product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
1002/10
catalog :
1002/10
quantity :
10 mg (also 50 mg)
price :
191 USD
more info or order :
citations: 14
Reference |
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Dai H, Jackson C, Davis G, Blakely R, McMahon D. Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model. J Neurodev Disord. 2017;9:38 pubmed publisher
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Okada Y, Sakai H, Kohiki E, Suga E, Yanagisawa Y, Tanaka K, et al. A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein. J Cereb Blood Flow Metab. 2005;25:794-806 pubmed
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Basso A, Gallagher K, Bratcher N, Brioni J, Moreland R, Hsieh G, et al. Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test. Neuropsychopharmacology. 2005;30:1257-68 pubmed
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product information
master code :
1002
SKU :
1002/10
product name :
L-745,870 trihydrochloride
unit size :
10 mg (also 50 mg)
description :
Highly selective D4 antagonist
target :
Dopamine D4 Receptor Antagonists
category :
Small Molecules
purity :
99%
observed molecular weight :
436.21
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
L-745,870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist; L-745,870 has Ki values of 0.51, 2300 and 960 nM for D4, D3 and D2 subtypes respectively and 1000-fold selectivity over 5-HT2, D1 and D5 receptors.
top caption :
Highly selective D4 antagonist
extended description :
Highly selective D4 antagonist
chemical name text :
3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
formula :
C18H19N4Cl.3HCl
formula text :
C18H19N4Cl.3HCl
cas num :
866021-03-6
USD :
191 USD
product details :
Highly selective D4 antagonist
storage :
Desiccate at +4░C
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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