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company name :
Tocris Bioscience
product type :
chemical
product name :
1029/5
catalog :
1029/5
quantity :
5 mg (also 25 mg)
price :
127 USD
more info or order :
citations: 32
Reference
Garton D, Ross S, Maldonado Hernández R, Quick M, Lasalde Dominicci J, Lizardi Ortiz J. Amphetamine enantiomers inhibit homomeric α7 nicotinic receptor through a competitive mechanism and within the intoxication levels in humans. Neuropharmacology. 2019;144:172-183 pubmed publisher
Lozovaya N, Eftekhari S, Cloarec R, Gouty Colomer L, Dufour A, Riffault B, et al. GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease. Nat Commun. 2018;9:1422 pubmed publisher
Muñoz B, Fritz B, Yin F, Atwood B. Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum. Nat Commun. 2018;9:1318 pubmed publisher
Assous M, Kaminer J, Shah F, Garg A, Koos T, Tepper J. Differential processing of thalamic information via distinct striatal interneuron circuits. Nat Commun. 2017;8:15860 pubmed publisher
Herman A, Ortiz Guzman J, Kochukov M, Herman I, Quast K, Patel J, et al. A cholinergic basal forebrain feeding circuit modulates appetite suppression. Nature. 2016;538:253-256 pubmed publisher
Zhang J, Zhang L, Sun X, Yang Y, Kong L, Lu C, et al. Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment Ameliorate Acetaminophen-Induced Liver Injury in Mice via Central Cholinergic System Regulation. J Pharmacol Exp Ther. 2016;359:374-382 pubmed
Tang B, Luo D, Yang J, Xu X, Zhu B, Wang X, et al. Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex. Sci Rep. 2015;5:14099 pubmed publisher
Dannenberg H, Pabst M, Braganza O, Schoch S, Niediek J, Bayraktar M, et al. Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks. J Neurosci. 2015;35:8394-410 pubmed publisher
Saunders A, Granger A, Sabatini B. Corelease of acetylcholine and GABA from cholinergic forebrain neurons. elife. 2015;4: pubmed publisher
Pinnock F, Bosch D, Brown T, Simons N, Yeomans J, DeOliveira C, et al. Nicotine receptors mediating sensorimotor gating and its enhancement by systemic nicotine. Front Behav Neurosci. 2015;9:30 pubmed publisher
Elgueta C, Vielma A, Palacios A, Schmachtenberg O. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Front Cell Neurosci. 2015;9:6 pubmed publisher
Kiss T, Krajcs N, Pirger Z, Hernádi L. Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS ONE. 2014;9:e109538 pubmed publisher
Brown J, Wonnacott S. Sazetidine-A Activates and Desensitizes Native ?7 Nicotinic Acetylcholine Receptors. Neurochem Res. 2015;40:2047-54 pubmed publisher
Mazloom R, Eftekhari G, Rahimi Balaei M, Khori V, Hajizadeh S, Dehpour A, et al. The role of α7 nicotinic acetylcholine receptor in modulation of heart rate dynamics in endotoxemic rats. PLoS ONE. 2013;8:e82251 pubmed publisher
Kim T, Kim S, Lee S. Stimulation of the ?7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation. J Infect Dis. 2014;209:1668-77 pubmed publisher
Nemethova A, Michel K, Gomez Pinilla P, Boeckxstaens G, Schemann M. Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the ?2 nicotinic acetylcholine receptor. PLoS ONE. 2013;8:e79264 pubmed publisher
Hogenkamp D, Ford Hutchinson T, Li W, Whittemore E, Yoshimura R, Tran M, et al. Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors. J Med Chem. 2013;56:8352-65 pubmed publisher
Brown K, Perry H, Lau J, Jones D, Pulliam J, Thornhill B, et al. Nicotine induces the up-regulation of the ?7-nicotinic receptor (?7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway. J Biol Chem. 2013;288:33049-59 pubmed publisher
Callahan P, Hutchings E, Kille N, Chapman J, Terry A. Positive allosteric modulator of ?7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates. Neuropharmacology. 2013;67:201-12 pubmed publisher
Leao R, Mikulovic S, Leao K, Munguba H, Gezelius H, Enjin A, et al. OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat Neurosci. 2012;15:1524-30 pubmed publisher
Yamauchi J, Gomez K, Grimster N, Dufouil M, Nemecz A, Fotsing J, et al. Synthesis of selective agonists for the ?7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates. Mol Pharmacol. 2012;82:687-99 pubmed
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Grimster N, Stump B, Fotsing J, Weide T, Talley T, Yamauchi J, et al. Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template. J Am Chem Soc. 2012;134:6732-40 pubmed publisher
Northrop N, Smith L, Yamamoto B, Eyerman D. Regulation of glutamate release by ?7 nicotinic receptors: differential role in methamphetamine-induced damage to dopaminergic and serotonergic terminals. J Pharmacol Exp Ther. 2011;336:900-7 pubmed publisher
Lecca S, Melis M, Luchicchi A, Ennas M, Castelli M, Muntoni A, et al. Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain dopamine cells. Neuropsychopharmacology. 2011;36:589-602 pubmed publisher
Collins T, Millar N. Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator. Mol Pharmacol. 2010;78:198-204 pubmed publisher
Li Y, LaCroix C, Freeling J. Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. Auton Neurosci. 2010;154:14-9 pubmed publisher
Huang C, Hsu K. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 2010;20:982-96 pubmed publisher
Li Y, LaCroix C, Freeling J. Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. Neurosci Lett. 2009;462:20-3 pubmed publisher
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Hansen S, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y. Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J. 2005;24:3635-46 pubmed
Beckel J, Kanai A, Lee S, de Groat W, Birder L. Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells. Am J Physiol Renal Physiol. 2006;290:F103-10 pubmed
product information
master code :
1029
SKU :
1029/5
product name :
Methyllycaconitine citrate
unit size :
5 mg (also 25 mg)
description :
Selective 7 neuronal nAChR antagonist
target :
Nicotinic (a7) Receptor Antagonists
category :
Small Molecules
purity :
95%
observed molecular weight :
874.93
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Methyllycaconitine citrate is a potent antagonist for 7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with 4 2 and 6 2 receptors at concentrations 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo .
top caption :
Selective 7 neuronal nAChR antagonist
extended description :
Selective 7 neuronal nAChR antagonist
chemical name text :
[1 ,4(S),6 ,14 ,16 ]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate
formula :
C37H50N2O10.C6H8O7
formula text :
C37H50N2O10.C6H8O7
cas num :
351344-10-0
USD :
127 USD
product details :
Selective 7 neuronal nAChR antagonist
alt names :
MLA
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK