0991/10 | Tocris Bioscience 0991/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0991/10

catalog :

0991/10

quantity :

10 mg (also 50 mg)

price :

222 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Ratner C, Ettrup A, Bueter M, Haahr M, Compan V, le Roux C, et al. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass. Obesity (Silver Spring). 2012;20:2133-41 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Müller T, Dürk T, Blumenthal B, Grimm M, Cicko S, Panther E, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS ONE. 2009;4:e6453 pubmed publisher
Huang Y, Kandel E. Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis. Learn Mem. 2007;14:497-503 pubmed

product information

master code :

991

SKU :

0991/10

product name :

RS 39604 hydrochloride

unit size :

10 mg (also 50 mg)

description :

5-HT4 antagonist

target :

5-HT4 Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

590.56

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RS 39604 hydrochloride is a potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and 1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.

top caption :

5-HT4 antagonist

extended description :

5-HT4 antagonist

chemical name text :

1-[4-Amino-5-chloro-2-(3,5-dimethoxyphenyl)methyloxy]-3-[1-[2-methylsulphonylamino]ethyl]piperidin-4-yl]propan-1-one hydrochloride

formula :

C26H36ClN3O6S.HCl

formula text :

C26H36ClN3O6S.HCl

cas num :

167710-87-4

USD :

222 USD

product details :

5-HT4 antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage