product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
1034/10
catalog :
1034/10
quantity :
10 mg (also 50 mg)
price :
200 USD
more info or order :
citations: 9
Reference
Hou B, Fu Y, Weng C, Liu W, Zhao C, Yin Z. Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats. Front Cell Neurosci. 2017;11:98 pubmed publisher
Chen C, Fichna J, Laudon M, Storr M. Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain. World J Gastroenterol. 2014;20:1298-304 pubmed publisher
Faria J, Kinote A, Ignacio Souza L, de Araújo T, Razolli D, Doneda D, et al. Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats. Am J Physiol Endocrinol Metab. 2013;305:E230-42 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Tunstall R, Shukla P, GRAZUL BILSKA A, Sun C, O Rourke S. MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. J Pharmacol Exp Ther. 2011;336:127-33 pubmed publisher
Jones D, Hallyburton I, Stojanovski L, Read K, Frearson J, Fairlamb A. Identification of a ?-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol. 2010;80:1478-86 pubmed publisher
Zhao W, Zhang M, Miao Y, Yang X, Wang Z. Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells. J Physiol. 2010;588:2605-19 pubmed publisher
Danilova N, Krupnik V, Sugden D, Zhdanova I. Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development. FASEB J. 2004;18:751-3 pubmed
Sjöblom M, Jedstedt G, Flemstrom G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest. 2001;108:625-33 pubmed
image
image 1 :
Tocris Bioscience 1034/10 image 1
Cat.No. 1034 - 4-P-PDOT C19H21NO CAS No. 620170-78-7
product information
master code :
1034
SKU :
1034/10
product name :
4-P-PDOT
unit size :
10 mg (also 50 mg)
description :
MT2 antagonist
target :
Melatonin (MT) Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
279.38
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
4-P-PDOT is a melatonin receptor antagonist, 300-fold selective for the MT2 (vs MT1) subtype.
top caption :
MT2 antagonist
extended description :
MT2 antagonist
chemical name text :
cis-4-Phenyl-2-propionamidotetralin
formula :
C19H21NO
formula text :
C19H21NO
cas num :
620170-78-7
USD :
200 USD
product details :
MT2 antagonist
alt names :
AH 024
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK