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company name :
Tocris Bioscience
product type :
chemical
product name :
1028/10
catalog :
1028/10
quantity :
10 mg (also 50 mg)
price :
226 USD
more info or order :
citations: 30
Reference
Cai Y, Ford C. Dopamine Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of Dopamine and Glutamate. Cell Rep. 2018;25:3148-3157.e3 pubmed publisher
Liao S, Ruiz Y, Gulzar H, Yelskaya Z, Ait Taouit L, Houssou M, et al. Osteosarcoma cell proliferation and survival requires mGluR5 receptor activity and is blocked by Riluzole. PLoS ONE. 2017;12:e0171256 pubmed publisher
Astorga G, Bao J, Marty A, Augustine G, Franconville R, Jalil A, et al. An excitatory GABA loop operating in vivo. Front Cell Neurosci. 2015;9:275 pubmed publisher
Zhong P, Liu Y, Hu Y, Wang T, Zhao Y, Liu Q. BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. J Neurosci. 2015;35:4469-81 pubmed publisher
Oh W, Parajuli L, Zito K. Heterosynaptic structural plasticity on local dendritic segments of hippocampal CA1 neurons. Cell Rep. 2015;10:162-9 pubmed publisher
Kubota H, Nagao S, Obata K, Hirono M. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS ONE. 2014;9:e106316 pubmed publisher
Oh W, Hill T, Zito K. Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening. Proc Natl Acad Sci U S A. 2013;110:E305-12 pubmed publisher
Cozzoli D, Courson J, Caruana A, Miller B, Greentree D, Thompson A, et al. Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. Alcohol Clin Exp Res. 2012;36:1623-33 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Zheng N, Raman I. Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents. J Neurosci. 2011;31:10283-92 pubmed publisher
Tappe Theodor A, Fu Y, Kuner R, Neugebauer V. Homer1a signaling in the amygdala counteracts pain-related synaptic plasticity, mGluR1 function and pain behaviors. Mol Pain. 2011;7:38 pubmed publisher
Tronson N, Guzman Y, Guedea A, Huh K, Gao C, Schwarz M, et al. Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear. Biol Psychiatry. 2010;68:1007-15 pubmed publisher
Jackson C, Welch H, Bellamy T. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. PLoS ONE. 2010;5:e11962 pubmed publisher
Patel J, Witkovsky P, Avshalumov M, Rice M. Mobilization of calcium from intracellular stores facilitates somatodendritic dopamine release. J Neurosci. 2009;29:6568-79 pubmed publisher
Gibson H, Edwards J, Page R, Van Hook M, Kauer J. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron. 2008;57:746-59 pubmed publisher
Shin J, Kim Y, Linden D. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. Proc Natl Acad Sci U S A. 2008;105:746-50 pubmed publisher
Duguid I, Pankratov Y, Moss G, Smart T. Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation. J Neurosci. 2007;27:12464-74 pubmed
Kirschstein T, Bauer M, Müller L, Rüschenschmidt C, Reitze M, Becker A, et al. Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus. J Neurosci. 2007;27:7696-704 pubmed
Bloodgood B, Sabatini B. Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines. Neuron. 2007;53:249-60 pubmed
De Saint Jan D, Westbrook G. Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb. J Neurosci. 2007;27:132-40 pubmed
El Kouhen O, Lehto S, Pan J, Chang R, Baker S, Zhong C, et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 2006;149:761-74 pubmed
Jiang Q, Yan Z, Feng J. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J Neurosci. 2006;26:4318-28 pubmed
Jong Y, Kumar V, Kingston A, Romano C, O Malley K. Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand. J Biol Chem. 2005;280:30469-80 pubmed
Calo L, Bruno V, Spinsanti P, Molinari G, Korkhov V, Esposito Z, et al. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons. J Neurosci. 2005;25:2245-54 pubmed
Hashimotodani Y, Ohno Shosaku T, Tsubokawa H, Ogata H, Emoto K, Maejima T, et al. Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal. Neuron. 2005;45:257-68 pubmed
Melis M, Perra S, Muntoni A, Pillolla G, Lutz B, Marsicano G, et al. Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons. J Neurosci. 2004;24:10707-15 pubmed
Kawasaki Y, Kohno T, Zhuang Z, Brenner G, Wang H, Van Der Meer C, et al. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci. 2004;24:8310-21 pubmed
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Marino M, Williams D, O Brien J, Valenti O, McDonald T, Clements M, et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc Natl Acad Sci U S A. 2003;100:13668-73 pubmed
Kitano J, Nishida M, Itsukaichi Y, Minami I, Ogawa M, Hirano T, et al. Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel. J Biol Chem. 2003;278:25101-8 pubmed
product information
master code :
1028
SKU :
1028/10
product name :
CPCCOEt
unit size :
10 mg (also 50 mg)
description :
Selective non-competitive mGlu1 antagonist
target :
Group I mGluR Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
247.25
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CPCCOEt is a hmGlu1 subtype-selective non-competitive antagonist (IC50 = 6.5 u M). Has no agonist or antagonist activity at hmGlu2, 4a, 5a, 7b, 8a or ionotropic receptors at concentrations of up to 100 u M.
top caption :
Selective non-competitive mGlu1 antagonist
extended description :
Selective non-competitive mGlu1 antagonist
chemical name text :
7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester
formula :
C13H13NO4
formula text :
C13H13NO4
cas num :
179067-99-3
USD :
226 USD
product details :
Selective non-competitive mGlu1 antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK