product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PHCCC
catalog :
1027
quantity :
10 mg (also 50 mg)
price :
181 USD
more info or order :
citations: 8
Reference
Volpi C, Mondanelli G, Pallotta M, Vacca C, Iacono A, Gargaro M, et al. Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells. Neuropharmacology. 2016;102:59-71 pubmed publisher
Spampinato S, Merlo S, Chisari M, Nicoletti F, Sortino M. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes. Front Cell Neurosci. 2014;8:462 pubmed publisher
Jones C, Engers D, Thompson A, Field J, Blobaum A, Lindsley S, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate recepto. J Med Chem. 2011;54:7639-47 pubmed publisher
Broadstock M, Austin P, Betts M, Duty S. Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata. Br J Pharmacol. 2012;165:1034-45 pubmed publisher
Foong J, Bornstein J. mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum. Front Neurosci. 2009;3:46 pubmed publisher
Niswender C, Johnson K, Weaver C, Jones C, Xiang Z, Luo Q, et al. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol. 2008;74:1345-58 pubmed publisher
Hemstapat K, de Paulis T, Chen Y, Brady A, Grover V, Alagille D, et al. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol Pharmacol. 2006;70:616-26 pubmed
Collard C, Park K, Montalto M, Alapati S, Buras J, Stahl G, et al. Neutrophil-derived glutamate regulates vascular endothelial barrier function. J Biol Chem. 2002;277:14801-11 pubmed
product information
brand :
Tocris
master code :
1027
SKU :
1027/10
product name :
PHCCC
description :
Potent group I mGlu antagonist
target :
Group I mGluR Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
294.31
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Group I metabotropic glutamate receptor antagonist (IC50 ~ 3 u M); 67 times more potent than (S)-4-carboxyphenylglycine (Cat. No. 0323). Also a positive allosteric modulator for mGlu4a; potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro . Displays antiParkinsonian effects in rats in vivo .
catalog number base :
1027
product keywords :
Potent group I mGlur antagonists Group Receptors mGlu1 mGlu5 Glutamate Metabotropic mGlu4 Glutamate (Metabotropic) Group I Receptors 1027,
extended description :
Potent group I mGlu antagonist
chemical name text :
N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide
formula :
C 17 H 14 N 2 O 3
formula text :
C17H14N2O3
cas num :
179068-02-1
2020 USD :
175
2021 USD :
181 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK