product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1032/10
catalog :
1032/10
quantity :
10 mg (also 50 mg)
price :
230 USD
more info or order :
citations: 11
Reference
Zhou M, Sun F, Xu C, Chen H, Qiao H, Cai X, et al. Modulation of Kalirin-7 expression by hippocampal CA1 5-HT1B receptors in spatial memory consolidation. Behav Brain Res. 2019;356:148-155 pubmed publisher
Medrihan L, Sagi Y, Inde Z, Krupa O, Daniels C, Peyrache A, et al. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron. 2017;95:564-576.e4 pubmed publisher
Hirono M, Nagao S, Yanagawa Y, Konishi S. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology. 2017;118:79-89 pubmed publisher
Majeed Z, Abdeljaber E, Soveland R, Cornwell K, Bankemper A, Koch F, et al. Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast. 2016;2016:7291438 pubmed publisher
Watts S, Darios E, Seitz B, Thompson J. 5-HT is a potent relaxant in rat superior mesenteric veins. Pharmacol Res Perspect. 2015;3:e00103 pubmed publisher
Tung S, Hardy A, Wheeler M, Belsham D. Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor. Endocrinology. 2012;153:4862-73 pubmed
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Guo J, Rainnie D. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience. 2010;165:1390-401 pubmed publisher
Watakabe A, Komatsu Y, Sadakane O, Shimegi S, Takahata T, Higo N, et al. Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Cereb Cortex. 2009;19:1915-28 pubmed publisher
Heisler L, Jobst E, Sutton G, Zhou L, Borok E, Thornton Jones Z, et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006;51:239-49 pubmed
Rau K, Birdsall E, Volz T, Riordan J, Baucum A, Adair B, et al. Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake. J Pharmacol Exp Ther. 2006;318:676-82 pubmed
product information
master code :
1032
SKU :
1032/10
product name :
CP 93129 dihydrochloride
unit size :
10 mg (also 50 mg)
description :
5-HT1B agonist
target :
5-HT1B Receptor Agonists
category :
Small Molecules
observed molecular weight :
288.18
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CP 93129 dihydrochloride is a potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.
top caption :
5-HT1B agonist
extended description :
5-HT1B agonist
chemical name text :
1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
formula :
C12H13N3O.2HCl
formula text :
C12H13N3O.2HCl
cas num :
879089-64-2
USD :
230 USD
product details :
5-HT1B agonist
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK