1003/10 | Tocris Bioscience 1003/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

1003/10

catalog :

1003/10

quantity :

10 mg (also 50 mg)

price :

177 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Lin C, Lai H, Chen H, Siew J, Hsiao C, Chang H, et al. Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D2 and adenosine A2A receptors. Transl Psychiatry. 2019;9:209 pubmed publisher
Wang L, Lee G, Kuei C, Yao X, Harrington A, Bonaventure P, et al. GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact. Front Neurosci. 2019;13:281 pubmed publisher
Zhang Y, Reynolds J, Cragg S. Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine Modulation. Neuron. 2018;98:918-925.e3 pubmed publisher
Xiao L, Priest M, Nasenbeny J, Lu T, Kozorovitskiy Y. Biased Oxytocinergic Modulation of Midbrain Dopamine Systems. Neuron. 2017;95:368-384.e5 pubmed publisher
Newton C, Wood M, Strange P. Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors. PLoS ONE. 2016;11:e0158808 pubmed publisher
Wang J, Cao Y, Li Q, Yang Y, Jin M, Chen D, et al. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Autophagy. 2015;11:2057-2073 pubmed publisher
O Sullivan D, Green L, Stone S, Zareie P, Kharkrang M, Fong D, et al. Treatment with the antipsychotic agent, risperidone, reduces disease severity in experimental autoimmune encephalomyelitis. PLoS ONE. 2014;9:e104430 pubmed publisher
Billes S, Simonds S, Cowley M. Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism. Mol Metab. 2012;1:86-93 pubmed publisher
Belinsky G, Sirois C, Rich M, Short S, Moore A, Gilbert S, et al. Dopamine receptors in human embryonic stem cell neurodifferentiation. Stem Cells Dev. 2013;22:1522-40 pubmed publisher
Dacks A, Riffell J, MARTIN J, Gage S, Nighorn A. Olfactory modulation by dopamine in the context of aversive learning. J Neurophysiol. 2012;108:539-50 pubmed publisher
Yang S, Proks P, Ashcroft F, Rupnik M. Inhibition of ATP-sensitive potassium channels by haloperidol. Br J Pharmacol. 2004;143:960-7 pubmed

product information

master code :

1003

SKU :

1003/10

product name :

L-741,626

unit size :

10 mg (also 50 mg)

description :

High affinity D2 antagonist

target :

Dopamine D2 Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

340.85

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

L-741,626 is a potent D2 dopamine receptor selective antagonist, with affinities of 2.4, 100 and 220 nM for D2, D3 and D4 receptors respectively. Centrally active following systemic administration in vivo .

top caption :

High affinity D2 antagonist

extended description :

High affinity D2 antagonist

chemical name text :

3-[[4-(4-Chlorophenyl)-4-hydroxypiperidin-l-yl]methyl-1H-indole

formula :

C20H21ClN2O

formula text :

C20H21ClN2O

cas num :

81226-60-0

USD :

177 USD

product details :

High affinity D2 antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage