RS 67333 hydrochloride | Tocris Bioscience 0989 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RS 67333 hydrochloride

catalog :

0989

quantity :

10 mg (also 50 mg)

price :

160 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Eriksson T, Alvarsson A, Stan T, Zhang X, Hascup K, Hascup E, et al. Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Mol Psychiatry. 2013;18:1096-105 pubmed publisher
Müller T, Dürk T, Blumenthal B, Grimm M, Cicko S, Panther E, et al. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS ONE. 2009;4:e6453 pubmed publisher
Warner Schmidt J, Flajolet M, Maller A, Chen E, Qi H, Svenningsson P, et al. Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. J Neurosci. 2009;29:1937-46 pubmed publisher
Huang Y, Kandel E. Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis. Learn Mem. 2007;14:497-503 pubmed
Huang Y, Kandel E. 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. J Neurosci. 2007;27:3111-9 pubmed

product information

brand :

Tocris

master code :

0989

SKU :

0989/10

product name :

RS 67333 hydrochloride

description :

5-HT4 partial agonist

target :

5-HT4 Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

389.36

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A potent and highly selective 5-HT4 partial agonist, with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. Active in vivo , with an intrinsic activity relative to 5-HT of 0.5.

catalog number base :

989

product keywords :

5-HT4 partial agonists Serotonin Receptors 5-Hydroxytryptamine RS67333 hydrochloride 5-HT4 Receptors 0989,

extended description :

5-HT4 partial agonist

chemical name text :

1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride

formula :

C 19 H 29 ClN 2 O 2 .HCl

formula text :

C19H29ClN2O2.HCl

cas num :

168986-60-5

2020 USD :

155

2021 USD :

160 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage