product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0984/10
catalog :
0984/10
quantity :
10 mg (also 50 mg)
price :
259 USD
more info or order :
citations: 10
Reference
Kreye J, Wenke N, Chayka M, Leubner J, Murugan R, Maier N, et al. Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis. Brain. 2016;139:2641-2652 pubmed
Yu J, Swietek B, Proddutur A, Santhakumar V. Dentate cannabinoid-sensitive interneurons undergo unique and selective strengthening of mutual synaptic inhibition in experimental epilepsy. Neurobiol Dis. 2016;89:23-35 pubmed publisher
Ding Z, Ingraham C, Rodd Z, McBride W. The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors. J Psychopharmacol. 2015;29:725-33 pubmed publisher
Jaiswal M, Keros S, Zhao M, Inan M, Schwartz T, Anderson S, et al. Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunit. Front Cell Neurosci. 2015;9:127 pubmed publisher
Stewart A, Maity B, Wunsch A, Meng F, Wu Q, Wemmie J, et al. Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. FASEB J. 2014;28:1735-44 pubmed publisher
Fritsch B, Qashu F, Figueiredo T, Aroniadou Anderjaska V, Rogawski M, Braga M. Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis. Neuroscience. 2009;163:415-29 pubmed publisher
Kitagawa Y, Hirano T, Kawaguchi S. Prediction and validation of a mechanism to control the threshold for inhibitory synaptic plasticity. Mol Syst Biol. 2009;5:280 pubmed publisher
Gryder D, Castaneda D, Rogawski M. Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala. J Neurochem. 2005;94:1728-38 pubmed
Margeta Mitrovic M, Jan Y, Jan L. Ligand-induced signal transduction within heterodimeric GABA(B) receptor. Proc Natl Acad Sci U S A. 2001;98:14643-8 pubmed
Wood M, Murkitt K, Rice S, Testa T, Punia P, Stammers M, et al. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000;131:1050-4 pubmed
product information
master code :
984
SKU :
0984/10
product name :
SCH 50911
unit size :
10 mg (also 50 mg)
description :
Selective and competitive GABAB antagonist; orally bioavailable
target :
GABA-B Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
173.21
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SCH 50911 is a selective, competitive and orally active GABAB antagonist. Displays an IC50 of 1.1 u M at GABAB, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABAA at concentrations up to 100 u M.
top caption :
Selective and competitive GABAB antagonist; orally bioavailable
extended description :
Selective and competitive GABAB antagonist; orally bioavailable
chemical name text :
(2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid
formula :
C8H15NO3
formula text :
C8H15NO3
cas num :
733717-87-8
USD :
259 USD
product details :
Selective and competitive GABAB antagonist; orally bioavailable
storage :
Desiccate at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK