product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
L-741,626
catalog :
1003
quantity :
10 mg (also 50 mg)
price :
136 USD
more info or order :
citations: 10
Reference
Lin C, Lai H, Chen H, Siew J, Hsiao C, Chang H, et al. Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors. Transl Psychiatry. 2019;9:209 pubmed publisher
Wang L, Lee G, Kuei C, Yao X, Harrington A, Bonaventure P, et al. GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact. Front Neurosci. 2019;13:281 pubmed publisher
Zhang Y, Reynolds J, Cragg S. Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine Modulation. Neuron. 2018;98:918-925.e3 pubmed publisher
Xiao L, Priest M, Nasenbeny J, Lu T, Kozorovitskiy Y. Biased Oxytocinergic Modulation of Midbrain Dopamine Systems. Neuron. 2017;95:368-384.e5 pubmed publisher
Newton C, Wood M, Strange P. Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors. PLoS ONE. 2016;11:e0158808 pubmed publisher
Wang J, Cao Y, Li Q, Yang Y, Jin M, Chen D, et al. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy. 2015;11:2057-2073 pubmed publisher
Billes S, Simonds S, Cowley M. Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism. Mol Metab. 2012;1:86-93 pubmed publisher
Belinsky G, Sirois C, Rich M, Short S, Moore A, Gilbert S, et al. Dopamine receptors in human embryonic stem cell neurodifferentiation. Stem Cells Dev. 2013;22:1522-40 pubmed publisher
Dacks A, Riffell J, MARTIN J, Gage S, Nighorn A. Olfactory modulation by dopamine in the context of aversive learning. J Neurophysiol. 2012;108:539-50 pubmed publisher
Yang S, Proks P, Ashcroft F, Rupnik M. Inhibition of ATP-sensitive potassium channels by haloperidol. Br J Pharmacol. 2004;143:960-7 pubmed
product information
brand :
Tocris
master code :
1003
SKU :
1003/10
product name :
L-741,626
description :
High affinity D2 antagonist
target :
Dopamine D2 Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
98%
observed molecular weight :
340.85
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
A potent D2 dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D2, D3 and D4 receptors respectively. Centrally active following systemic administration in vivo .
catalog number base :
1003
product keywords :
High affinity D2 antagonists Dopamine Receptors dopaminergic L741742 D2 Receptors 1003,
extended description :
High affinity D2 antagonist
chemical name text :
3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole
formula :
C 20 H 21 ClN 2 O
formula text :
C20H21ClN2O
cas num :
81226-60-0
2020 USD :
130
2021 USD :
136 USD
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK