product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1002/10
catalog :
1002/10
quantity :
10 mg (also 50 mg)
price :
191 USD
more info or order :
citations: 14
Reference
Sharma R, George A, Nimmagadda M, Ortolan D, Karla B, Qureshy Z, et al. Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model. Nat Commun. 2021;12:7293 pubmed publisher
Matsui A, Alvarez V. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep. 2018;23:3852-3863 pubmed publisher
Dai H, Jackson C, Davis G, Blakely R, McMahon D. Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model. J Neurodev Disord. 2017;9:38 pubmed publisher
Guo F, Zhao J, Zhao D, Wang J, Wang X, Feng Z, et al. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice. Aging Cell. 2017;16:1323-1333 pubmed publisher
Camini F, da Silva Caetano C, Almeida L, da Costa Guerra J, de Mello Silva B, de Queiroz Silva S, et al. Oxidative stress in Mayaro virus infection. Virus Res. 2017;236:1-8 pubmed publisher
Picton L, Sillar K. Mechanisms underlying the endogenous dopaminergic inhibition of spinal locomotor circuit function in Xenopus tadpoles. Sci Rep. 2016;6:35749 pubmed publisher
Jensen R. Effects of Dopamine D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas. PLoS ONE. 2015;10:e0146154 pubmed publisher
Chen K, Deng K, Wang X, Wang Z, Zheng S, Ren H, et al. Activation of D4 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Hypertension. 2015;65:153-60 pubmed publisher
Steullet P, Cabungcal J, Cuénod M, Do K. Fast oscillatory activity in the anterior cingulate cortex: dopaminergic modulation and effect of perineuronal net loss. Front Cell Neurosci. 2014;8:244 pubmed publisher
Suárez Boomgaard D, Gago B, Valderrama Carvajal A, Roales Buján R, Van Craenenbroeck K, Duchou J, et al. Dopamine D? receptor counteracts morphine-induced changes in µ opioid receptor signaling in the striosomes of the rat caudate putamen. Int J Mol Sci. 2014;15:1481-98 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Herwerth M, Jensen V, Novak M, Konopka W, Hvalby O, Köhr G. D4 dopamine receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1. Cereb Cortex. 2012;22:1786-98 pubmed publisher
Okada Y, Sakai H, Kohiki E, Suga E, Yanagisawa Y, Tanaka K, et al. A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein. J Cereb Blood Flow Metab. 2005;25:794-806 pubmed
Basso A, Gallagher K, Bratcher N, Brioni J, Moreland R, Hsieh G, et al. Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test. Neuropsychopharmacology. 2005;30:1257-68 pubmed
product information
master code :
1002
SKU :
1002/10
product name :
L-745,870 trihydrochloride
unit size :
10 mg (also 50 mg)
description :
Highly selective D4 antagonist
target :
Dopamine D4 Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
436.21
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
L-745,870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and 1000-fold selectivity over 5-HT2, D1 and D5 receptors.
top caption :
Highly selective D4 antagonist
extended description :
Highly selective D4 antagonist
chemical name text :
3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
formula :
C18H19N4Cl.3HCl
formula text :
C18H19N4Cl.3HCl
cas num :
866021-03-6
USD :
191 USD
product details :
Highly selective D4 antagonist
storage :
Desiccate at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK