Spiperone hydrochloride | Tocris Bioscience 0995 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Spiperone hydrochloride

catalog :

0995

quantity :

50 mg

price :

127 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Walory J, Mielczarek L, Jarończyk M, Koronkiewicz M, Kossakowski J, Bugno R, et al. Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands. Int J Mol Sci. 2018;19: pubmed publisher
Titlow J, Rufer J, King K, Cooper R. Pharmacological analysis of dopamine modulation in the Drosophila melanogaster larval heart. Physiol Rep. 2013;1:e00020 pubmed publisher
Baca M, Allan A, Partridge L, Wilson M. Gene-environment interactions affect long-term depression (LTD) through changes in dopamine receptor affinity in Snap25 deficient mice. Brain Res. 2013;1532:85-98 pubmed publisher
Nickla D, Totonelly K, Dhillon B. Dopaminergic agonists that result in ocular growth inhibition also elicit transient increases in choroidal thickness in chicks. Exp Eye Res. 2010;91:715-20 pubmed publisher
Zapata A, Kivell B, Han Y, Javitch J, Bolan E, Kuraguntla D, et al. Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. J Biol Chem. 2007;282:35842-54 pubmed
Meredith E, Holder M, Rosén A, Lee A, Dyer M, Barnes N, et al. Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma. Proc Natl Acad Sci U S A. 2006;103:13485-90 pubmed

product information

brand :

Tocris

master code :

0995

SKU :

0995/50

product name :

Spiperone hydrochloride

description :

5-HT2A antagonist; also D2-like antagonist

target :

5-HT2A Receptor Antagonists

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

431.94

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Antipsychotic.

catalog number base :

995

product keywords :

D2-like antagonists 5-HT2A Dopamine Non-Selective Receptors Serotonin dopaminergic 5-HT2A Receptors Non-selective Dopamine 0995,

extended description :

5-HT2A antagonist; also D2-like antagonist

chemical name text :

8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride

formula :

C 23 H 26 FN 3 O 2 .HCl

formula text :

C23H26FN3O2.HCl

cas num :

2022-29-9

2020 USD :

123

2021 USD :

127 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage