product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
BMY 7378 dihydrochloride
catalog :
1006
quantity :
10 mg (also 50 mg)
price :
71 USD
more info or order :
citations: 6
Reference
Gadgaard C, Jensen A. Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2020;175:113870 pubmed publisher
Assad Kahn S, Costa S, Gholamin S, Nitta R, Dubois L, Fève M, et al. The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med. 2016;8:511-26 pubmed publisher
Grisanti L, Woster A, Dahlman J, Sauter E, Combs C, Porter J. ?1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages. J Pharmacol Exp Ther. 2011;338:648-57 pubmed publisher
Lee M, Ting K, Adams S, Brew B, Chung R, Guillemin G. Characterisation of the expression of NMDA receptors in human astrocytes. PLoS ONE. 2010;5:e14123 pubmed publisher
Song Z, Gomes D, Stevens W, Sladek C. Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxytocin release by ATP and phenylephrine. Am J Physiol Regul Integr Comp Physiol. 2010;299:R1529-37 pubmed publisher
Atkins N, Mitchell J, Romanova E, Morgan D, Cominski T, Ecker J, et al. Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits. PLoS ONE. 2010;5:e12612 pubmed publisher
product information
brand :
Tocris
master code :
1006
SKU :
1006/10
product name :
BMY 7378 dihydrochloride
description :
Selective 1D antagonist
target :
Adrenergic alpha-1 Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
observed molecular weight :
458.42
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
5-HT1A partial agonist and high affinity 1D adrenoceptor antagonist (Ki values are 2, 800 and 600 nM at cloned rat 1D, rat 1A and hamster 1B receptors, respectively).
catalog number base :
1006
product keywords :
Selective 1D-adrenoceptor alpha1D-adrenoceptor a1d-adrenoceptor 1d-adrenergic alpha1d-adrenergic a1d-adrenergic antagonist 5-HT1A partial agonists Receptors Serotonin BMY7378 dihydrochloride Adrenergic Alpha-1 Receptors 5-HT1A Receptors 1006,
extended description :
Selective 1D antagonist
chemical name text :
8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
formula :
C 22 H 31 N 3 O 3 .2HCl
formula text :
C22H31N3O3.2HCl
cas num :
21102-95-4
2020 USD :
69
2021 USD :
71 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK