptor agonist binding within the A(2A)R/D(2)R oligomer framework. Neurochem Int. 2013;63:42-6 pubmed publisher
Hein T, Xu W, Ren Y, Kuo L. Cellular signalling pathways mediating dilation of porcine pial arterioles to adenosine A?A receptor activation. Cardiovasc Res. 2013;99:156-63 pubmed publisher
Nam H, Hinton D, Kang N, Kim T, Lee M, Oliveros A, et al. Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A receptor in the dorsomedial striatum. J Neurosci. 2013;33:4329-38 pubmed publisher
Jastrzebska B, Salom D, Jin H, Cao P, Sun W, Palczewski K, et al. Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans. Methods Enzymol. 2013;520:239-56 pubmed publisher
Lee S, Kim J, Kim J, Jang Y, Kim J, Park Y, et al. Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study. Korean J Anesthesiol. 2012;63:340-5 pubmed publisher
Stoddart L, Vernall A, Denman J, Briddon S, Kellam B, Hill S. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol. 2012;19:1105-15 pubmed publisher
Mandapathil M, Szczepanski M, Harasymczuk M, Ren J, Cheng D, Jackson E, et al. CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma. Oncoimmunology. 2012;1:659-669 pubmed
Fernández Dueñas V, Gómez Soler M, Jacobson K, Kumar S, Fuxe K, Borroto Escuela D, et al. Molecular determinants of A2AR-D2R allosterism: role of the intracellular loop 3 of the D2R. J Neurochem. 2012;123:373-84 pubmed publisher
Moidunny S, Vinet J, Wesseling E, Bijzet J, Shieh C, Van IJzendoorn S, et al. Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity. J Neuroinflammation. 2012;9:198 pubmed
Lindquist B, Shuttleworth C. Adenosine receptor activation is responsible for prolonged depression of synaptic transmission after spreading depolarization in brain slices. Neuroscience. 2012;223:365-76 pubmed publisher
Kinsey G, Huang L, Jaworska K, Khutsishvili K, Becker D, Ye H, et al. Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection. J Am Soc Nephrol. 2012;23:1528-37 pubmed publisher
Suzuki M, Jagger A, Konya C, Shimojima Y, Pryshchep S, Goronzy J, et al. CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells. J Immunol. 2012;189:2118-30 pubmed publisher
Lee Y, Yang Y, Huang C, Kuo T, Lin J, Yang D, et al. When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders?. PLoS ONE. 2012;7:e38865 pubmed publisher
Tozzi A, de Iure A, Marsili V, Romano R, Tantucci M, Di Filippo M, et al. A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. PLoS ONE. 2012;7:e38312 pubmed publisher
Mediero A, Frenkel S, Wilder T, He W, Mazumder A, Cronstein B. Adenosine A2A receptor activation prevents wear particle-induced osteolysis. Sci Transl Med. 2012;4:135ra65 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Gołembiowska K, Dziubina A. The effect of adenosine A(2A) receptor antagonists on hydroxyl radical, dopamine, and glutamate in the striatum of rats with altered function of VMAT2. Neurotox Res. 2012;22:150-7 pubmed publisher
Kucerova L, Broz V, Fleischmannova J, Santruckova E, Sidorov R, Dolezal V, et al. Characterization of the Drosophila adenosine receptor: the effect of adenosine analogs on cAMP signaling in Drosophila cells and their utility for in vivo experiments. J Neurochem. 2012;121:383-95 pubmed publisher
Figueiredo A, Serafim T, Marques da Silva E, Meyer Fernandes J, Afonso L. Leishmania amazonensis impairs DC function by inhibiting CD40 expression via A2B adenosine receptor activation. Eur J Immunol. 2012;42:1203-15 pubmed publisher
Waickman A, Alme A, Senaldi L, Zarek P, Horton M, Powell J. Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor. Cancer Immunol Immunother. 2012;61:917-26 pubmed publisher
Takedachi M, Oohara H, Smith B, Iyama M, Kobashi M, Maeda K, et al. CD73-generated adenosine promotes osteoblast differentiation. J Cell Physiol. 2012;227:2622-31 pubmed publisher
Williams A, Cronstein B. The effect of A(2A) adenosine receptor activation on C-C chemokine receptor 7 expression in human THP1 macrophages during inflammation. Inflammation. 2012;35:614-22 pubmed publisher
Zhukov A, Andrews S, Errey J, Robertson N, Tehan B, Mason J, et al. Biophysical mapping of the adenosine A2A receptor. J Med Chem. 2011;54:4312-23 pubmed publisher
Jin L, Zhang L, Xie K, Ye Y, Feng L. Paeoniflorin suppresses the expression of intercellular adhesion molecule-1 (ICAM-1) in endotoxin-treated human monocytic cells. Br J Pharmacol. 2011;164:694-703 pubmed publisher
Garcia G, Truong L, Chen J, Johnson R, Feng L. Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation. Kidney Int. 2011;80:378-88 pubmed publisher
Kiebala M, Maggirwar S. Ibudilast, a pharmacologic phosphodiesterase inhibitor, prevents human immunodeficiency virus-1 Tat-mediated activation of microglial cells. PLoS ONE. 2011;6:e18633 pubmed publisher
Ruiz García A, Monsalve E, Novellasdemunt L, Navarro Sabate A, Manzano A, Rivero S, et al. Cooperation of adenosine with macrophage Toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene. J Biol Chem. 2011;286:19247-58 pubmed publisher
Riccioni T, Leonardi F, Borsini F. Adenosine A(2A) Receptor Binding Profile of Two Antagonists, ST1535 and KW6002: Consideration on the Presence of Atypical Adenosine A(2A) Binding Sites. Front Psychiatry. 2010;1:22 pubmed publisher
Tozzi A, de Iure A, Di Filippo M, Tantucci M, Costa C, Borsini F, et al. The distinct role of medium spiny neurons and cholinergic interneurons in the D?/A?A receptor interaction in the striatum: implications for Parkinson's disease. J Neurosci. 2011;31:1850-62 pubmed publisher
Wang Z, Che P, Du J, Ha B, Yarema K. Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385. PLoS ONE. 2010;5:e13883 pubmed publisher
Paisansathan C, Xu H, Vetri F, Hernandez M, Pelligrino D. Interactions between adenosine and K+ channel-related pathways in the coupling of somatosensory activation and pial arteriolar dilation. Am J Physiol Heart Circ Physiol. 2010;299:H2009-17 pubmed publisher
Long X, Mokelke E, Neeb Z, Alloosh M, Edwards J, Sturek M. Adenosine receptor regulation of coronary blood flow in Ossabaw miniature swine. J Pharmacol Exp Ther. 2010;335:781-7 pubmed publisher
Gebremedhin D, Weinberger B, Lourim D, Harder D. Adenosine can mediate its actions through generation of reactive oxygen species. J Cereb Blood Flow Metab. 2010;30:1777-90 pubmed publisher
Carlström M, Wilcox C, Welch W. Adenosine A(2) receptors modulate tubuloglomerular feedback. Am J Physiol Renal Physiol. 2010;299:F412-7 pubmed publisher
Gazoni L, Walters D, Unger E, Linden J, Kron I, Laubach V. Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2010;140:440-6 pubmed publisher
Himer L, Csóka B, Selmeczy Z, Koscsó B, Pócza T, Pacher P, et al. Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death. FASEB J. 2010;24:2631-40 pubmed publisher
Bingham T, Fisher E, Parathath S, Reiss A, Chan E, Cronstein B. A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux. J Leukoc Biol. 2010;87:683-90 pubmed publisher
Nowak M, Lynch L, Yue S, Ohta A, Sitkovsky M, Balk S, et al. The A2aR adenosine receptor controls cytokine production in iNKT cells. Eur J Immunol. 2010;40:682-7 pubmed publisher
Mandapathil M, Hilldorfer B, Szczepanski M, Czystowska M, Szajnik M, Ren J, et al. Generation and accumulation of immunosuppressive adenosine by human CD4+CD25highFOXP3+ regulatory T cells. J Biol Chem. 2010;285:7176-86 pubmed publisher
Ohta A, Ohta A, Madasu M, Kini R, Subramanian M, Goel N, et al. A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments. J Immunol. 2009;183:5487-93 pubmed publisher
Clark B, Kurth Nelson Z, Newman E. Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation. J Neurosci. 2009;29:11237-45 pubmed publisher
Yu E, Traylor Z, Davis I. Effect of ventilation pressure on alveolar fluid clearance and beta-agonist responses in mice. Am J Physiol Lung Cell Mol Physiol. 2009;297:L785-93 pubmed publisher
Pugliese A, Traini C, Cipriani S, Gianfriddo M, Mello T, Giovannini M, et al. The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices. Br J Pharmacol. 2009;157:818-30 pubmed publisher
Wilson J, Ross W, Agbai O, Frazier R, Figler R, Rieger J, et al. The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells. J Immunol. 2009;182:4616-23 pubmed publisher
Alam M, Kurtz C, Wilson J, Burnette B, Wiznerowicz E, Ross W, et al. A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence. Mucosal Immunol. 2009;2:232-42 pubmed publisher
Epperson S, Brunton L, Ramirez Sanchez I, Villarreal F. Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts. Am J Physiol Cell Physiol. 2009;296:C1171-7 pubmed publisher
Maeda T, Koos B. Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2009;296:R693-701 pubmed publisher
Singh S, Gras A, Fiez Vandal C, Ruprecht J, Rana R, Martinez M, et al. Large-scale functional expression of WT and truncated human adenosine A2A receptor in Pichia pastoris bioreactor cultures. Microb Cell Fact. 2008;7:28 pubmed publisher
Liou G, Auchampach J, Hillard C, Zhu G, Yousufzai B, Mian S, et al. Mediation of cannabidiol anti-inflammation in the retina by equilibrative nucleoside transporter and A2A adenosine receptor. Invest Ophthalmol Vis Sci. 2008;49:5526-31 pubmed publisher
Csóka B, Himer L, Selmeczy Z, Vizi E, Pacher P, Ledent C, et al. Adenosine A2A receptor activation inhibits T helper 1 and T helper 2 cell development and effector function. FASEB J. 2008;22:3491-9 pubmed publisher
Fernandez P, Trzaska S, Wilder T, Chiriboga L, Blackburn M, Cronstein B, et al. Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine. Am J Pathol. 2008;172:1675-82 pubmed publisher
Nakav S, Chaimovitz C, Sufaro Y, Lewis E, Shaked G, Czeiger D, et al. Anti-inflammatory preconditioning by agonists of adenosine A1 receptor. PLoS ONE. 2008;3:e2107 pubmed publisher
Bertarelli D, Diekmann M, Hayallah A, Rüsing D, Iqbal J, Preiss B, et al. Characterization of human and rodent native and recombinant adenosine A(2B) receptors by radioligand binding studies. Purinergic Signal. 2006;2:559-71 pubmed publisher
Garcia G, Truong L, Li P, Zhang P, Du J, Chen J, et al. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. FASEB J. 2008;22:445-54 pubmed
Shi Y, Liu X, Gebremedhin D, Falck J, Harder D, Koehler R. Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex. J Cereb Blood Flow Metab. 2008;28:111-25 pubmed
Lappas C, Day Y, Marshall M, Engelhard V, Linden J. Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. J Exp Med. 2006;203:2639-48 pubmed
Ramanathan M, Pinhal Enfield G, Hao I, Leibovich S. Synergistic up-regulation of vascular endothelial growth factor (VEGF) expression in macrophages by adenosine A2A receptor agonists and endotoxin involves transcriptional regulation via the hypoxia response element in the VEGF promoter. Mol Biol Cell. 2007;18:14-23 pubmed
Ge Z, Peart J, Kreckler L, Wan T, Jacobson M, Gross G, et al. Cl-IB-MECA [2-chloro-N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide] reduces ischemia/reperfusion injury in mice by activating the A3 adenosine receptor. J Pharmacol Exp Ther. 2006;319:1200-10 pubmed
Chan E, Montesinos M, Fernandez P, Desai A, Delano D, Yee H, et al. Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Br J Pharmacol. 2006;148:1144-55 pubmed
Zhang N, Yang D, Dong H, Chen Q, Dimitrova D, Rogers T, et al. Adenosine A2a receptors induce heterologous desensitization of chemokine receptors. Blood. 2006;108:38-44 pubmed
Murphree L, Sullivan G, Marshall M, Linden J. Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction. Biochem J. 2005;391:575-80 pubmed
Newman E. Calcium increases in retinal glial cells evoked by light-induced neuronal activity. J Neurosci. 2005;25:5502-10 pubmed
Erdmann A, Gao Z, Jung U, Foley J, Borenstein T, Jacobson K, et al. Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo. Blood. 2005;105:4707-14 pubmed
Jacobson K, Ohno M, Duong H, Kim S, Tchilibon S, Cesnek M, et al. A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists. Chem Biol. 2005;12:237-47 pubmed
Kornerup K, Page C, Moffatt J. Pharmacological characterisation of the adenosine receptor mediating increased ion transport in the mouse isolated trachea and the effect of allergen challenge. Br J Pharmacol. 2005;144:1011-6 pubmed
Fresco P, Diniz C, Goncalves J. Facilitation of noradrenaline release by activation of adenosine A(2A) receptors triggers both phospholipase C and adenylate cyclase pathways in rat tail artery. Cardiovasc Res. 2004;63:739-46 pubmed
Germack R, Dickenson J. Characterization of ERK1/2 signalling pathways induced by adenosine receptor subtypes in newborn rat cardiomyocytes. Br J Pharmacol. 2004;141:329-39 pubmed
Yip L, Kwok Y. Role of adenosine A2A receptor in the regulation of gastric somatostatin release. J Pharmacol Exp Ther. 2004;309:804-15 pubmed
Wen L, Knowles A. Extracellular ATP and adenosine induce cell apoptosis of human hepatoma Li-7A cells via the A3 adenosine receptor. Br J Pharmacol. 2003;140:1009-18 pubmed
Dall Igna O, Porciuncula L, Souza D, Cunha R, Lara D, Dall lgna O. Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity. Br J Pharmacol. 2003;138:1207-9 pubmed
Nishi A, Liu F, Matsuyama S, Hamada M, Higashi H, Nairn A, et al. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling. Proc Natl Acad Sci U S A. 2003;100:1322-7 pubmed
Hirsh J, Silinsky E. Inhibition of spontaneous acetylcholine secretion by 2-chloroadenosine as revealed by a protein kinase inhibitor at the mouse neuromuscular junction. Br J Pharmacol. 2002;135:1897-902 pubmed
Koshiba M, Kosaka H, Nakazawa T, Hayashi N, Saura R, Kitamura N, et al. 2-Chloroadenosine but not adenosine induces apoptosis in rheumatoid fibroblasts independently of cell surface adenosine receptor signalling. Br J Pharmacol. 2002;135:1477-86 pubmed
de Brito M, Canto A, Correia J, Cunha R, Marques M. Adenosine A(2A) receptors in portal hypertension: their role in the abnormal response to adenosine of the cranial mesenteric artery in rabbits. Br J Pharmacol. 2002;135:1324-30 pubmed
Nieri P, Martinotti E, Calderone V, Breschi M. Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NO. Br J Pharmacol. 2001;134:745-52 pubmed
Avila M, Stone R, Civan M. A(1)-, A(2A)- and A(3)-subtype adenosine receptors modulate intraocular pressure in the mouse. Br J Pharmacol. 2001;134:241-5 pubmed
. British Pharmacological Society Meeting. 18-21 December 2000, University of Birmingham. Abstracts. Br J Pharmacol. 2001;133 Suppl:1P-277P pubmed
Lee F, Chao M. Activation of Trk neurotrophin receptors in the absence of neurotrophins. Proc Natl Acad Sci U S A. 2001;98:3555-60 pubmed
Anderson R, Visser S, Ramafi G, Theron A. Accelerated resequestration of cytosolic calcium and suppression of the pro-inflammatory activities of human neutrophils by CGS 21680 in vitro. Br J Pharmacol. 2000;130:717-24 pubmed
Haynes J. A(2A) adenosine receptor mediated potassium channel activation in rat epididymal smooth muscle. Br J Pharmacol. 2000;130:685-91 pubmed
Latini S, Bordoni F, Corradetti R, Pepeu G, Pedata F. Effect of A2A adenosine receptor stimulation and antagonism on synaptic depression induced by in vitro ischaemia in rat hippocampal slices. Br J Pharmacol. 1999;128:1035-44 pubmed
Hernandez M, Barahona M, Bustamante S, Garcia Sacristan A, Orensanz L. A2B adenosine receptors mediate relaxation of the pig intravesical ureter: adenosine modulation of non adrenergic non cholinergic excitatory neurotransmission. Br J Pharmacol. 1999;126:969-78 pubmed
Guibert C, Loirand G, Vigne P, Savineau J, Pacaud P. Dependence of P2-nucleotide receptor agonist-mediated endothelium-independent relaxation on ectonucleotidase activity and A2A-receptors in rat portal vein. Br J Pharmacol. 1998;123:1732-40 pubmed
product information
master code :
1036
SKU :
1036/10
product name :
ZM 241385
unit size :
10 mg (also 50 mg)
description :
Potent and highly selective A2A antagonist
target :
Adenosine A2a Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
337.34
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
ZM 241385 is a potent and highly selective A2A adenosine antagonist, with a pA2 of 9.02 for A2A receptors in guinea pig cardiac vasculature and fold selectivities of 1000, 91 and 500,000 over A1, A2B and A3 sites respectively. Active in vivo . ZM 241385 suppresses the ERK1/2 pathway in human squamous carcinoma cells.
top caption :
Potent and highly selective A2A antagonist
extended description :
Potent and highly selective A2A antagonist
chemical name text :
4-(2-[7-Amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol
formula :
C16H15N7O2
formula text :
C16H15N7O2
cas num :
139180-30-6
USD :
234 USD
product details :
Potent and highly selective A2A antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK