0970/100 | Tocris Bioscience 0970/100 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

0970/100

catalog :

0970/100

quantity :

100 mg

price :

108 USD

more info or order :

Tocris Bioscience product webpage

citations: 20

Reference
Paige C, Mejia G, Dussor G, PRICE T. AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo. Neurobiol Pain. 2019;5: pubmed publisher
Zhang X, Zhao Y, Wang C, Ju H, Liu W, Zhang X, et al. Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels. Cell Commun Signal. 2018;16:65 pubmed publisher
Paul S, Dansithong W, Figueroa K, Scoles D, Pulst S. Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration. Nat Commun. 2018;9:3648 pubmed publisher
Shin W, Lee S, Hwang J, Park J, Cho Y, Ro E, et al. Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling. Exp Mol Med. 2018;50:71 pubmed publisher
Yang S, Liu L, Cao C, Song N, Wang Y, Ma S, et al. USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization. Nat Commun. 2018;9:1285 pubmed publisher
Wu N, Tasker J. Nongenomic Glucocorticoid Suppression of a Postsynaptic Potassium Current via Emergent Autocrine Endocannabinoid Signaling in Hypothalamic Neuroendocrine Cells following Chronic Dehydration. Eneuro. 2017;4: pubmed publisher
Di S, Itoga C, Fisher M, Solomonow J, Roltsch E, Gilpin N, et al. Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala. J Neurosci. 2016;36:8461-70 pubmed publisher
Wiedermann G, Bone R, Silva J, Björklund M, Murray P, Dale J. A balance of positive and negative regulators determines the pace of the segmentation clock. elife. 2015;4:e05842 pubmed publisher
Briz V, Zhu G, Wang Y, Liu Y, Avetisyan M, Bi X, et al. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. J Neurosci. 2015;35:2269-82 pubmed publisher
Bhatnagar S, Soni M, Wrighton L, Hebert A, Zhou A, Paul P, et al. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. J Biol Chem. 2014;289:25276-86 pubmed publisher
Gupta A, Gomes I, Wardman J, Devi L. Opioid receptor function is regulated by post-endocytic peptide processing. J Biol Chem. 2014;289:19613-26 pubmed publisher
Wang Y, Zhu G, Briz V, Hsu Y, Bi X, Baudry M. A molecular brake controls the magnitude of long-term potentiation. Nat Commun. 2014;5:3051 pubmed publisher
Ramiro Cortés Y, Israely I. Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression. PLoS ONE. 2013;8:e71155 pubmed publisher
Bernard P, Castano A, O Leary H, Simpson K, Browning M, Benke T. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Neurobiol Dis. 2013;59:1-17 pubmed publisher
Pont J, McArdle C, Lopez Bernal A. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol Endocrinol. 2012;26:1743-56 pubmed
Zhao W, Chuang S, Bianchi R, Wong R. Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus. J Neurosci. 2011;31:725-34 pubmed publisher
Huang Y, Yang C, Huang C, Tai M, Hsu K. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor. J Neurosci. 2010;30:6080-93 pubmed publisher
Argadine H, Hellyer N, Mantilla C, Zhan W, Sieck G. The effect of denervation on protein synthesis and degradation in adult rat diaphragm muscle. J Appl Physiol (1985). 2009;107:438-44 pubmed publisher
Wong S, Leung F, Lau C, Au C, Yung L, Yao X, et al. Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res. 2009;104:228-35 pubmed publisher
Chan J, Cheng H, Chou J, Li F, Dai K, Chan S, et al. Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death. J Biol Chem. 2007;282:4585-600 pubmed

product information

master code :

970

SKU :

0970/100

product name :

Cycloheximide

unit size :

100 mg

description :

Inhibitor of protein synthesis

target :

DNA, RNA and Protein Synthesis Inhibitors

category :

Small Molecules

purity :

97%

observed molecular weight :

281.35

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cycloheximide is a selective inhibitor of eukaryotic (over prokaryotic) protein synthesis, blocking tRNA binding and release from ribosomes. Induces apoptosis in a variety of transformed and normal cell lines, including T cells. Competitively inhibits the PPIase hFKBP12 (Ki = 3.4 M). Also inhibits ferroptosis. Antifungal antibiotic. Exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.16 M).

top caption :

Inhibitor of protein synthesis

extended description :

Inhibitor of protein synthesis

chemical name text :

4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione

formula :

C15H23NO4

formula text :

C15H23NO4

cas num :

66-81-9

USD :

108 USD

product details :

Inhibitor of protein synthesis

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage