BMY 7378 dihydrochloride | Tocris Bioscience 1006/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BMY 7378 dihydrochloride

catalog :

1006/10

quantity :

10 mg (also 50 mg)

price :

83 USD

citations: 6

Reference
Gadgaard C, Jensen A. Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2020;175:113870 pubmed publisher
Assad Kahn S, Costa S, Gholamin S, Nitta R, Dubois L, FÃ¨ve M, et al. The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCÎ´-dependent inhibition of the AKT pathway. EMBO Mol Med. 2016;8:511-26 pubmed publisher
Grisanti L, Woster A, Dahlman J, Sauter E, Combs C, Porter J. ?1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages. J Pharmacol Exp Ther. 2011;338:648-57 pubmed publisher
Lee M, Ting K, Adams S, Brew B, Chung R, Guillemin G. Characterisation of the expression of NMDA receptors in human astrocytes. PLoS ONE. 2010;5:e14123 pubmed publisher
Song Z, Gomes D, Stevens W, Sladek C. Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxytocin release by ATP and phenylephrine. Am J Physiol Regul Integr Comp Physiol. 2010;299:R1529-37 pubmed publisher
Atkins N, Mitchell J, Romanova E, Morgan D, Cominski T, Ecker J, et al. Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits. PLoS ONE. 2010;5:e12612 pubmed publisher

product information

brand :

Tocris

master code :

1006

SKU :

1006/10

product name :

BMY 7378 dihydrochloride

description :

Selective 1D antagonist

target :

Adrenergic alpha-1 Receptor Antagonists

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

observed molecular weight :

458.42

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BMY 7378 dihydrochloride is a 5-HT1A partial agonist and high affinity 1D adrenoceptor antagonist (Ki values are 2, 800 and 600 nM at cloned rat 1D, rat 1A and hamster 1B receptors, respectively).

extended description :

Selective 1D antagonist

chemical name text :

8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride

formula :

C 22 H 31 N 3 O 3 .2HCl

formula text :

C22H31N3O3.2HCl

cas num :

21102-95-4

USD :

USD 2023 :

83 USD

product details :

Selective 1D antagonist

storage :

Store at RT