product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
0950/10
catalog :
0950/10
quantity :
10 mg (also 50 mg)
price :
230 USD
more info or order :
citations: 11
Reference
Zhi X, Li B, Li Z, Zhang J, Yu J, Zhang L, et al. Adrenergic modulation of AMPK‑dependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer. Int J Oncol. 2019;54:1625-1638 pubmed publisher
Picard L, Schönegge A, Lohse M, Bouvier M. Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes. Commun Biol. 2018;1:106 pubmed publisher
Lavine J, Farnoodian M, Wang S, Darjatmoko S, Wright L, Gamm D, et al. ?2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci. 2017;58:299-308 pubmed publisher
Creed S, Le C, Hassan M, Pon C, Albold S, Chan K, et al. β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion. Breast Cancer Res. 2015;17:145 pubmed publisher
Copik A, Baldys A, Nguyen K, Sahdeo S, Ho H, Kosaka A, et al. Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. PLoS ONE. 2015;10:e0115701 pubmed publisher
Li X, Nooh M, Bahouth S. Role of AKAP79/150 protein in ?1-adrenergic receptor trafficking and signaling in mammalian cells. J Biol Chem. 2013;288:33797-812 pubmed publisher
Lavine J, Sang Y, Wang S, Ip M, Sheibani N. Attenuation of choroidal neovascularization by ?(2)-adrenoreceptor antagonism. JAMA Ophthalmol. 2013;131:376-82 pubmed publisher
Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
Rankovic V, Landgraf P, Kanyshkova T, Ehling P, Meuth S, Kreutz M, et al. Modulation of calcium-dependent inactivation of L-type Ca2+ channels via ?-adrenergic signaling in thalamocortical relay neurons. PLoS ONE. 2011;6:e27474 pubmed publisher
Baker J, Kemp P, March J, Fretwell L, Hill S, Gardiner S. Predicting in vivo cardiovascular properties of ?-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J. 2011;25:4486-97 pubmed publisher
Steinle J, Booz G, Meininger C, Day J, Granger H. Beta 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation. J Biol Chem. 2003;278:20681-6 pubmed
product information
master code :
950
SKU :
0950/10
product name :
Xamoterol hemifumarate
unit size :
10 mg (also 50 mg)
description :
Selective 1 partial agonist
target :
Adrenergic beta-1 Receptor Agonists
category :
Small Molecules
purity :
97%
observed molecular weight :
397.43
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Xamoterol hemifumarate is a 1-adrenoceptor-selective partial agonist (pA2 values are 7.4 - 7.8 and 5.2 - 6.2 at 1- and 2-adrenoceptors respectively).
top caption :
Selective 1 partial agonist
extended description :
Selective 1 partial agonist
chemical name text :
1-(4-Hydroxyphenoxy)-3-[2-(4-morpholinocarboxamido)ethylamino]-2-propanol hemifumarate
formula :
C16H25N3O5.0.5C4H4O4
formula text :
C16H25N3O5.0.5C4H4O4
cas num :
73210-73-8
USD :
230 USD
product details :
Selective 1 partial agonist
alt names :
ICI 118,587
storage :
Store at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK