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company name :
Tocris Bioscience
product type :
chemical
product name :
1014/100
catalog :
1014/100
quantity :
100 mg
price :
156 USD
more info or order :
citations: 33
Reference
He Z, Yin Y, Xi K, Xing Z, Cao J, Liu T, et al. Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice. Cell Rep. 2020;33:108343 pubmed publisher
Li K, He M, Ye W, Simms J, Gill M, Xiang X, et al. TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. elife. 2019;8: pubmed publisher
Spoljaric I, Spoljaric A, Mavrovic M, Seja P, Puskarjov M, Kaila K. KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice. Cell Rep. 2019;26:1073-1081.e3 pubmed publisher
Purkey A, Woolfrey K, Crosby K, Stich D, Chick W, Aoto J, et al. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018;25:974-987.e4 pubmed publisher
Ferrarese L, Jouhanneau J, Remme M, Kremkow J, Katona G, Rozsa B, et al. Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo. Cell Rep. 2018;24:3455-3465.e5 pubmed publisher
Acuña M, Yevenes G, Ralvenius W, Benke D, Di Lio A, Lara C, et al. Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain. J Clin Invest. 2016;126:2547-60 pubmed publisher
McGee T, Bats C, Farrant M, Cull Candy S. Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci. 2015;35:16171-9 pubmed publisher
Xue R, Gaffaney J, Chapman E. Structural elements that underlie Doc2β function during asynchronous synaptic transmission. Proc Natl Acad Sci U S A. 2015;112:E4316-25 pubmed publisher
Lench A, Robson E, Jones R. Differential Effects of D-Cycloserine and ACBC at NMDA Receptors in the Rat Entorhinal Cortex Are Related to Efficacy at the Co-Agonist Binding Site. PLoS ONE. 2015;10:e0133548 pubmed publisher
Ahn J, Kang S, Ahn S. Characteristics of K(+) Outward Currents in the Cochlear Outer Hair Cells of Circling Mice within the First Postnatal Week. Korean J Physiol Pharmacol. 2015;19:383-8 pubmed publisher
Sametsky E, Turner J, Larsen D, Ling L, Caspary D. Enhanced GABAA-Mediated Tonic Inhibition in Auditory Thalamus of Rats with Behavioral Evidence of Tinnitus. J Neurosci. 2015;35:9369-80 pubmed publisher
Puranam R, He X, Yao L, Le T, Jang W, Rehder C, et al. Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus. J Neurosci. 2015;35:8866-81 pubmed publisher
Chen H, Chesler M. Autocrine boost of NMDAR current in hippocampal CA1 pyramidal neurons by a PMCA-dependent, perisynaptic, extracellular pH shift. J Neurosci. 2015;35:873-7 pubmed publisher
Dale E, Zhang H, Leiser S, Xiao Y, Lu D, Yang C, et al. Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. J Psychopharmacol. 2014;28:891-902 pubmed publisher
Chuhma N, Mingote S, Moore H, Rayport S. Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling. Neuron. 2014;81:901-12 pubmed publisher
Gaffaney J, Xue R, Chapman E. Mutations that disrupt Ca²?-binding activity endow Doc2? with novel functional properties during synaptic transmission. Mol Biol Cell. 2014;25:481-94 pubmed publisher
He S, Bausch S. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis. Neuropharmacology. 2014;77:379-86 pubmed publisher
Wu W, Bryant D, Dorsa D, Adelman J, Maylie J. Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses. J Neurosci. 2013;33:16158-69 pubmed publisher
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Toyoda H, Zhao M, Ulzhöfer B, Wu L, Xu H, Seeburg P, et al. Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex. Mol Pain. 2009;5:46 pubmed publisher
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image
image 1 :
Tocris Bioscience 1014/100 image 1
Cat.No. 1014 - QX 314 bromide C16H27N2OBr CAS No. 24003-58-5
product information
master code :
1014
SKU :
1014/100
product name :
QX 314 bromide
unit size :
100 mg
description :
Na+ channel blocker
target :
Voltage-gated Sodium Channel Blockers
category :
Small Molecules
purity :
99%
observed molecular weight :
343.31
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
QX 314 bromide is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels. Intracellular QX 314 bromide also inhibits calcium currents in hippocampal CA1 pyramidal neurons.
top caption :
Na+ channel blocker
extended description :
Na+ channel blocker
chemical name text :
N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
formula :
C16H27N2OBr
formula text :
C16H27N2OBr
cas num :
24003-58-5
USD :
156 USD
product details :
Na+ channel blocker
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK