product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0984/10
catalog :
0984/10
quantity :
10 mg (also 50 mg)
price :
259 USD
more info or order :
citations: 10
Reference |
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Kreye J, Wenke N, Chayka M, Leubner J, Murugan R, Maier N, et al. Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis. Brain. 2016;139:2641-2652 pubmed
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Gryder D, Castaneda D, Rogawski M. Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala. J Neurochem. 2005;94:1728-38 pubmed
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Margeta Mitrovic M, Jan Y, Jan L. Ligand-induced signal transduction within heterodimeric GABA(B) receptor. Proc Natl Acad Sci U S A. 2001;98:14643-8 pubmed
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Wood M, Murkitt K, Rice S, Testa T, Punia P, Stammers M, et al. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. Br J Pharmacol. 2000;131:1050-4 pubmed
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product information
master code :
984
SKU :
0984/10
product name :
SCH 50911
unit size :
10 mg (also 50 mg)
description :
Selective and competitive GABAB antagonist; orally bioavailable
target :
GABA-B Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
173.21
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SCH 50911 is a selective, competitive and orally active GABAB antagonist. Displays an IC50 of 1.1 u M at GABAB, approximately 60 times that of CGP 35348 (Cat. No. 1245) and no binding affinity for GABAA at concentrations up to 100 u M.
top caption :
Selective and competitive GABAB antagonist; orally bioavailable
extended description :
Selective and competitive GABAB antagonist; orally bioavailable
chemical name text :
(2S)-(+)-5,5-Dimethyl-2-morpholineacetic acid
formula :
C8H15NO3
formula text :
C8H15NO3
cas num :
733717-87-8
USD :
259 USD
product details :
Selective and competitive GABAB antagonist; orally bioavailable
storage :
Desiccate at -20░C
more info or order :
company information

Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
headquarters: UK
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