0972/5 | Tocris Bioscience 0972/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0972/5

catalog :

0972/5

quantity :

5 mg (also 25 mg)

price :

131 USD

more info or order :

Tocris Bioscience product webpage

citations: 21

Reference
Hellmer C, Clemons M, Nawy S, Ichinose T. A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina. Physiol Rep. 2018;6:e13885 pubmed publisher
Dornier E, Rabas N, Mitchell L, Novo D, Dhayade S, Marco S, et al. Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nat Commun. 2017;8:2255 pubmed publisher
Tassin V, Girard B, Chotte A, Fontanaud P, Rigault D, Kalinichev M, et al. Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network. Front Neural Circuits. 2016;10:31 pubmed publisher
Spampinato S, Merlo S, Chisari M, Nicoletti F, Sortino M. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes. Front Cell Neurosci. 2014;8:462 pubmed publisher
Nieus T, Mapelli L, D Angelo E. Regulation of output spike patterns by phasic inhibition in cerebellar granule cells. Front Cell Neurosci. 2014;8:246 pubmed publisher
Bennett L, Hopiavuori B, Brush R, Chan M, Van Hook M, Thoreson W, et al. Examination of VLC-PUFA-deficient photoreceptor terminals. Invest Ophthalmol Vis Sci. 2014;55:4063-72 pubmed publisher
Domin H, Gołembiowska K, Jantas D, Kaminska K, Zieba B, Śmiałowska M. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Neurotox Res. 2014;26:99-113 pubmed publisher
De May C, Ali A. Cell type-specific regulation of inhibition via cannabinoid type 1 receptors in rat neocortex. J Neurophysiol. 2013;109:216-24 pubmed publisher
Cassé F, Bardou I, Danglot L, Briens A, Montagne A, Parcq J, et al. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci. 2012;32:5186-99 pubmed publisher
Ichinose T, Lukasiewicz P. The mode of retinal presynaptic inhibition switches with light intensity. J Neurosci. 2012;32:4360-71 pubmed publisher
He S, Shao L, Rittase W, Bausch S. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR. Neuropsychopharmacology. 2012;37:1338-56 pubmed publisher
Broadstock M, Austin P, Betts M, Duty S. Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata. Br J Pharmacol. 2012;165:1034-45 pubmed publisher
Ali A. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1. J Neurophysiol. 2011;105:1051-62 pubmed publisher
Zhang J, Jeffrey B, Morgans C, Burke N, Haley T, Duvoisin R, et al. RGS7 and -11 complexes accelerate the ON-bipolar cell light response. Invest Ophthalmol Vis Sci. 2010;51:1121-9 pubmed publisher
Balakrishnan V, Kuo S, Roberts P, Trussell L. Slow glycinergic transmission mediated by transmitter pooling. Nat Neurosci. 2009;12:286-94 pubmed publisher
Rancillac A, Rossier J, Guille M, Tong X, Geoffroy H, Amatore C, et al. Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. J Neurosci. 2006;26:6997-7006 pubmed
Jiang Q, Yan Z, Feng J. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J Neurosci. 2006;26:4318-28 pubmed
Newman E. Calcium increases in retinal glial cells evoked by light-induced neuronal activity. J Neurosci. 2005;25:5502-10 pubmed
Mathiesen J, Svendsen N, Brauner Osborne H, Thomsen C, Ramirez M. Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol. 2003;138:1026-30 pubmed
Nishi A, Liu F, Matsuyama S, Hamada M, Higashi H, Nairn A, et al. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling. Proc Natl Acad Sci U S A. 2003;100:1322-7 pubmed
Collard C, Park K, Montalto M, Alapati S, Buras J, Stahl G, et al. Neutrophil-derived glutamate regulates vascular endothelial barrier function. J Biol Chem. 2002;277:14801-11 pubmed

product information

master code :

972

SKU :

0972/5

product name :

CPPG

unit size :

5 mg (also 25 mg)

description :

Potent group III mGlu antagonist

target :

Group III mGluR Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

271.21

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CPPG is a potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). A much less potent antagonist at group I receptors in neonatal rat cortical slices (KB = 0.65 0.07 nM).

top caption :

Potent group III mGlu antagonist

extended description :

Potent group III mGlu antagonist

chemical name text :

(RS)- -Cyclopropyl-4-phosphonophenylglycine

formula :

C11H14NO5P

formula text :

C11H14NO5P

cas num :

183364-82-1

USD :

131 USD

product details :

Potent group III mGlu antagonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage