product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
1024/10
catalog :
1024/10
quantity :
10 mg (also 50 mg)
price :
295 USD
more info or order :
citations: 18
Reference
Cruz J, Hupper N, Wilson L, Concannon J, Wang Y, Oberhauser B, et al. Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy. J Biol Chem. 2018;293:11837-11849 pubmed publisher
Lavine J, Farnoodian M, Wang S, Darjatmoko S, Wright L, Gamm D, et al. ?2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci. 2017;58:299-308 pubmed publisher
Ardestani P, Evans A, Yi B, Nguyen T, Coutellier L, Shamloo M. Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist. Neuropharmacology. 2017;116:371-386 pubmed publisher
Creed S, Le C, Hassan M, Pon C, Albold S, Chan K, et al. β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion. Breast Cancer Res. 2015;17:145 pubmed publisher
Weiterer S, Kohlen T, Veit F, Sachs L, Uhle F, Lichtenstern C, et al. Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium. PLoS ONE. 2015;10:e0143163 pubmed publisher
Littmann T, Göttle M, Reinartz M, Kälble S, Wainer I, Ozawa T, et al. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. J Pharmacol Exp Ther. 2015;355:183-90 pubmed publisher
Gherbi K, Briddon S, Hill S. Detection of the secondary, low-affinity ?1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP. Br J Pharmacol. 2014;171:5431-45 pubmed publisher
Li X, Nooh M, Bahouth S. Role of AKAP79/150 protein in ?1-adrenergic receptor trafficking and signaling in mammalian cells. J Biol Chem. 2013;288:33797-812 pubmed publisher
Mistry S, Baker J, Fischer P, Hill S, Gardiner S, Kellam B. Synthesis and in vitro and in vivo characterization of highly ?1-selective ?-adrenoceptor partial agonists. J Med Chem. 2013;56:3852-65 pubmed publisher
Lavine J, Sang Y, Wang S, Ip M, Sheibani N. Attenuation of choroidal neovascularization by ?(2)-adrenoreceptor antagonism. JAMA Ophthalmol. 2013;131:376-82 pubmed publisher
Hott S, Gomes F, Fabri D, Reis D, Crestani C, Correa F, et al. Both ?1- and ?1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear. Br J Pharmacol. 2012;167:207-21 pubmed publisher
Rieg A, Rossaint R, Uhlig S, Martin C. Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices. PLoS ONE. 2011;6:e29698 pubmed publisher
Rankovic V, Landgraf P, Kanyshkova T, Ehling P, Meuth S, Kreutz M, et al. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via ?-adrenergic signaling in thalamocortical relay neurons. PLoS ONE. 2011;6:e27474 pubmed publisher
Cheng G, Kasiganesan H, Baicu C, Wallenborn J, Kuppuswamy D, Cooper G. Cytoskeletal role in protection of the failing heart by ?-adrenergic blockade. Am J Physiol Heart Circ Physiol. 2012;302:H675-87 pubmed publisher
Sucharov C, Dockstader K, Nunley K, McKinsey T, Bristow M. ?-Adrenergic receptor stimulation and activation of protein kinase A protect against ?1-adrenergic-mediated phosphorylation of protein kinase D and histone deacetylase 5. J Card Fail. 2011;17:592-600 pubmed publisher
Lemke T, Welling A, Christel C, Blaich A, Bernhard D, Lenhardt P, et al. Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice. J Biol Chem. 2008;283:34738-44 pubmed publisher
Crestani C, Alves F, Resstel L, Correa F. Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats. Br J Pharmacol. 2008;153:583-90 pubmed
Jane wit D, Altuntas C, Johnson J, Yong S, Wickley P, Clark P, et al. Beta 1-adrenergic receptor autoantibodies mediate dilated cardiomyopathy by agonistically inducing cardiomyocyte apoptosis. Circulation. 2007;116:399-410 pubmed
product information
master code :
1024
SKU :
1024/10
product name :
CGP 20712 dihydrochloride
unit size :
10 mg (also 50 mg)
description :
Highly potent and selective 1 antagonist
target :
Adrenergic beta-1 Receptor Antagonists
category :
Small Molecules
purity :
96%
observed molecular weight :
567.39
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
CGP 20712 dihydrochloride is a highly selective and potent 1-adrenoceptor antagonist (IC50 = 0.7 nM). Displays 10,000-fold selectivity over 2-adrenoceptors.
top caption :
Highly potent and selective 1 antagonist
extended description :
Highly potent and selective 1 antagonist
chemical name text :
1-[2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]-2-propanol dihydrochloride
formula :
C23H25F3N4O5.2HCl
formula text :
C23H25F3N4O5.2HCl
cas num :
1216905-73-5
USD :
295 USD
product details :
Highly potent and selective 1 antagonist
storage :
Desiccate at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK