product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1028/10
catalog :
1028/10
quantity :
10 mg (also 50 mg)
price :
226 USD
more info or order :
citations: 30
Reference |
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Duguid I, Pankratov Y, Moss G, Smart T. Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation. J Neurosci. 2007;27:12464-74 pubmed
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Kirschstein T, Bauer M, Müller L, Rüschenschmidt C, Reitze M, Becker A, et al. Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus. J Neurosci. 2007;27:7696-704 pubmed
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Bloodgood B, Sabatini B. Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines. Neuron. 2007;53:249-60 pubmed
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De Saint Jan D, Westbrook G. Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb. J Neurosci. 2007;27:132-40 pubmed
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El Kouhen O, Lehto S, Pan J, Chang R, Baker S, Zhong C, et al. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist. Br J Pharmacol. 2006;149:761-74 pubmed
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Jiang Q, Yan Z, Feng J. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J Neurosci. 2006;26:4318-28 pubmed
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Jong Y, Kumar V, Kingston A, Romano C, O Malley K. Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand. J Biol Chem. 2005;280:30469-80 pubmed
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Calo L, Bruno V, Spinsanti P, Molinari G, Korkhov V, Esposito Z, et al. Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons. J Neurosci. 2005;25:2245-54 pubmed
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Hashimotodani Y, Ohno Shosaku T, Tsubokawa H, Ogata H, Emoto K, Maejima T, et al. Phospholipase Cbeta serves as a coincidence detector through its Ca2+ dependency for triggering retrograde endocannabinoid signal. Neuron. 2005;45:257-68 pubmed
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Melis M, Perra S, Muntoni A, Pillolla G, Lutz B, Marsicano G, et al. Prefrontal cortex stimulation induces 2-arachidonoyl-glycerol-mediated suppression of excitation in dopamine neurons. J Neurosci. 2004;24:10707-15 pubmed
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Kawasaki Y, Kohno T, Zhuang Z, Brenner G, Wang H, Van Der Meer C, et al. Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization. J Neurosci. 2004;24:8310-21 pubmed
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Wu M, Hajszan T, Xu C, Leranth C, Alreja M. Group I metabotropic glutamate receptor activation produces a direct excitation of identified septohippocampal cholinergic neurons. J Neurophysiol. 2004;92:1216-25 pubmed
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Marino M, Williams D, O Brien J, Valenti O, McDonald T, Clements M, et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc Natl Acad Sci U S A. 2003;100:13668-73 pubmed
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Kitano J, Nishida M, Itsukaichi Y, Minami I, Ogawa M, Hirano T, et al. Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel. J Biol Chem. 2003;278:25101-8 pubmed
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product information
master code :
1028
SKU :
1028/10
product name :
CPCCOEt
unit size :
10 mg (also 50 mg)
description :
Selective non-competitive mGlu1 antagonist
target :
Group I mGluR Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
247.25
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CPCCOEt is a hmGlu1 subtype-selective non-competitive antagonist (IC50 = 6.5 u M). Has no agonist or antagonist activity at hmGlu2, 4a, 5a, 7b, 8a or ionotropic receptors at concentrations of up to 100 u M.
top caption :
Selective non-competitive mGlu1 antagonist
extended description :
Selective non-competitive mGlu1 antagonist
chemical name text :
7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester
formula :
C13H13NO4
formula text :
C13H13NO4
cas num :
179067-99-3
USD :
226 USD
product details :
Selective non-competitive mGlu1 antagonist
storage :
Store at RT
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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