product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Xamoterol hemifumarate
catalog :
0950
quantity :
10 mg (also 50 mg)
price :
182 USD
more info or order :
citations: 9
Reference
Zhi X, Li B, Li Z, Zhang J, Yu J, Zhang L, et al. Adrenergic modulation of AMPK‑dependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer. Int J Oncol. 2019;54:1625-1638 pubmed publisher
Picard L, Schönegge A, Lohse M, Bouvier M. Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Commun Biol. 2018;1:106 pubmed publisher
Lavine J, Farnoodian M, Wang S, Darjatmoko S, Wright L, Gamm D, et al. ?2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci. 2017;58:299-308 pubmed publisher
Creed S, Le C, Hassan M, Pon C, Albold S, Chan K, et al. β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion. Breast Cancer Res. 2015;17:145 pubmed publisher
Copik A, Baldys A, Nguyen K, Sahdeo S, Ho H, Kosaka A, et al. Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. PLoS ONE. 2015;10:e0115701 pubmed publisher
Lavine J, Sang Y, Wang S, Ip M, Sheibani N. Attenuation of choroidal neovascularization by ?(2)-adrenoreceptor antagonism. JAMA Ophthalmol. 2013;131:376-82 pubmed publisher
Rankovic V, Landgraf P, Kanyshkova T, Ehling P, Meuth S, Kreutz M, et al. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via ?-adrenergic signaling in thalamocortical relay neurons. PLoS ONE. 2011;6:e27474 pubmed publisher
Baker J, Kemp P, March J, Fretwell L, Hill S, Gardiner S. Predicting in vivo cardiovascular properties of ?-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J. 2011;25:4486-97 pubmed publisher
Steinle J, Booz G, Meininger C, Day J, Granger H. Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation. J Biol Chem. 2003;278:20681-6 pubmed
product information
brand :
Tocris
master code :
0950
SKU :
0950/10
product name :
Xamoterol hemifumarate
description :
Selective 1 partial agonist
target :
Adrenergic beta-1 Receptor Agonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
97%
observed molecular weight :
397.43
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
1-adrenoceptor-selective partial agonist (pA2 values are 7.4 - 7.8 and 5.2 - 6.2 at 1- and 2-adrenoceptors respectively).
catalog number base :
950
product keywords :
1-adrenoceptors 1-adrenoceptor beta1-adrenoceptors 1-Adrenergic beta1-Adrenergic b1-adrenergic b1-adrenoceptors selective partial agonists Receptors ICI118587 AstraZeneca ICI 118,587 Adrenergic Beta-1 Receptors 0950,
extended description :
Selective 1 partial agonist
chemical name text :
1-(4-Hydroxyphenoxy)-3-[2-(4-morpholinocarboxamido)ethylamino]-2-propanol hemifumarate
formula :
C 16 H 25 N 3 O 5 .0.5C 4 H 4 O 4
formula text :
C16H25N3O5.0.5C4H4O4
cas num :
73210-73-8
2020 USD :
176
2021 USD :
182 USD
alt names :
ICI 118,587
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK