product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1004/10
catalog :
1004/10
quantity :
10 mg
price :
199 USD
more info or order :
citations: 4
Reference
Dolma S, Selvadurai H, Lan X, Lee L, Kushida M, Voisin V, et al. Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 2016;29:859-873 pubmed publisher
Root D, Hoffman A, Good C, Zhang S, Gigante E, Lupica C, et al. Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. J Neurosci. 2015;35:3460-9 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Bastianetto S, Danik M, Mennicken F, Williams S, Quirion R. Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation. BMC Neurosci. 2006;7:28 pubmed
product information
master code :
1004
SKU :
1004/10
product name :
L-741,742 hydrochloride
unit size :
10 mg
description :
Highly selective D4 antagonist
target :
Dopamine D4 Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
417.38
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
L-741,742 hydrochloride is a potent and highly selective D4 dopamine receptor antagonist, with Ki values of 1700, 770 and 3.5 nM at cloned human D2, D3 and D4 receptors.
top caption :
Highly selective D4 antagonist
extended description :
Highly selective D4 antagonist
chemical name text :
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole hydrochloride
formula :
C23H25N2ClO.HCl
formula text :
C23H25N2ClO.HCl
cas num :
874882-93-6
USD :
199 USD
product details :
Highly selective D4 antagonist
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK