product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1027/10
catalog :
1027/10
quantity :
10 mg (also 50 mg)
price :
203 USD
more info or order :
citations: 9
Reference |
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Jones C, Engers D, Thompson A, Field J, Blobaum A, Lindsley S, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate recepto. J Med Chem. 2011;54:7639-47 pubmed publisher
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Hemstapat K, de Paulis T, Chen Y, Brady A, Grover V, Alagille D, et al. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol Pharmacol. 2006;70:616-26 pubmed
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Collard C, Park K, Montalto M, Alapati S, Buras J, Stahl G, et al. Neutrophil-derived glutamate regulates vascular endothelial barrier function. J Biol Chem. 2002;277:14801-11 pubmed
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image
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Cat.No. 1027 - PHCCC C17H14N2O3 CAS No. 179068-02-1
product information
master code :
1027
SKU :
1027/10
product name :
PHCCC
unit size :
10 mg (also 50 mg)
description :
Potent group I mGlu antagonist
target :
Group I mGluR Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
294.31
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
PHCCC is a group I metabotropic glutamate receptor antagonist (IC50 ~ 3 u M); 67 times more potent than (S)-4-carboxyphenylglycine (Cat. No. 0323). Also a positive allosteric modulator for mGlu4a; potentiates L-AP4 -mediated inhibition of striatopallidal synaptic transmission in vitro . Displays antiParkinsonian effects in rats in vivo .
top caption :
Potent group I mGlu antagonist
extended description :
Potent group I mGlu antagonist
chemical name text :
N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide
formula :
C17H14N2O3
formula text :
C17H14N2O3
cas num :
179068-02-1
USD :
203 USD
product details :
Potent group I mGlu antagonist
storage :
Store at RT
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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