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company name :
Tocris Bioscience
product type :
chemical
product name :
1000/10
catalog :
1000/10
quantity :
10 mg (also 50 mg)
price :
219 USD
more info or order :
citations: 58
Reference
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Fan J, Stemkowski P, Gandini M, Black S, Zhang Z, Souza I, et al. Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice. Front Cell Neurosci. 2016;10:74 pubmed publisher
Kashyap M, Yoshimura N, Smith P, Chancellor M, Tyagi P. Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation. Bladder (San Franc). 2015;2: pubmed
Merino B, Quesada I, Hernández Cascales J. Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. PLoS ONE. 2015;10:e0132884 pubmed publisher
Asteriti S, Grillner S, Cangiano L. A Cambrian origin for vertebrate rods. elife. 2015;4: pubmed publisher
Ferreira A, Yousuf H, Dalton S, Sheets P. Highly differentiated cellular and circuit properties of infralimbic pyramidal neurons projecting to the periaqueductal gray and amygdala. Front Cell Neurosci. 2015;9:161 pubmed publisher
Ohno Y, Shimizu S, Tatara A, Imaoku T, Ishii T, Sasa M, et al. Hcn1 is a tremorgenic genetic component in a rat model of essential tremor. PLoS ONE. 2015;10:e0123529 pubmed publisher
Williams S, Hablitz J. Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih. Front Cell Neurosci. 2015;9:89 pubmed publisher
Calejo A, Jorgačevski J, Rituper B, Guček A, Pereira P, Santos M, et al. Hyperpolarization-activated cyclic nucleotide-gated channels and cAMP-dependent modulation of exocytosis in cultured rat lactotrophs. J Neurosci. 2014;34:15638-47 pubmed publisher
Dragicevic E, Poetschke C, Duda J, Schlaudraff F, Lammel S, Schiemann J, et al. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain. 2014;137:2287-302 pubmed publisher
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Zhang C, Tonsfeldt K, Qiu J, Bosch M, Kobayashi K, Steiner R, et al. Molecular mechanisms that drive estradiol-dependent burst firing of Kiss1 neurons in the rostral periventricular preoptic area. Am J Physiol Endocrinol Metab. 2013;305:E1384-97 pubmed publisher
Yi F, Zhang X, Yang C, Li B. Contribution of dopamine d1/5 receptor modulation of post-spike/burst afterhyperpolarization to enhance neuronal excitability of layer v pyramidal neurons in prepubertal rat prefrontal cortex. PLoS ONE. 2013;8:e71880 pubmed publisher
Cilz N, Kurada L, Hu B, Lei S. Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K⁺, and T-type Ca²⁺ channels. Cereb Cortex. 2014;24:3195-208 pubmed publisher
Zhang Z, Cordeiro Matos S, Jego S, Adamantidis A, Séguéla P. Norepinephrine drives persistent activity in prefrontal cortex via synergistic ?1 and ?2 adrenoceptors. PLoS ONE. 2013;8:e66122 pubmed publisher
Abbas S, Hamade K, Yang E, Nawy S, Smith R, Pettit D. Directional summation in non-direction selective retinal ganglion cells. PLoS Comput Biol. 2013;9:e1002969 pubmed publisher
Masi A, Narducci R, Landucci E, Moroni F, Mannaioni G. MPP(+) -dependent inhibition of Ih reduces spontaneous activity and enhances EPSP summation in nigral dopamine neurons. Br J Pharmacol. 2013;169:130-42 pubmed publisher
Boehlen A, Henneberger C, Heinemann U, Erchova I. Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells. J Neurophysiol. 2013;109:445-63 pubmed publisher
Saito Y, Inoue T, Zhu G, Kimura N, Okada M, Nishimura M, et al. Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and A? generation in Alzheimer's disease. Mol Neurodegener. 2012;7:50 pubmed publisher
Patel S, Salvi J, O Maoiléidigh D, Hudspeth A. Frequency-selective exocytosis by ribbon synapses of hair cells in the bullfrog's amphibian papilla. J Neurosci. 2012;32:13433-8 pubmed
Maiz J, Karakossian M, Pakaprot N, Robleto K, Thompson R, Otis T. Prolonging the postcomplex spike pause speeds eyeblink conditioning. Proc Natl Acad Sci U S A. 2012;109:16726-30 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Angelo K, Margrie T. Population diversity and function of hyperpolarization-activated current in olfactory bulb mitral cells. Sci Rep. 2011;1:50 pubmed publisher
Few A, Nanou E, Watari H, Sullivan J, Scheuer T, Catterall W. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release. Proc Natl Acad Sci U S A. 2012;109:E452-60 pubmed publisher
Ma J, Guo L, Fiene S, Anson B, Thomson J, Kamp T, et al. High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am J Physiol Heart Circ Physiol. 2011;301:H2006-17 pubmed publisher
Brummett C, Hong E, Janda A, Amodeo F, Lydic R. Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current. Anesthesiology. 2011;115:836-43 pubmed publisher
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Chu H, Gu Q, Jin G, Hu G, Zhen X. Electrophysiological effects of SKF83959 on hippocampal CA1 pyramidal neurons: potential mechanisms for the drug's neuroprotective effects. PLoS ONE. 2010;5: pubmed publisher
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Jung S, Bullis J, Lau I, Jones T, Warner L, Poolos N. Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling. J Neurosci. 2010;30:6678-88 pubmed publisher
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Chen X, Shu S, Schwartz L, Sun C, Kapur J, Bayliss D. Homeostatic regulation of synaptic excitability: tonic GABA(A) receptor currents replace I(h) in cortical pyramidal neurons of HCN1 knock-out mice. J Neurosci. 2010;30:2611-22 pubmed publisher
Zhang H, Parker J, Shepherd N, Creazzo T. Developmental expression of a functional TASK-1 2P domain K+ channel in embryonic chick heart. J Biomed Sci. 2009;16:104 pubmed publisher
Ballo A, Bucher D. Complex intrinsic membrane properties and dopamine shape spiking activity in a motor axon. J Neurosci. 2009;29:5062-74 pubmed publisher
Bal R, Baydas G. Electrophysiological properties of octopus neurons of the cat cochlear nucleus: an in vitro study. J Assoc Res Otolaryngol. 2009;10:281-93 pubmed publisher
Russo M, Yau H, Nunzi M, Mugnaini E, Martina M. Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells. J Neurophysiol. 2008;100:3351-60 pubmed publisher
Safiulina V, Zacchi P, Taglialatela M, Yaari Y, Cherubini E. Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus. J Physiol. 2008;586:5437-53 pubmed publisher
Molineux M, Mehaffey W, Tadayonnejad R, Anderson D, Tennent A, Turner R. Ionic factors governing rebound burst phenotype in rat deep cerebellar neurons. J Neurophysiol. 2008;100:2684-701 pubmed publisher
Brager D, Johnston D. Plasticity of intrinsic excitability during long-term depression is mediated through mGluR-dependent changes in I(h) in hippocampal CA1 pyramidal neurons. J Neurosci. 2007;27:13926-37 pubmed
Angelo K, London M, Christensen S, Hausser M. Local and global effects of I(h) distribution in dendrites of mammalian neurons. J Neurosci. 2007;27:8643-53 pubmed
Lee C, Tepper J. A calcium-activated nonselective cation conductance underlies the plateau potential in rat substantia nigra GABAergic neurons. J Neurosci. 2007;27:6531-41 pubmed
Lee S, Ishida A. Ih without Kir in adult rat retinal ganglion cells. J Neurophysiol. 2007;97:3790-9 pubmed
Bender R, Kirschstein T, Kretz O, Brewster A, Richichi C, Rüschenschmidt C, et al. Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci. 2007;27:4697-706 pubmed
Narushima M, Uchigashima M, Fukaya M, Matsui M, Manabe T, Hashimoto K, et al. Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum. J Neurosci. 2007;27:496-506 pubmed
Zhong N, Zucker R. cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction. J Neurosci. 2005;25:208-14 pubmed
Adachi T, Robinson D, Miles G, Funk G. Noradrenergic modulation of XII motoneuron inspiratory activity does not involve alpha2-receptor inhibition of the Ih current or presynaptic glutamate release. J Appl Physiol (1985). 2005;98:1297-308 pubmed
Seeburg D, Liu X, Chen C. Frequency-dependent modulation of retinogeniculate transmission by serotonin. J Neurosci. 2004;24:10950-62 pubmed
Chan C, Shigemoto R, Mercer J, Surmeier D. HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons. J Neurosci. 2004;24:9921-32 pubmed
Gill C, Randall A, Bates S, Hill K, Owen D, Larkman P, et al. Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Pharmacol. 2004;143:411-21 pubmed
Doan T, Stephans K, Ramirez A, Glazebrook P, Andresen M, Kunze D. Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers. J Neurosci. 2004;24:3335-43 pubmed
Hegg C, Lucero M. Dopamine reduces odor- and elevated-K(+)-induced calcium responses in mouse olfactory receptor neurons in situ. J Neurophysiol. 2004;91:1492-9 pubmed
product information
master code :
1000
SKU :
1000/10
product name :
ZD 7288
unit size :
10 mg (also 50 mg)
description :
Inhibits pacemaker (If) current
target :
Ion Channel Modulators
category :
Small Molecules
purity :
99%
observed molecular weight :
292.81
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
ZD 7288 is a sino-atrial node function modulator; blocks the hyperpolarization activated cation current If (HCN channel). Blocks Ih in central neurons. Increases NMDA-evoked noradrenaline release in rat brain in vitro .
top caption :
Inhibits pacemaker (If) current
extended description :
Inhibits pacemaker (If) current
chemical name text :
4-Ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride
formula :
C15H21ClN4
formula text :
C15H21ClN4
cas num :
133059-99-1
USD :
219 USD
product details :
Inhibits pacemaker (If) current
alt names :
ICI D7288
storage :
Desiccate at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK